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The translocation of HMGB1 during cell activation and cell death.

Publication ,  Journal Article
Gauley, J; Pisetsky, DS
Published in: Autoimmunity
May 2009

High-mobility group box protein 1 (HMGB1) is a non-histone nuclear protein with alarmin activity. When present in an extracellular location, HMGB1 can activate the innate immune system and promote inflammation in conditions such as sepsis. To exert these activities, HMGB1 must transit from the nucleus, through the cytoplasm, to the outside of the cell. This process can occur during cell activation as well as cell death. In murine macrophages (MPhi), stimulation of TLR3 and TLR4, but not TLR9, can cause HMGB1 translocation. With cell death, necrosis can lead to extracellular HMGB1 by a passive mechanism. With apoptosis, HMGB1 is only released during secondary necrosis, when cell permeability barriers break down. Since agents that stimulate MPhi can also induce apoptosis, HMGB1 release following TLR stimulation may also reflect a contribution from dead cells, suggesting a common mechanism for protein release in activation and death.

Duke Scholars

Published In

Autoimmunity

DOI

EISSN

1607-842X

Publication Date

May 2009

Volume

42

Issue

4

Start / End Page

299 / 301

Location

England

Related Subject Headings

  • Protein Transport
  • Macrophage Activation
  • Immunology
  • Humans
  • HMGB1 Protein
  • Apoptosis
  • Animals
  • 3204 Immunology
  • 1107 Immunology
 

Citation

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Chicago
ICMJE
MLA
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Gauley, J., & Pisetsky, D. S. (2009). The translocation of HMGB1 during cell activation and cell death. Autoimmunity, 42(4), 299–301. https://doi.org/10.1080/08916930902831522
Gauley, Julie, and David S. Pisetsky. “The translocation of HMGB1 during cell activation and cell death.Autoimmunity 42, no. 4 (May 2009): 299–301. https://doi.org/10.1080/08916930902831522.
Gauley J, Pisetsky DS. The translocation of HMGB1 during cell activation and cell death. Autoimmunity. 2009 May;42(4):299–301.
Gauley, Julie, and David S. Pisetsky. “The translocation of HMGB1 during cell activation and cell death.Autoimmunity, vol. 42, no. 4, May 2009, pp. 299–301. Pubmed, doi:10.1080/08916930902831522.
Gauley J, Pisetsky DS. The translocation of HMGB1 during cell activation and cell death. Autoimmunity. 2009 May;42(4):299–301.

Published In

Autoimmunity

DOI

EISSN

1607-842X

Publication Date

May 2009

Volume

42

Issue

4

Start / End Page

299 / 301

Location

England

Related Subject Headings

  • Protein Transport
  • Macrophage Activation
  • Immunology
  • Humans
  • HMGB1 Protein
  • Apoptosis
  • Animals
  • 3204 Immunology
  • 1107 Immunology