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Immune response to DNA in systemic lupus erythematosus.

Publication ,  Journal Article
Pisetsky, DS
Published in: Isr Med Assoc J
November 2001

Antibodies to DNA occur prominently in systemic lupus erythematosus and have been extensively studied as probes for underlying immune disturbances. These antibodies have features of DNA antigen drive. While previous models for this response posited DNA as simple and inert, recent studies have indicated that DNA is immunologically diverse and, depending upon sequence and backbone structure, can stimulate or suppress immune responses. In particular, bacterial DNA is immunologically potent and can function as both an adjuvant and immunogen, eliciting in normal individuals antibodies to sites exclusive to bacterial DNA. In mice genetically predisposed to autoimmunity, however, bacterial DNA can elicit anti-DNA autoantibodies under conditions in which mammalian DNA is inactive. These findings suggest that foreign DNA can serve as a trigger for anti-DNA responses, with SLE reflecting a disturbance in antibody specificity and a shift from binding of sequential to backbone determinants. In contrast to bacterial DNA, mammalian DNA can suppress certain immune responses and prevent macrophage cytokine production. To the extent that self-DNA drives responses in SLE, anti-DNA production in this disease may reflect a failure of this suppression. The recognition of DNA's immune activities thus suggests novel possibilities for disease pathogenesis.

Duke Scholars

Published In

Isr Med Assoc J

ISSN

1565-1088

Publication Date

November 2001

Volume

3

Issue

11

Start / End Page

850 / 853

Location

Israel

Related Subject Headings

  • Mice
  • Lupus Erythematosus, Systemic
  • In Vitro Techniques
  • Immune System
  • Humans
  • General & Internal Medicine
  • Antibodies, Antinuclear
  • Animals
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
 

Citation

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ICMJE
MLA
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Pisetsky, D. S. (2001). Immune response to DNA in systemic lupus erythematosus. Isr Med Assoc J, 3(11), 850–853.
Pisetsky, D. S. “Immune response to DNA in systemic lupus erythematosus.Isr Med Assoc J 3, no. 11 (November 2001): 850–53.
Pisetsky DS. Immune response to DNA in systemic lupus erythematosus. Isr Med Assoc J. 2001 Nov;3(11):850–3.
Pisetsky, D. S. “Immune response to DNA in systemic lupus erythematosus.Isr Med Assoc J, vol. 3, no. 11, Nov. 2001, pp. 850–53.
Pisetsky DS. Immune response to DNA in systemic lupus erythematosus. Isr Med Assoc J. 2001 Nov;3(11):850–853.

Published In

Isr Med Assoc J

ISSN

1565-1088

Publication Date

November 2001

Volume

3

Issue

11

Start / End Page

850 / 853

Location

Israel

Related Subject Headings

  • Mice
  • Lupus Erythematosus, Systemic
  • In Vitro Techniques
  • Immune System
  • Humans
  • General & Internal Medicine
  • Antibodies, Antinuclear
  • Animals
  • 42 Health sciences
  • 32 Biomedical and clinical sciences