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Anti-DNA antibodies in systemic lupus erythematosus.

Publication ,  Journal Article
Pisetsky, DS
Published in: Rheum Dis Clin North Am
May 1992

Anti-DNA antibodies are the serologic hallmark of systemic lupus erythematosus and important markers for diagnosis and prognosis. Although a number of mechanisms for anti-DNA production have been proposed, recent evidence from human as well as murine lupus indicate a prominent role of DNA antigen drive. To identify further the basis of this response, current research is focusing on the structural features of DNA associated with immunogenicity in both the normal and autoimmune settings. Elucidating these mechanisms should thus provide insights into the pathogenesis of systemic lupus erythematosus as well as the immunologic activity of nucleic acids.

Duke Scholars

Published In

Rheum Dis Clin North Am

ISSN

0889-857X

Publication Date

May 1992

Volume

18

Issue

2

Start / End Page

437 / 454

Location

United States

Related Subject Headings

  • Reference Values
  • Lupus Erythematosus, Systemic
  • Immunoglobulin Idiotypes
  • Immunity
  • Humans
  • DNA
  • Arthritis & Rheumatology
  • Antigens
  • Antibody Formation
  • Antibodies, Antinuclear
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Pisetsky, D. S. (1992). Anti-DNA antibodies in systemic lupus erythematosus. Rheum Dis Clin North Am, 18(2), 437–454.
Pisetsky, D. S. “Anti-DNA antibodies in systemic lupus erythematosus.Rheum Dis Clin North Am 18, no. 2 (May 1992): 437–54.
Pisetsky DS. Anti-DNA antibodies in systemic lupus erythematosus. Rheum Dis Clin North Am. 1992 May;18(2):437–54.
Pisetsky, D. S. “Anti-DNA antibodies in systemic lupus erythematosus.Rheum Dis Clin North Am, vol. 18, no. 2, May 1992, pp. 437–54.
Pisetsky DS. Anti-DNA antibodies in systemic lupus erythematosus. Rheum Dis Clin North Am. 1992 May;18(2):437–454.
Journal cover image

Published In

Rheum Dis Clin North Am

ISSN

0889-857X

Publication Date

May 1992

Volume

18

Issue

2

Start / End Page

437 / 454

Location

United States

Related Subject Headings

  • Reference Values
  • Lupus Erythematosus, Systemic
  • Immunoglobulin Idiotypes
  • Immunity
  • Humans
  • DNA
  • Arthritis & Rheumatology
  • Antigens
  • Antibody Formation
  • Antibodies, Antinuclear