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Developments in the scientific understanding of lupus.

Publication ,  Journal Article
Ardoin, SP; Pisetsky, DS
Published in: Arthritis Res Ther
2008

Systemic lupus erythematosus is a systemic autoimmune disease characterized by the production of antinuclear antibodies (ANAs). Recent research into human and murine lupus suggests that disease susceptibility results from genetic polymorphisms regulating immune responses as well as impairing the clearance of apoptotic cells. Because the products of dead cells, including nucleic acids, have immunologic activity, this situation can promote antigen-driven ANA responses. Furthermore, immune complexes of ANAs can drive the production of proinflammatory cytokines, inducing the 'interferon signature', and intensifying disease. Together, these findings point to new genetic and immunologic markers of disease as well as targets for new therapies.

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Published In

Arthritis Res Ther

DOI

EISSN

1478-6362

Publication Date

2008

Volume

10

Issue

5

Start / End Page

218

Location

England

Related Subject Headings

  • Lupus Erythematosus, Systemic
  • Humans
  • Genetic Predisposition to Disease
  • Autoantigens
  • Autoantibodies
  • Arthritis & Rheumatology
  • Animals
  • 3204 Immunology
  • 3202 Clinical sciences
  • 1117 Public Health and Health Services
 

Citation

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Ardoin, S. P., & Pisetsky, D. S. (2008). Developments in the scientific understanding of lupus. Arthritis Res Ther, 10(5), 218. https://doi.org/10.1186/ar2488
Ardoin, Stacy P., and David S. Pisetsky. “Developments in the scientific understanding of lupus.Arthritis Res Ther 10, no. 5 (2008): 218. https://doi.org/10.1186/ar2488.
Ardoin SP, Pisetsky DS. Developments in the scientific understanding of lupus. Arthritis Res Ther. 2008;10(5):218.
Ardoin, Stacy P., and David S. Pisetsky. “Developments in the scientific understanding of lupus.Arthritis Res Ther, vol. 10, no. 5, 2008, p. 218. Pubmed, doi:10.1186/ar2488.
Ardoin SP, Pisetsky DS. Developments in the scientific understanding of lupus. Arthritis Res Ther. 2008;10(5):218.

Published In

Arthritis Res Ther

DOI

EISSN

1478-6362

Publication Date

2008

Volume

10

Issue

5

Start / End Page

218

Location

England

Related Subject Headings

  • Lupus Erythematosus, Systemic
  • Humans
  • Genetic Predisposition to Disease
  • Autoantigens
  • Autoantibodies
  • Arthritis & Rheumatology
  • Animals
  • 3204 Immunology
  • 3202 Clinical sciences
  • 1117 Public Health and Health Services