Immune responses to DNA in normal and aberrant immunity.
Publication
, Journal Article
Pisetsky, DS
Published in: Immunol Res
2000
Because of structural microheterogeneity, DNA can exert powerful effects that lead to immune system activation as well as antibody induction. These activating effects resemble those ofendotoxin and result from sequences that occur much more commonly in bacterial DNA than in mammalian DNA. In contrast, mammalian DNA can inhibit the response to bacterial DNA as well as other stimuli and may serve a counterregulatory role during infection. The recognition of the immune effects of DNA is relevant to the pathogenesis of a variety of infectious and inflammatory diseases including systemic lupus erythematosus, a prototypic autoimmune disease characterized by anti-DNA autoantibodies.
Duke Scholars
Published In
Immunol Res
DOI
ISSN
0257-277X
Publication Date
2000
Volume
22
Issue
2-3
Start / End Page
119 / 126
Location
United States
Related Subject Headings
- Lupus Erythematosus, Systemic
- Interleukin-12
- Immunology
- Immune System
- Humans
- DNA, Bacterial
- DNA
- Antibodies, Bacterial
- Antibodies, Antinuclear
- Animals
Citation
APA
Chicago
ICMJE
MLA
NLM
Pisetsky, D. S. (2000). Immune responses to DNA in normal and aberrant immunity. Immunol Res, 22(2–3), 119–126. https://doi.org/10.1385/IR:22:2-3:119
Pisetsky, D. S. “Immune responses to DNA in normal and aberrant immunity.” Immunol Res 22, no. 2–3 (2000): 119–26. https://doi.org/10.1385/IR:22:2-3:119.
Pisetsky DS. Immune responses to DNA in normal and aberrant immunity. Immunol Res. 2000;22(2–3):119–26.
Pisetsky, D. S. “Immune responses to DNA in normal and aberrant immunity.” Immunol Res, vol. 22, no. 2–3, 2000, pp. 119–26. Pubmed, doi:10.1385/IR:22:2-3:119.
Pisetsky DS. Immune responses to DNA in normal and aberrant immunity. Immunol Res. 2000;22(2–3):119–126.
Published In
Immunol Res
DOI
ISSN
0257-277X
Publication Date
2000
Volume
22
Issue
2-3
Start / End Page
119 / 126
Location
United States
Related Subject Headings
- Lupus Erythematosus, Systemic
- Interleukin-12
- Immunology
- Immune System
- Humans
- DNA, Bacterial
- DNA
- Antibodies, Bacterial
- Antibodies, Antinuclear
- Animals