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DNA as a marker of cell death in systemic lupus erythematosus.
Publication
, Journal Article
Pisetsky, DS
Published in: Rheum Dis Clin North Am
August 2004
DNA circulates in the blood in systemic lupus erythematosus, among other conditions, and plays a role in immunopathogenesis in the form of immune complexes. As shown in experiments in mice, blood DNA levels rise following treatments to induce apoptosis and the administration of cells made apoptotic or necrotic in vitro. In mice lacking macrophage function, however, blood levels do not rise following administration of dead cells. These results indicate that circulating DNA may be a marker of cell death, although its levels likely reflect a complex process involving the interactions of macrophages with dead and dying cells.
Duke Scholars
Published In
Rheum Dis Clin North Am
DOI
ISSN
0889-857X
Publication Date
August 2004
Volume
30
Issue
3
Start / End Page
575 / x
Location
United States
Related Subject Headings
- Lupus Erythematosus, Systemic
- Humans
- Disease Models, Animal
- DNA
- Biomarkers
- Arthritis & Rheumatology
- Apoptosis
- Antibodies, Antinuclear
- Animals
- 3202 Clinical sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Pisetsky, D. S. (2004). DNA as a marker of cell death in systemic lupus erythematosus. Rheum Dis Clin North Am, 30(3), 575–x. https://doi.org/10.1016/j.rdc.2004.04.009
Pisetsky, David S. “DNA as a marker of cell death in systemic lupus erythematosus.” Rheum Dis Clin North Am 30, no. 3 (August 2004): 575–x. https://doi.org/10.1016/j.rdc.2004.04.009.
Pisetsky DS. DNA as a marker of cell death in systemic lupus erythematosus. Rheum Dis Clin North Am. 2004 Aug;30(3):575–x.
Pisetsky, David S. “DNA as a marker of cell death in systemic lupus erythematosus.” Rheum Dis Clin North Am, vol. 30, no. 3, Aug. 2004, pp. 575–x. Pubmed, doi:10.1016/j.rdc.2004.04.009.
Pisetsky DS. DNA as a marker of cell death in systemic lupus erythematosus. Rheum Dis Clin North Am. 2004 Aug;30(3):575–x.
![Journal cover image](https://secure.syndetics.com/index.aspx?isbn=/lc.gif&issn=0889-857X&client=dukeuniv)
Published In
Rheum Dis Clin North Am
DOI
ISSN
0889-857X
Publication Date
August 2004
Volume
30
Issue
3
Start / End Page
575 / x
Location
United States
Related Subject Headings
- Lupus Erythematosus, Systemic
- Humans
- Disease Models, Animal
- DNA
- Biomarkers
- Arthritis & Rheumatology
- Apoptosis
- Antibodies, Antinuclear
- Animals
- 3202 Clinical sciences