Hyper-Ia antigen expression on B cells from B6-lpr/lpr mice correlates with manifestations of the autoimmune state.
Publication
, Journal Article
Monroe, JG; Cambier, JC; Mody, EA; Pisetsky, DS
Published in: Clin Immunol Immunopathol
January 1985
To investigate the state of activation of B cells from mice with the lpr gene defect, membrane Ia antigen (mIa) expression was analyzed on B cells from B6-lpr/lpr (lpr) and control B6- +/-/+/- mice. B cells from lpr mice exhibited marked increases in levels of mIa as determined by flow cytometry using a monoclonal anti-I-Ab,d reagent. This increase, which was progressive with age, suggests that phenotypic alteration of B-cell mIa expression is a consequence of lpr gene action. Since B-cell activation manifest by elevated mIa expression may promote productive interactions with helper T cells, these observations suggest an important role for B-cell abnormalities in the etiology of lpr-induced autoimmune disease.
Duke Scholars
Published In
Clin Immunol Immunopathol
DOI
ISSN
0090-1229
Publication Date
January 1985
Volume
34
Issue
1
Start / End Page
124 / 129
Location
United States
Related Subject Headings
- Phenotype
- Mice, Mutant Strains
- Mice
- Immunology
- Histocompatibility Antigens Class II
- Female
- B-Lymphocytes
- Autoantibodies
- Animals
Citation
APA
Chicago
ICMJE
MLA
NLM
Monroe, J. G., Cambier, J. C., Mody, E. A., & Pisetsky, D. S. (1985). Hyper-Ia antigen expression on B cells from B6-lpr/lpr mice correlates with manifestations of the autoimmune state. Clin Immunol Immunopathol, 34(1), 124–129. https://doi.org/10.1016/0090-1229(85)90015-7
Monroe, J. G., J. C. Cambier, E. A. Mody, and D. S. Pisetsky. “Hyper-Ia antigen expression on B cells from B6-lpr/lpr mice correlates with manifestations of the autoimmune state.” Clin Immunol Immunopathol 34, no. 1 (January 1985): 124–29. https://doi.org/10.1016/0090-1229(85)90015-7.
Monroe JG, Cambier JC, Mody EA, Pisetsky DS. Hyper-Ia antigen expression on B cells from B6-lpr/lpr mice correlates with manifestations of the autoimmune state. Clin Immunol Immunopathol. 1985 Jan;34(1):124–9.
Monroe, J. G., et al. “Hyper-Ia antigen expression on B cells from B6-lpr/lpr mice correlates with manifestations of the autoimmune state.” Clin Immunol Immunopathol, vol. 34, no. 1, Jan. 1985, pp. 124–29. Pubmed, doi:10.1016/0090-1229(85)90015-7.
Monroe JG, Cambier JC, Mody EA, Pisetsky DS. Hyper-Ia antigen expression on B cells from B6-lpr/lpr mice correlates with manifestations of the autoimmune state. Clin Immunol Immunopathol. 1985 Jan;34(1):124–129.
Published In
Clin Immunol Immunopathol
DOI
ISSN
0090-1229
Publication Date
January 1985
Volume
34
Issue
1
Start / End Page
124 / 129
Location
United States
Related Subject Headings
- Phenotype
- Mice, Mutant Strains
- Mice
- Immunology
- Histocompatibility Antigens Class II
- Female
- B-Lymphocytes
- Autoantibodies
- Animals