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Autoantibodies and their idiotypes.

Publication ,  Journal Article
Pisetsky, DS
Published in: Curr Opin Rheumatol
October 1991

Idiotypes are serologically defined markers in the variable region of an antibody molecule. In the study of autoimmunity, these markers have been valuable probes in defining patterns of autoantibody variable region gene utilization, mechanisms of immune dysregulation, and the operation of the network in the generation of abnormal responses. Recent advances in the molecular analysis of immunoglobulin genes have provided insights into the structural basis of autoantibody idiotypes and the manner in which sequence homologies between idiotype-bearing antibodies and autoantigens can lead to autoreactivity. Immune manipulation using these sequences could lead to novel models of disease as well as prospects for immunotherapy.

Duke Scholars

Published In

Curr Opin Rheumatol

DOI

ISSN

1040-8711

Publication Date

October 1991

Volume

3

Issue

5

Start / End Page

731 / 737

Location

United States

Related Subject Headings

  • Lupus Erythematosus, Systemic
  • Immunoglobulin Idiotypes
  • Humans
  • DNA
  • Autoantibodies
  • Arthritis & Rheumatology
  • Antibody Formation
  • Antibodies, Anti-Idiotypic
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Pisetsky, D. S. (1991). Autoantibodies and their idiotypes. Curr Opin Rheumatol, 3(5), 731–737. https://doi.org/10.1097/00002281-199110000-00003
Pisetsky, D. S. “Autoantibodies and their idiotypes.Curr Opin Rheumatol 3, no. 5 (October 1991): 731–37. https://doi.org/10.1097/00002281-199110000-00003.
Pisetsky DS. Autoantibodies and their idiotypes. Curr Opin Rheumatol. 1991 Oct;3(5):731–7.
Pisetsky, D. S. “Autoantibodies and their idiotypes.Curr Opin Rheumatol, vol. 3, no. 5, Oct. 1991, pp. 731–37. Pubmed, doi:10.1097/00002281-199110000-00003.
Pisetsky DS. Autoantibodies and their idiotypes. Curr Opin Rheumatol. 1991 Oct;3(5):731–737.

Published In

Curr Opin Rheumatol

DOI

ISSN

1040-8711

Publication Date

October 1991

Volume

3

Issue

5

Start / End Page

731 / 737

Location

United States

Related Subject Headings

  • Lupus Erythematosus, Systemic
  • Immunoglobulin Idiotypes
  • Humans
  • DNA
  • Autoantibodies
  • Arthritis & Rheumatology
  • Antibody Formation
  • Antibodies, Anti-Idiotypic
  • 3202 Clinical sciences
  • 1103 Clinical Sciences