Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel

Genetics of pseudoexfoliation syndrome.

Publication ,  Journal Article
Challa, P
Published in: Curr Opin Ophthalmol
March 2009

PURPOSE OF REVIEW: Pseudoexfoliation syndrome (XFS) is a late-onset and complex disorder that is strongly associated with the development of glaucoma. The purpose of this review is to discuss the inheritance patterns and recent genetic advances in the study of this disorder. RECENT FINDINGS: XFS has a strong familial association and recently, the lysyl oxidase-like 1 gene has been strongly associated with this disorder. This gene is involved in the synthesis and maintenance of elastic fibers and therefore has a strong biological rationale for being involved in this disorder. However, the exact relationship between lysyl oxidase-like 1 polymorphisms and the development of XFS has not been elucidated. Also, the value of genetic testing for this disorder has not been validated. SUMMARY: XFS is an important risk factor for glaucoma and lysyl oxidase-like 1 polymorphisms are strongly associated with XFS. The mechanisms behind glaucoma development and the value of genetic testing are not clear and further study is needed.

Duke Scholars

Published In

Curr Opin Ophthalmol

DOI

EISSN

1531-7021

Publication Date

March 2009

Volume

20

Issue

2

Start / End Page

88 / 91

Location

United States

Related Subject Headings

  • Polymorphism, Genetic
  • Ophthalmology & Optometry
  • Humans
  • Glaucoma
  • Genetic Predisposition to Disease
  • Exfoliation Syndrome
  • Amino Acid Oxidoreductases
  • 3212 Ophthalmology and optometry
  • 1113 Opthalmology and Optometry
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Challa, P. (2009). Genetics of pseudoexfoliation syndrome. Curr Opin Ophthalmol, 20(2), 88–91. https://doi.org/10.1097/ICU.0b013e328320d86a
Challa, Pratap. “Genetics of pseudoexfoliation syndrome.Curr Opin Ophthalmol 20, no. 2 (March 2009): 88–91. https://doi.org/10.1097/ICU.0b013e328320d86a.
Challa P. Genetics of pseudoexfoliation syndrome. Curr Opin Ophthalmol. 2009 Mar;20(2):88–91.
Challa, Pratap. “Genetics of pseudoexfoliation syndrome.Curr Opin Ophthalmol, vol. 20, no. 2, Mar. 2009, pp. 88–91. Pubmed, doi:10.1097/ICU.0b013e328320d86a.
Challa P. Genetics of pseudoexfoliation syndrome. Curr Opin Ophthalmol. 2009 Mar;20(2):88–91.

Published In

Curr Opin Ophthalmol

DOI

EISSN

1531-7021

Publication Date

March 2009

Volume

20

Issue

2

Start / End Page

88 / 91

Location

United States

Related Subject Headings

  • Polymorphism, Genetic
  • Ophthalmology & Optometry
  • Humans
  • Glaucoma
  • Genetic Predisposition to Disease
  • Exfoliation Syndrome
  • Amino Acid Oxidoreductases
  • 3212 Ophthalmology and optometry
  • 1113 Opthalmology and Optometry