Pratap Challa | Scholars@Duke

Pratap Challa
Professor of Ophthalmology

As a physician-scientist investigator, Dr. Challa has a special research interest in the genetic basis of inherited eye diseases. He has active projects investigating the genetics of Pseudoexfoliation associated glaucoma and the cellular basis for glaucoma development. He also studies ocular drug delivery and is involved in developing long-term delivery devices for glaucoma medications. He also investigates novel compounds that may eventually be used for treating glaucoma. In addition to basic science research, he also has clinical research interests including evaluating the effectiveness of new glaucoma therapies.

Current Appointments & Affiliations

Professor of Ophthalmology, Ophthalmology, Glaucoma, Ophthalmology 2022

Contact Information

Box 3802 Med Ctr, Durham, NC 27710
Wadsworth Bldg, Durham, NC 27710
chall001@mc.duke.edu (919) 681-2793

Background
Education, Training, & Certifications
- M.D., University of Florida 1993
Previous Appointments & Affiliations
- Associate Professor of Ophthalmology, Ophthalmology, Glaucoma, Ophthalmology 2010 - 2022
- Assistant Professor of Ophthalmology, Ophthalmology, Glaucoma, Ophthalmology 2000 - 2010
- Clinical Associate in the Department of Ophthalmology, Ophthalmology, Clinical Science Departments 1998 - 2000
Expertise
Global Scholarship
- Research
  - Ghana (Country)
Research
Selected Grants
- The Swine model of VEGF-induced vascular leakage and interventions thereof awarded by Aerie Pharmaceuticals, Inc. 2022 - 2023
- Animal models of Glaucoma and Eye Disease awarded by Aerie Pharmaceuticals, Inc. 2022 - 2023
- The Role of GDF-15 in Aqueous Humor Outflow and Glaucoma awarded by National Institutes of Health 2018 - 2023
- Trabecular Meshwork Cytoskeletal Signaling-Regulation of Aqueous Humor Outflow awarded by National Institutes of Health 2008 - 2023
- Lysosomal Enzymes in Outflow Pathway Physiology and Pathophysiology awarded by National Institutes of Health 2017 - 2022
- Novel Experimental Model for Pseudoexfolliation Syndrome awarded by National Institutes of Health 2018 - 2020
- Optimization of a Cell Culture Model for Pseudoexfoliation Syndrome awarded by The Glaucoma Foundation 2018 - 2019
- MicroRNA-directed modulation of intraocular pressure awarded by National Institutes of Health 2013 - 2018
- Mechanisms in Exfoliation Glaucoma: Effect of Genetic Risk Variants and Ocular Cell Stressors on LOXL1 Expression awarded by The Glaucoma Foundation 2015 - 2016
- Exosomal RNAs and Aqueous Humor Dynamics in Exfoliation Glaucoma awarded by Glaucoma Research Foundation 2014
- Cellular Senescence and Glaucoma awarded by National Institutes of Health 2011 - 2013
- The Molecular Basis of Pseudoexfoliation Syndrome awarded by National Institutes of Health 2003 - 2009
- Genetic Studies of POAG in Ghana, West Africa awarded by National Institutes of Health 2003 - 2007
- Healthy Vision 2010 Community Awards Program awarded by National Institutes of Health 2004
External Relationships
- Aerie Pharmaceuticals, Inc.
- Durham VA Medical Center
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Aggarwal, Sahil, C Ellis Wisely, Marc J. Pepin, William Bryan, Karthik Raghunathan, and Pratap Challa. “Resident involvement in cataract surgery at the Veterans Health Administration: complications, case complexity, and the role of experience.” J Cataract Refract Surg 49, no. 3 (March 1, 2023): 259–65. https://doi.org/10.1097/j.jcrs.0000000000001092.
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  - Wisely, C Ellis, Sahil Aggarwal, Marc J. Pepin, and Pratap Challa. “COVID-19 pandemic and surgical training: cataract surgery in the Veterans Health Administration.” J Cataract Refract Surg 49, no. 1 (January 1, 2023): 105–7. https://doi.org/10.1097/j.jcrs.0000000000001086.
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  - Aggarwal, Sahil, C Ellis Wisely, Misha Syed, R Michael Siatkowski, and Pratap Challa. “Learning From the 2021 Ophthalmology Match: Virtual Residency Matching During the COVID-19 Pandemic.” Journal of Graduate Medical Education 14, no. 6 (December 2022): 674–79. https://doi.org/10.4300/jgme-d-22-00186.1.
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  - Choi, Jin A., Rupalatha Maddala, Shruthi Karnam, Nikolai P. Skiba, Robin Vann, Pratap Challa, and Ponugoti Vasantha Rao. “Role of vasorin, an anti-apoptotic, anti-TGF-β and hypoxia-induced glycoprotein in the trabecular meshwork cells and glaucoma.” J Cell Mol Med 26, no. 7 (April 2022): 2063–75. https://doi.org/10.1111/jcmm.17229.
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  - Maddala, Rupalatha, Leona T. Y. Ho, Shruthi Karnam, Iris Navarro, Anja Osterwald, Sandra S. Stinnett, Christoph Ullmer, Robin R. Vann, Pratap Challa, and Ponugoti V. Rao. “Elevated Levels of Growth/Differentiation Factor-15 in the Aqueous Humor and Serum of Glaucoma Patients.” J Clin Med 11, no. 3 (January 29, 2022). https://doi.org/10.3390/jcm11030744.
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  - Aldaas, Khalid, Pratap Challa, David J. Weber, and David Fleischman. “Infections and glaucoma.” Surv Ophthalmol 67, no. 3 (2022): 637–58. https://doi.org/10.1016/j.survophthal.2021.08.009.
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  - Luna, Coralia, Megan Parker, Pratap Challa, and Pedro Gonzalez. “Long-Term Decrease of Intraocular Pressure in Rats by Viral Delivery of miR-146a.” Transl Vis Sci Technol 10, no. 8 (July 1, 2021): 14. https://doi.org/10.1167/tvst.10.8.14.
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  - Sit, Arthur J., Divakar Gupta, Arash Kazemi, Hayley McKee, Pratap Challa, Katy C. Liu, Jae Lopez, Casey Kopczynski, and Theresa Heah. “Netarsudil Improves Trabecular Outflow Facility in Patients with Primary Open Angle Glaucoma or Ocular Hypertension: A Phase 2 Study.” Am J Ophthalmol 226 (June 2021): 262–69. https://doi.org/10.1016/j.ajo.2021.01.019.
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  - Li, Guorong, Chanyoung Lee, A Thomas Read, Ke Wang, Jungmin Ha, Megan Kuhn, Iris Navarro, et al. “Anti-fibrotic activity of a rho-kinase inhibitor restores outflow function and intraocular pressure homeostasis.” Elife 10 (March 30, 2021). https://doi.org/10.7554/eLife.60831.
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  - Chandramouli, Shivram A., Tanya S. Glaser, Obinna Umunakwe, Divakar Gupta, Milica A. Margeta, Pratap Challa, Anthony N. Kuo, and Sharon F. Freedman. “Glaucoma Drainage Devices Calculator App: A Modern Clinical Decision Tool.” Ophthalmol Glaucoma 4, no. 5 (2021): 550–51. https://doi.org/10.1016/j.ogla.2021.01.002.
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  - Li, Ang, Thais F. Conti, Rishi P. Singh, and Pratap Challa. “Infectious and Sterile Endophthalmitis in Eyes with Glaucoma Drainage Device from Two Large Ophthalmic Institutions.” Ophthalmol Glaucoma 4, no. 2 (2021): 193–200. https://doi.org/10.1016/j.ogla.2020.09.003.
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  - Ho, Leona T. Y., Anja Osterwald, Iris Ruf, Daniel Hunziker, Patrizio Mattei, Pratap Challa, Robin Vann, Christoph Ullmer, and Ponugoti Vasanth Rao. “Role of the autotaxin-lysophosphatidic acid axis in glaucoma, aqueous humor drainage and fibrogenic activity.” Biochim Biophys Acta Mol Basis Dis 1866, no. 1 (January 1, 2020): 165560. https://doi.org/10.1016/j.bbadis.2019.165560.
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  - Liu, Katy C., Maria Gomez-Caraballo, Pratap Challa, and Sanjay G. Asrani. “Recurrent Tube Erosions with Anti-Vascular Endothelial Growth Factor Therapy in Patients with Age-Related Macular Degeneration.” Ophthalmol Glaucoma 3, no. 4 (2020): 295–300. https://doi.org/10.1016/j.ogla.2020.04.005.
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  - Thompson, Atalie C., Daniel M. Vu, Eric A. Postel, and Pratap Challa. “Factors Impacting Outcomes and the Time to Recovery From Malignant Glaucoma.” Am J Ophthalmol 209 (January 2020): 141–50. https://doi.org/10.1016/j.ajo.2019.07.023.
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  - Thompson, Atalie C., Daniel M. Vu, Eric Postel, and Pratap Challa. “Reply to Correspondence.” Am J Ophthalmol 209 (January 2020): 215–16. https://doi.org/10.1016/j.ajo.2019.09.001.
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  - Thompson, Atalie C., Daniel M. Vu, Eric Postel, and Pratap Challa. “Comment on: Factors Impacting Outcomes and the Time to Recovery from Malignant Glaucoma Reply.” American Journal of Ophthalmology 209 (January 1, 2020): 215–16.
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  - Genetics of Glaucoma in People of African Descent (GGLAD) Consortium, Chiea Chuen, Michael A. Hauser, R Rand Allingham, Tin Aung, Carly J. Van Der Heide, Kent D. Taylor, Jerome I. Rotter, et al. “Association of Genetic Variants With Primary Open-Angle Glaucoma Among Individuals With African Ancestry.” Jama 322, no. 17 (November 5, 2019): 1682–91. https://doi.org/10.1001/jama.2019.16161.
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  - Rothman, Adam L., Jullia A. Rosdahl, Thomas G. Hunter, Pratap Challa, and Kelly W. Muir. “Treatment Outcomes Following Resident Performed Nonvalved (Baerveldt 350) Glaucoma Drainage Device Implantation.” J Glaucoma 28, no. 11 (November 2019): 958–64. https://doi.org/10.1097/IJG.0000000000001354.
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  - Singman, Eric L., Michael V. Boland, Jing Tian, Laura K. Green, Divya Srikumaran, and Divya Writing Committee of the Ophthalmology Program Directors’ Study Group (OPDSG). “Supervision and autonomy of ophthalmology residents in the outpatient clinic in the United States II: a survey of senior residents.” Bmc Med Educ 19, no. 1 (June 13, 2019): 202. https://doi.org/10.1186/s12909-019-1620-0.
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  - Thompson, Atalie C., and Pratap Challa. “Prophylactic anterior vitrectomy during cataract surgery in eyes at increased risk for aqueous misdirection.” Am J Ophthalmol Case Rep 12 (December 2018): 24–27. https://doi.org/10.1016/j.ajoc.2018.08.002.
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  - Challa, Pratap, and William M. Johnson. “Composition of Exfoliation Material.” J Glaucoma 27 Suppl 1 (July 2018): S29–31. https://doi.org/10.1097/IJG.0000000000000917.
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  - Drewry, Michelle D., Pratap Challa, John G. Kuchtey, Iris Navarro, Inas Helwa, Yanzhong Hu, Hongmei Mu, W Daniel Stamer, Rachel W. Kuchtey, and Yutao Liu. “Differentially expressed microRNAs in the aqueous humor of patients with exfoliation glaucoma or primary open-angle glaucoma.” Hum Mol Genet 27, no. 7 (April 1, 2018): 1263–75. https://doi.org/10.1093/hmg/ddy040.
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  - Rao, Veena, and Pratap Challa. “Author Response, Regarding "Simultaneous Implantation of an Ahmed and Baerveldt Glaucoma Drainage Device for Uncontrolled Intraocular Pressure in Advanced Glaucoma".” J Glaucoma 27, no. 1 (January 2018): e24–25. https://doi.org/10.1097/IJG.0000000000000786.
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  - Aung, Tin, Mineo Ozaki, Mei Chin Lee, Ursula Schlötzer-Schrehardt, Gudmar Thorleifsson, Takanori Mizoguchi, Robert P. Igo, et al. “Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci.” Nat Genet 49, no. 7 (July 2017): 993–1004. https://doi.org/10.1038/ng.3875.
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  - Reina-Torres, Ester, Joanne C. Wen, Katy C. Liu, Guorong Li, Joseph M. Sherwood, Jason Y. H. Chang, Pratap Challa, et al. “VEGF as a Paracrine Regulator of Conventional Outflow Facility.” Invest Ophthalmol Vis Sci 58, no. 3 (March 1, 2017): 1899–1908. https://doi.org/10.1167/iovs.16-20779.
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  - Wen, Joanne C., Ester Reina-Torres, Joseph M. Sherwood, Pratap Challa, Katy C. Liu, Guorong Li, Jason Y. H. Chang, et al. “Intravitreal Anti-VEGF Injections Reduce Aqueous Outflow Facility in Patients With Neovascular Age-Related Macular Degeneration.” Invest Ophthalmol Vis Sci 58, no. 3 (March 1, 2017): 1893–98. https://doi.org/10.1167/iovs.16-20786.
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  - Rao, Veena S., Joseph Christenbury, Paul Lee, Rand Allingham, Leon Herndon, and Pratap Challa. “Simultaneous Implantation of an Ahmed and Baerveldt Glaucoma Drainage Device for Uncontrolled Intraocular Pressure in Advanced Glaucoma.” J Glaucoma 26, no. 2 (February 2017): 101–6. https://doi.org/10.1097/IJG.0000000000000531.
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  - Pasricha, Neel Dave, Paramjit Kaur Bhullar, Christine Shieh, Christian Viehland, Oscar Mijail Carrasco-Zevallos, Brenton Keller, Joseph Adam Izatt, Cynthia Ann Toth, Pratap Challa, and Anthony Nanlin Kuo. “Four-dimensional microscope- integrated optical coherence tomography to enhance visualization in glaucoma surgeries.” Indian J Ophthalmol 65, no. 1 (January 2017): 57–59. https://doi.org/10.4103/ijo.IJO_412_16.
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  - Veerappan, Malini, Garrick Chak, Christine Shieh, and Pratap Challa. “Atypical Presentation of Acute Angle-Closure Glaucoma in Maroteaux-Lamy Mucopolysaccharidosis with Patent Prophylactic Laser Peripheral Iridotomy: A Case Report.” Perm J 21 (2017): 17–012. https://doi.org/10.7812/TPP/17-012.
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  - Boussommier-Calleja, Alexandra, Guorong Li, Amanda Wilson, Tal Ziskind, Oana Elena Scinteie, Nicole E. Ashpole, Joseph M. Sherwood, et al. “Physical Factors Affecting Outflow Facility Measurements in Mice.” Invest Ophthalmol Vis Sci 56, no. 13 (December 2015): 8331–39. https://doi.org/10.1167/iovs.15-17106.
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  - Hauser, Michael A., Inas F. Aboobakar, Yutao Liu, Shiroh Miura, Benjamin T. Whigham, Pratap Challa, Joshua Wheeler, et al. “Genetic variants and cellular stressors associated with exfoliation syndrome modulate promoter activity of a lncRNA within the LOXL1 locus.” Hum Mol Genet 24, no. 22 (November 15, 2015): 6552–63. https://doi.org/10.1093/hmg/ddv347.
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  - Li, Zheng, R Rand Allingham, Masakazu Nakano, Liyun Jia, Yuhong Chen, Yoko Ikeda, Baskaran Mani, et al. “A common variant near TGFBR3 is associated with primary open angle glaucoma.” Hum Mol Genet 24, no. 13 (July 1, 2015): 3880–92. https://doi.org/10.1093/hmg/ddv128.
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  - McNabb, Ryan P., Pratap Challa, Anthony N. Kuo, and Joseph A. Izatt. “Complete 360° circumferential gonioscopic optical coherence tomography imaging of the iridocorneal angle.” Biomed Opt Express 6, no. 4 (April 1, 2015): 1376–91. https://doi.org/10.1364/BOE.6.001376.
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  - Dismuke, W Michael, Pratap Challa, Iris Navarro, W Daniel Stamer, and Yutao Liu. “Human aqueous humor exosomes.” Exp Eye Res 132 (March 2015): 73–77. https://doi.org/10.1016/j.exer.2015.01.019.
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  - Pattabiraman, Padmanabhan P., Tommy Rinkoski, Eric Poeschla, Alan Proia, Pratap Challa, and Ponugoti V. Rao. “RhoA GTPase-induced ocular hypertension in a rodent model is associated with increased fibrogenic activity in the trabecular meshwork.” Am J Pathol 185, no. 2 (February 2015): 496–512. https://doi.org/10.1016/j.ajpath.2014.10.023.
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  - Germano, Renato Antunes Schiave, Simone Finzi, Pratap Challa, and Remo Susanna Junior. “Rho kinase inhibitors for glaucoma treatment - Review.” Arq Bras Oftalmol 78, no. 6 (2015): 388–91. https://doi.org/10.5935/0004-2749.20150103.
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  - Challa, Pratap, and John J. Arnold. “Rho-kinase inhibitors offer a new approach in the treatment of glaucoma.” Expert Opin Investig Drugs 23, no. 1 (January 2014): 81–95. https://doi.org/10.1517/13543784.2013.840288.
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  - Wallace, Dana J., Felix Y. Chau, Cecilia Santiago-Turla, Michael Hauser, Pratap Challa, Paul P. Lee, Leon W. Herndon, and R Rand Allingham. “Osteogenesis imperfecta and primary open angle glaucoma: genotypic analysis of a new phenotypic association.” Mol Vis 20 (2014): 1174–81.
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  - Liu, Yutao, Michael A. Hauser, Stephen K. Akafo, Xuejun Qin, Shiroh Miura, Jason R. Gibson, Joshua Wheeler, et al. “Investigation of known genetic risk factors for primary open angle glaucoma in two populations of African ancestry.” Invest Ophthalmol Vis Sci 54, no. 9 (September 17, 2013): 6248–54. https://doi.org/10.1167/iovs.13-12779.
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  - Li, G., P. Gonzalez, L. J. Camras, I. Navarro, J. Qiu, P. Challa, and W. D. Stamer. “Optimizing gene transfer to conventional outflow cells in living mouse eyes.” Exp Eye Res 109 (April 2013): 8–16. https://doi.org/10.1016/j.exer.2013.01.005.
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  - Arnold, John J., Mark S. Hansen, Gregory S. Gorman, Toshihiro Inoue, Vasantha Rao, Simone Spellen, Ronald N. Hunsinger, et al. “The effect of Rho-associated kinase inhibition on the ocular penetration of timolol maleate.” Invest Ophthalmol Vis Sci 54, no. 2 (February 7, 2013): 1118–26. https://doi.org/10.1167/iovs.12-10583.
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  - Huang, Wei, Guorong Li, Jianming Qiu, Pedro Gonzalez, and Pratap Challa. “Protective effects of resveratrol in experimental retinal detachment.” Plos One 8, no. 9 (2013): e75735. https://doi.org/10.1371/journal.pone.0075735.
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  - Gedde, Steven J., Kuldev Singh, Joyce C. Schiffman, William J. Feuer, and William J. Tube Versus Trabeculectomy Study Group. “The Tube Versus Trabeculectomy Study: interpretation of results and application to clinical practice.” Curr Opin Ophthalmol 23, no. 2 (March 2012): 118–26. https://doi.org/10.1097/ICU.0b013e32834ff2d1.
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  - Iyer, Padma, Robert Lalane, Corey Morris, Pratap Challa, Robin Vann, and Ponugoti Vasantha Rao. “Autotaxin-lysophosphatidic acid axis is a novel molecular target for lowering intraocular pressure.” Plos One 7, no. 8 (2012): e42627. https://doi.org/10.1371/journal.pone.0042627.
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  - Liu, Wenjing, Yutao Liu, Pratap Challa, Leon W. Herndon, Janey L. Wiggs, Christopher A. Girkin, R Rand Allingham, and Michael A. Hauser. “Low prevalence of myocilin mutations in an African American population with primary open-angle glaucoma.” Mol Vis 18 (2012): 2241–46.
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  - Li, Guorong, Coralia Luna, Iris D. Navarro, David L. Epstein, Wei Huang, Pedro Gonzalez, and Pratap Challa. “Resveratrol prevention of oxidative stress damage to lens epithelial cell cultures is mediated by forkhead box O activity.” Invest Ophthalmol Vis Sci 52, no. 7 (June 21, 2011): 4395–4401. https://doi.org/10.1167/iovs.10-6652.
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  - Challa, Pratap. “Genetics of adult glaucoma.” Int Ophthalmol Clin 51, no. 3 (2011): 37–51. https://doi.org/10.1097/IIO.0b013e31821e52fe.
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  - Crooks, Kristy R., R Rand Allingham, Xuejun Qin, Yutao Liu, Jason R. Gibson, Cecilia Santiago-Turla, Karen R. Larocque-Abramson, et al. “Genome-wide linkage scan for primary open angle glaucoma: influences of ancestry and age at diagnosis.” Plos One 6, no. 7 (2011): e21967. https://doi.org/10.1371/journal.pone.0021967.
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  - Liu, Yutao, Jason Gibson, Joshua Wheeler, Lydia Coulter Kwee, Cecile M. Santiago-Turla, Stephen K. Akafo, Paul R. Lichter, et al. “GALC deletions increase the risk of primary open-angle glaucoma: the role of Mendelian variants in complex disease.” Plos One 6, no. 11 (2011): e27134. https://doi.org/10.1371/journal.pone.0027134.
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  - Khan, Tanya T., Guorong Li, Iris D. Navarro, Rama D. Kastury, Carol J. Zeil, Taras M. Semchyshyn, Frank J. Moya, David L. Epstein, Pedro Gonzalez, and Pratap Challa. “LOXL1 expression in lens capsule tissue specimens from individuals with pseudoexfoliation syndrome and glaucoma.” Mol Vis 16 (November 2, 2010): 2236–41.
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  - Gedde, Steven J., Dale K. Heuer, Richard K. Parrish, and Richard K. Tube Versus Trabeculectomy Study Group. “Review of results from the Tube Versus Trabeculectomy Study.” Curr Opin Ophthalmol 21, no. 2 (March 2010): 123–28. https://doi.org/10.1097/ICU.0b013e3283360b68.
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  - Patel, Mrinali, Pratap Challa, and Natalie A. Afshari. “Descemet's stripping automated endothelial keratoplasty in a patient with four glaucoma tubes.” Ann Ophthalmol (Skokie) 42 Spec No (2010): 20–23.
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  - Luna, Coralia, Guorong Li, Jianming Qiu, Pratap Challa, David L. Epstein, and Pedro Gonzalez. “Extracellular release of ATP mediated by cyclic mechanical stress leads to mobilization of AA in trabecular meshwork cells.” Invest Ophthalmol Vis Sci 50, no. 12 (December 2009): 5805–10. https://doi.org/10.1167/iovs.09-3796.
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  - Arnold, John J., Yash Choksi, Xin Chen, Atsushi Shimazaki, John Hatten, Eric J. Toone, David L. Epstein, and Pratap Challa. “Eyedrops containing SA9000 prodrugs result in sustained reductions in intraocular pressure in rabbits.” J Ocul Pharmacol Ther 25, no. 3 (June 2009): 179–86. https://doi.org/10.1089/jop.2008.0107.
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  - Challa, Pratap. “Genetics of pseudoexfoliation syndrome.” Curr Opin Ophthalmol 20, no. 2 (March 2009): 88–91. https://doi.org/10.1097/ICU.0b013e328320d86a.
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  - Luna, Coralia, Guorong Li, Paloma B. Liton, Jianming Qiu, David L. Epstein, Pratap Challa, and Pedro Gonzalez. “Resveratrol prevents the expression of glaucoma markers induced by chronic oxidative stress in trabecular meshwork cells.” Food Chem Toxicol 47, no. 1 (January 2009): 198–204. https://doi.org/10.1016/j.fct.2008.10.029.
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  - Muir, Kelly W., Cecilia Santiago-Turla, Sandra S. Stinnett, Leon W. Herndon, R Rand Allingham, Pratap Challa, and Paul P. Lee. “Glaucoma patients' trust in the physician.” J Ophthalmol 2009 (2009): 476726. https://doi.org/10.1155/2009/476726.
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  - Stein, Joshua D., Allison N. McCoy, Sanjay Asrani, Leon W. Herndon, Paul P. Lee, Stuart J. McKinnon, R Rand Allingham, and Pratap Challa. “Surgical management of hypotony owing to overfiltration in eyes receiving glaucoma drainage devices.” J Glaucoma 18, no. 8 (2009): 638–41. https://doi.org/10.1097/IJG.0b013e31819aa4e0.
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  - Liu, Yutao, Silke Schmidt, Xuejun Qin, Jason Gibson, Kristen Hutchins, Cecile Santiago-Turla, Janey L. Wiggs, et al. “Lack of association between LOXL1 variants and primary open-angle glaucoma in three different populations.” Invest Ophthalmol Vis Sci 49, no. 8 (August 2008): 3465–68. https://doi.org/10.1167/iovs.08-1850.
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  - Muir, K. W., C. Santiago-Turla, S. S. Stinnett, L. W. Herndon, R. R. Allingham, P. Challa, and P. P. Lee. “Health literacy and vision-related quality of life.” Br J Ophthalmol 92, no. 6 (June 2008): 779–82. https://doi.org/10.1136/bjo.2007.134452.
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  - Jagadeesan, Raja, Dev N. Kalyan, Paul Lee, Sandra Stinnett, and Pratap Challa. “Use of a standardized patient satisfaction questionnaire to assess the quality of care provided by ophthalmology residents.” Ophthalmology 115, no. 4 (April 2008): 738-743.e3. https://doi.org/10.1016/j.ophtha.2007.05.033.
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  - Challa, Pratap, Silke Schmidt, Yutao Liu, Xuejun Qin, Robin R. Vann, Pedro Gonzalez, R Rand Allingham, and Michael A. Hauser. “Analysis of LOXL1 polymorphisms in a United States population with pseudoexfoliation glaucoma.” Mol Vis 14 (January 29, 2008): 146–49.
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  - Challa, Pratap. “Glaucoma genetics.” Int Ophthalmol Clin 48, no. 4 (2008): 73–94. https://doi.org/10.1097/IIO.0b013e318187e71a.
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  - Liu, Xialin, Min Zhang, Yuhua Liu, Pratap Challa, Pedro Gonzalez, and Yizhi Liu. “Proteomic analysis of regenerated rabbit lenses reveal crystallin expression characteristic of adult rabbits.” Mol Vis 14 (2008): 2404–12.
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  - Liu, Yutao, Stephen Akafo, Cecile Santiago-Turla, Claudia S. Cohen, Karen R. Larocque-Abramson, Xuejun Qin, Leon W. Herndon, et al. “Optineurin coding variants in Ghanaian patients with primary open-angle glaucoma.” Mol Vis 14 (2008): 2367–72.
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  - Stein, Joshua D., Leon W. Herndon, J. Brent Bond, and Pratap Challa. “Exposure of Ex-PRESS Miniature Glaucoma Devices: case series and technique for tube shunt removal.” J Glaucoma 16, no. 8 (December 2007): 704–6. https://doi.org/10.1097/IJG.0b013e31806ab314.
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  - Stein, Joshua D., and Pratap Challa. “Mechanisms of action and efficacy of argon laser trabeculoplasty and selective laser trabeculoplasty.” Curr Opin Ophthalmol 18, no. 2 (March 2007): 140–45. https://doi.org/10.1097/ICU.0b013e328086aebf.
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  - Lin, Cheng-Wen, Yong Wang, Pratap Challa, David L. Epstein, and Fan Yuan. “Transscleral diffusion of ethacrynic acid and sodium fluorescein.” Mol Vis 13 (February 22, 2007): 243–51.
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  - Gedde, Steven J., Joyce C. Schiffman, William J. Feuer, Leon W. Herndon, James D. Brandt, and Donald L. Budenz. “Treatment outcomes in the tube versus trabeculectomy study after one year of follow-up.” Am J Ophthalmol 143, no. 1 (January 2007): 9–22. https://doi.org/10.1016/j.ajo.2006.07.020.
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  - Gedde, Steven J., Leon W. Herndon, James D. Brandt, Donald L. Budenz, William J. Feuer, and Joyce C. Schiffman. “Surgical complications in the Tube Versus Trabeculectomy Study during the first year of follow-up.” Am J Ophthalmol 143, no. 1 (January 2007): 23–31. https://doi.org/10.1016/j.ajo.2006.07.022.
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  - Challa, Pratap, Michael Arthur Hauser, Coralia Catalina Luna, Sharon Fridovich Freedman, Margaret Pericak-Vance, Jun Yang, Marie Theresa McDonald, and R Rand Allingham. “Juvenile bilateral lens dislocation and glaucoma associated with a novel mutation in the fibrillin 1 gene.” Mol Vis 12 (August 28, 2006): 1009–15.
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  - Muir, Kelly W., Cecile Santiago-Turla, Sandra S. Stinnett, Leon W. Herndon, R Rand Allingham, Pratap Challa, and Paul P. Lee. “Health literacy and adherence to glaucoma therapy.” Am J Ophthalmol 142, no. 2 (August 2006): 223–26. https://doi.org/10.1016/j.ajo.2006.03.018.
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  - Liton, Paloma B., Coralia Luna, Pratap Challa, David L. Epstein, and Pedro Gonzalez. “Genome-wide expression profile of human trabecular meshwork cultured cells, nonglaucomatous and primary open angle glaucoma tissue.” Mol Vis 12 (July 12, 2006): 774–90.
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  - Liton, P. B., X. Liu, P. Challa, D. L. Epstein, and P. Gonzalez. “Induction of TGF-beta1 in the trabecular meshwork under cyclic mechanical stress.” J Cell Physiol 205, no. 3 (December 2005): 364–71. https://doi.org/10.1002/jcp.20404.
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  - Whited, John D., Santanu K. Datta, Lloyd M. Aiello, Lloyd P. Aiello, Jerry D. Cavallerano, Paul R. Conlin, Mark B. Horton, et al. “A modeled economic analysis of a digital tele-ophthalmology system as used by three federal health care agencies for detecting proliferative diabetic retinopathy.” Telemed J E Health 11, no. 6 (December 2005): 641–51. https://doi.org/10.1089/tmj.2005.11.641.
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  - Song, Julia, Paul P. Lee, David L. Epstein, Sandra S. Stinnett, Leon W. Herndon, Sanjay G. Asrani, R Rand Allingham, and Pratap Challa. “High failure rate associated with 180 degrees selective laser trabeculoplasty.” J Glaucoma 14, no. 5 (October 2005): 400–408. https://doi.org/10.1097/01.ijg.0000176939.43681.c2.
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  - Gedde, Steven J., Joyce C. Schiffman, William J. Feuer, Richard K. Parrish, Dale K. Heuer, James D. Brandt, and James D. Tube Versus Trabeculectomy Study Group. “The tube versus trabeculectomy study: design and baseline characteristics of study patients.” Am J Ophthalmol 140, no. 2 (August 2005): 275–87. https://doi.org/10.1016/j.ajo.2005.03.031.
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  - Challa, Pratap, Coralia Luna, Paloma B. Liton, Beth Chamblin, John Wakefield, Ram Ramabhadran, David L. Epstein, and Pedro Gonzalez. “Lentiviral mediated gene delivery to the anterior chamber of rodent eyes.” Mol Vis 11 (June 21, 2005): 425–30.
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  - Liton, Paloma B., Pratap Challa, Sandra Stinnett, Coralia Luna, David L. Epstein, and Pedro Gonzalez. “Cellular senescence in the glaucomatous outflow pathway.” Exp Gerontol 40, no. 8–9 (2005): 745–48. https://doi.org/10.1016/j.exger.2005.06.005.
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  - Liton, Paloma B., Xialin Liu, W Daniel Stamer, Pratap Challa, David L. Epstein, and Pedro Gonzalez. “Specific targeting of gene expression to a subset of human trabecular meshwork cells using the chitinase 3-like 1 promoter.” Invest Ophthalmol Vis Sci 46, no. 1 (January 2005): 183–90. https://doi.org/10.1167/iovs.04-0330.
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  - Song, Julia, Paul P. Lee, Richard Weiner, and Pratap Challa. “The effect of surgery on intraocular pressure fluctuations with electroconvulsive therapy in a patient with severe glaucoma.” J Ect 20, no. 4 (December 2004): 264–66. https://doi.org/10.1097/00124509-200412000-00015.
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  - Caballero, Montserrat, Paloma B. Liton, Pratap Challa, David L. Epstein, and Pedro Gonzalez. “Effects of donor age on proteasome activity and senescence in trabecular meshwork cells.” Biochem Biophys Res Commun 323, no. 3 (October 22, 2004): 1048–54. https://doi.org/10.1016/j.bbrc.2004.08.195.
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  - Singh, Inder P., Sameer I. Ahmad, David Yeh, Pratap Challa, Leon W. Herndon, R Rand Allingham, and Paul P. Lee. “Early rapid rise in intraocular pressure after intravitreal triamcinolone acetonide injection.” Am J Ophthalmol 138, no. 2 (August 2004): 286–87. https://doi.org/10.1016/j.ajo.2004.03.001.
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  - Wang, Yong, Pratap Challa, David L. Epstein, and Fan Yuan. “Controlled release of ethacrynic acid from poly(lactide-co-glycolide) films for glaucoma treatment.” Biomaterials 25, no. 18 (August 2004): 4279–85. https://doi.org/10.1016/j.biomaterials.2003.10.075.
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  - Challa, Pratap. “Glaucoma genetics: advancing new understandings of glaucoma pathogenesis.” Int Ophthalmol Clin 44, no. 2 (2004): 167–85. https://doi.org/10.1097/00004397-200404420-00011.
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  - Herndon, Leon W., Pratap Challa, and R Rand Allingham. “Glaucoma in Ghana, West Africa: clinical features and the role of mutations in Myocilin.” Ophthalmol Clin North Am 16, no. 4 (December 2003): 631–37. https://doi.org/10.1016/s0896-1549(03)00070-1.
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  - Asrani, Sanjay, Pratap Challa, Leon Herndon, Paul Lee, Sandra Stinnett, and R Rand Allingham. “Correlation among retinal thickness, optic disc, and visual field in glaucoma patients and suspects: a pilot study.” J Glaucoma 12, no. 2 (April 2003): 119–28. https://doi.org/10.1097/00061198-200304000-00006.
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  - Khurana, Rahul N., Paul P. Lee, and Pratap Challa. “Readability of ocular medication inserts.” J Glaucoma 12, no. 1 (February 2003): 50–53. https://doi.org/10.1097/00061198-200302000-00010.
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  - Cohen, Shawn L., Paul P. Lee, Leon W. Herndon, Pratap Challa, Olga Overbury, and R Rand Allingham. “Using the arteriolar Pressure Attenuation Index to predict ocular hypertension progression to open-angle glaucoma.” Arch Ophthalmol 121, no. 1 (January 2003): 33–38. https://doi.org/10.1001/archopht.121.1.33.
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  - Challa, P., L. W. Herndon, M. A. Hauser, B. W. Broomer, M. A. Pericak-Vance, Ben Ababio-Danso, and R. R. Allingham. “Prevalence of myocilin mutations in adults with primary open-angle glaucoma in Ghana, West Africa.” J Glaucoma 11, no. 5 (October 2002): 416–20. https://doi.org/10.1097/00061198-200210000-00008.
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  - Herndon, Leon W., Pratap Challa, Ben Ababio-Danso, John O. Boateng, Bob Broomer, Philip Ridenhour, and R Rand Allingham. “Survey of glaucoma in an eye clinic in Ghana, West Africa.” J Glaucoma 11, no. 5 (October 2002): 421–25. https://doi.org/10.1097/00061198-200210000-00009.
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  - Herndon, Leon W., Sanjay G. Asrani, Gayle H. Williams, Pratap Challa, and Paul P. Lee. “Paradoxical intraocular pressure elevation after combined therapy with latanoprost and bimatoprost.” Arch Ophthalmol 120, no. 6 (June 2002): 847–49.
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  - Allingham, R. R., B. Seo, E. Rampersaud, M. Bembe, P. Challa, N. Liu, T. Parrish, et al. “A duplication in chromosome 4q35 is associated with hereditary benign intraepithelial dyskeratosis.” Am J Hum Genet 68, no. 2 (February 2001): 491–94. https://doi.org/10.1086/318194.
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  - Fanous, M. M., P. Challa, and T. H. Maren. “Comparison of intraocular pressure lowering by topical and systemic carbonic anhydrase inhibitors in the rabbit.” J Ocul Pharmacol Ther 15, no. 1 (February 1999): 51–57. https://doi.org/10.1089/jop.1999.15.51.
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- Book Sections
  - Challa, P. “Early Postoperative Increase in Intraocular Pressure.” In Glaucoma: Second Edition, 2:805–10, 2015. https://doi.org/10.1016/B978-0-7020-5193-7.00080-7.
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  - Challa, Pratap, and David L. Epstein. “Pseudoexfoliation Syndrome and Open-Angle Glaucoma.” In CHANDLER AND GRANT’S GLAUCOMA, FIFTH EDITION, 217–25, 2013.
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  - Challa, Pratap, and David L. Epstein. “Adrenergic Agents Blockers and Agonists.” In CHANDLER AND GRANT’S GLAUCOMA, FIFTH EDITION, 133–47, 2013.
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  - Challa, Pratap, and David L. Epstein. “Carbonic Anhydrase Inhibitors Systemic Use.” In CHANDLER AND GRANT’S GLAUCOMA, FIFTH EDITION, 159–64, 2013.
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  - Challa, Pratap, and David L. Epstein. “The Miotics.” In CHANDLER AND GRANT’S GLAUCOMA, FIFTH EDITION, 149–57, 2013.
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  - Challa, Pratap, and Joel S. Schuman. “Topical Carbonic Anhydrase Inhibitors.” In CHANDLER AND GRANT’S GLAUCOMA, FIFTH EDITION, 165–69, 2013.
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  - Chau, F. Y., D. Wallace, T. Vajaranant, L. Herndon, P. Lee, P. Challa, R. Allingham, and I. Maumenee. “Osteogenesis Imperfecta and the Eye.” In Osteogenesis Imperfecta: A Translational Approach to Brittle Bone Disease, 289–303, 2013. https://doi.org/10.1016/B978-0-12-397165-4.00031-9.
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  - Stein, Joshua D., R Rand Allingham, and Pratap Challa. “Management of Highly Elevated Intraocular Pressure.” In CHANDLER AND GRANT’S GLAUCOMA, FIFTH EDITION, 177–82, 2013.
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- Other Articles
  - Aung, Tin, Mineo Ozaki, Takanori Mizoguchi, R Rand Allingham, Zheng Li, Aravind Haripriya, Satoko Nakano, et al. “Corrigendum: a common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome.” Nat Genet, June 2015. https://doi.org/10.1038/ng0615-689c.
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  - Challa, P., P. Lee, D. Epstein, S. Stinnett, L. Herndon, S. Asrani, and R. Allingham. “In response [3].” Journal of Glaucoma, March 1, 2007. https://doi.org/10.1097/IJG.0b013e318039baf1.
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  - Agrawal, Shishir, Jaya Agrawal, and Trilok P. Agrawal. “Management of intractable glaucoma following intravitreal triamcinolone acetonide.” Am J Ophthalmol, March 2005. https://doi.org/10.1016/j.ajo.2004.10.025.
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- Conference Papers
  - Challa, Pratap, Rupalatha Maddala, Leona Ho, Shruthi Karnam, Anja Osterwald, Sandra S. Stinnett, Robin Vann, Christoph Ullmer, and Vasantha Rao. “Elevated levels of GDF-15 in both the Aqueous Humor and Serum of Primary Open-Angle Glaucoma Patients.” In Investigative Ophthalmology & Visual Science, Vol. 62, 2021.
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  - Choi, Jin A., Shruthi Karnam, Nikolai Skiba, Rupalatha Maddala, Pratap Challa, Robin Vann, and Vasantha Rao. “Vasorin, an antagonist of TGF-beta is decreased in glaucoma patients.” In Investigative Ophthalmology & Visual Science, Vol. 62, 2021.
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  - Ethier, C Ross, Guorong Li, Chanyoung Lee, A Thomas Read, Ke Wang, Iris D. Navarro, Jenny Cui, et al. “Netarsudil (NT) restores trabecular meshwork (TM) function/stiffness and reduces IOP in steroid-induced ocular hypertension (OHT).” In Investigative Ophthalmology & Visual Science, Vol. 61, 2020.
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  - Ho, Leona, Pratap Challa, Robin Vann, Christoph Ullmer, and Vasanth Rao. “Elevated Levels of GDF-15 in Aqueous Humor Are Positively Correlated with Increased Intraocular Pressure in Primary Open Angle Glaucoma Patients.” In Investigative Ophthalmology & Visual Science, Vol. 60. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2019.
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  - Luna, Coralia, Pratap Challa, Ursula Schlotzer-Schrehardt, and Pedro Gonzalez. “Generation of Reversible Immortalized Cell Lines to Model Pseudoexfoliation Syndrome.” In Investigative Ophthalmology & Visual Science, Vol. 60. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2019.
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  - Ho, Leona, Anja Osterwald, Solveig Badillo, Iris Ruf, Pratap Challa, Robin Vann, Vasanth Rao, and Christoph Ullmer. “Dysregulation of the Autotaxin/LPA Signaling Axis in the Aqueous Humor of Human Glaucoma Patients.” In Investigative Ophthalmology & Visual Science, Vol. 59. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2018.
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  - Drewry, Michelle, John Kuchtey, Iris Navarro, Shruti Sharma, W Daniel Stamer, Ashok Sharma, Pratap Challa, Rachel W. Kuchtey, and Yutao Liu. “Differentially expressed microRNAs in the aqueous humor of patients with exfoliation glaucoma or primary open-angle glaucoma.” In Investigative Ophthalmology & Visual Science, Vol. 58. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2017.
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  - Khine, Kay T., Abhilash Guduru, Pratap Challa, and David Fleischman. “The influence of intraocular pressure on the severity of diabetic retinopathy.” In Investigative Ophthalmology & Visual Science, Vol. 58. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2017.
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  - Luna, Coralia C., Megan Parker, Pratap Challa, and Pedro Gonzalez. “Evaluation of the potential of iPSCs as a tool to study Pseudoexfoliation Syndrome.” In Investigative Ophthalmology & Visual Science, Vol. 58. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2017.
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  - Bhullar, Paramiit K., Neel D. Pasricha, Oscar M. Zevallos-Carrasco, Christian Viehland, Brenton Keller, Melissa B. Daluvoy, Pratap Challa, et al. “4D Microscope-Integrated OCT to Visualize Depth-Related Steps During Anterior Segment and External Eye Procedures.” In Investigative Ophthalmology & Visual Science, Vol. 57. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2016.
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  - Challa, Pratap, Guorong Li, Coralia Catalina Luna, and Pedro Gonzalez. “Elevated Intraocular Pressures from a Conditional Knockout of the Dicer Gene in the Rodent Trabecular Meshwork.” In Investigative Ophthalmology & Visual Science, Vol. 57. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2016.
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  - Rao, Veena, Joseph Christenbury, Paul P. Lee, Leon W. Herndon, and Pratap Challa. “Simultaneous Implantation of Two Glaucoma Drainage Devices for Uncontrolled Advanced Glaucoma.” In Investigative Ophthalmology & Visual Science, Vol. 55. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2014.
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  - Rothman, Adam L., Neil A. Delwadia, Raju Sarwal, Sandra S. Stinnett, Paul P. Lee, Leon W. Herndon, and Pratap Challa. “A Comparison of Topical Steroids Versus Non-Steroidal Anti-Inflammatory Drugs after Selective Laser Trabeculoplasty.” In Investigative Ophthalmology & Visual Science, Vol. 55. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2014.
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  - Wen, Joanne C., Darryl R. Overby, Michael Madekurozwa, Brian Chu, Priyatham S. Mettu, Stefanie G. Schuman, Pratap Challa, Scott W. Cousins, and R Rand Allingham. “The effect of anti-VEGF injections on tonographic aqueous outflow facility and a novel method to calculate facility using the post-injection IOP decay curve.” In Investigative Ophthalmology & Visual Science, Vol. 55. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2014.
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  - Huang, Wei, Guorong Li, Jianming Qiu, Pedro Gonzalez, and Pratap Challa. “The Protective effects of Resveratrol in Experimental Retinal Detachment.” In Investigative Ophthalmology & Visual Science, Vol. 54. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2013.
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  - Li, Guorong, Mohammadali Almasieh, Coralia Luna, Jianming Qiu, Pratap Challa, Molly Walsh, Henry Tseng, David Epstein, Adriana Di Polo, and Pedro Gonzalez. “Upregulation of miR-146a in retina in rodent models of elevated intraocular pressure.” In Investigative Ophthalmology & Visual Science, Vol. 54. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2013.
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  - Luna, Coralia, Benjamin tenOever, Guorong Li, Sonja Schmid, Pratap Challa, David Epstein, Jianming Qiu, and Pedro Gonzalez. “Evaluation of Influenza Associated Virus (IAV)-based replication-incompetent for Ocular Delivery of microRNAS.” In Investigative Ophthalmology & Visual Science, Vol. 54. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2013.
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  - Rogers, Morgan, Iris Navarro, Kristin Perkumas, R Rand Allingham, Pratap Challa, Craig Crosson, and W Daniel Stamer. “PEDF Effects on Outflow Facility.” In Investigative Ophthalmology & Visual Science, Vol. 54. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2013.
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  - Rosdahl, Jullia, Guorong Li, Jianming Qiu, Pedro Gonzalez, and Pratap Challa. “FOXOs in the Mouse Visual System.” In Investigative Ophthalmology & Visual Science, Vol. 54. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2013.
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  - Camras, L. J., I. D. Navarro, G. Li, J. Qiu, P. Challa, C. Luna, D. L. Epstein, and P. Gonzalez. “In vivo Viral Infusion Method for Gene Delivery to Trabecular Meshwork Cells in Rat Eyes.” In Investigative Ophthalmology & Visual Science, Vol. 51. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2010.
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  - Challa, P., L. J. Camras, I. D. Navarro, C. C. Luna, G. Li, G. K. Klintworth, D. L. Epstein, and P. Gonzalez. “The Anterior Segment Effects of a Conditional Dicer Knockout in a Rodent Model.” In Investigative Ophthalmology & Visual Science, Vol. 51. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2010.
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  - Huang, W., J. Qiu, I. Navarro, P. Gonzalez, and P. Challa. “FOXO Protein Expression is Down-Regulated With Aging in the Lens.” In Investigative Ophthalmology & Visual Science, Vol. 51. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2010.
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  - Khan, T., I. D. Navarro, R. Kastury, P. Gonzalez, and P. Challa. “Analysis of LOXL1 Expression in Lens Capsule Tissue Specimens From Individuals With Pseudoexfoliation and Primary Open-Angle Glaucoma.” In Investigative Ophthalmology & Visual Science, Vol. 51. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2010.
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  - Lalane, R. A., P. Challa, R. Vann, and P. V. Rao. “Aqueous Humor Derived From Human Patients With Primary Open-Angle Glaucoma Contains Increased Levels of Secretory Gelsolin.” In Investigative Ophthalmology & Visual Science, Vol. 51. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2010.
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  - Lee, Paul P., R Rand Allingham, Pratap Challa, Leon W. Herndon, and Inder P. Singh. “Author reply.” In American Journal of Ophthalmology, 139:576–576. Elsevier BV, 2005. https://doi.org/10.1016/j.ajo.2004.10.024.
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  - Arnold, J. J., P. Challa, and D. L. Epstein. “Novel anti-glaucoma formulations of ethacrynic acid containing chitosan.” In Investigative Ophthalmology & Visual Science, Vol. 46. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2005.
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  - Challa, P., N. Wagle, M. A. Hauser, S. H. Freedman, M. Pericak-Vance, M. M. McDonald, C. C. Luna, and R. R. Allingham. “Juvenile bilateral lens dislocation, corneal guttatae, and glaucoma associated with a novel mutation in the FBN1 gene.” In Investigative Ophthalmology & Visual Science, Vol. 46. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2005.
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  - Gonzalez, P., P. B. Liton, C. Luna, P. Challa, and D. L. Epstein. “Genome-wide microarray analysis of the gene expression profile of normal and primary open angle glaucoma human trabecular meshwork (HTM) tissue and cultured HTM cells.” In Investigative Ophthalmology & Visual Science, Vol. 46. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2005.
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  - Challa, P., P. Gonzalez, P. B. Liton, W. Wang, B. Chamblin, J. Wakefield, R. Ramabhadran, and D. L. Epstein. “Gene transfer to the trabecular meshwork and anterior segment of living rat eyes using lentiviral vectors.” In Investigative Ophthalmology & Visual Science, 45:U776–U776. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2004.
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  - Cohen, C. S., P. Challa, L. W. Herndon, M. Pericak-Vance, K. Abramson, M. Hauser, J. Wiggs, and R. R. Allingham. “Prevalence of optineurin mutations in adults with primary open angle glaucoma in Ghana, West Africa.” In Investigative Ophthalmology & Visual Science, 45:U483–U483. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2004.
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  - Gonzalez, P., P. B. Liton, M. Caballero, P. Challa, W. Wang, and D. L. Epstein. “Stress-induced proteasome inhibition and cellular senescence in trabecular meshwork cells, and their potential roles in glaucoma pathophysiology.” In Investigative Ophthalmology & Visual Science, 45:U435–U435. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2004.
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  - Liton, P. B., P. Challa, X. Liu, M. Caballero, W. D. Stamer, and D. L. Epstein. “Specific targeting of gene expression to a subset of human trabecular meshwork cells using the chitinase-3-like-1 promoter in adenoviral-mediated gene transfer experiments.” In Investigative Ophthalmology & Visual Science, 45:U432–U432. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2004.
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  - Liu, X., P. Gonzalez, P. B. Liton, P. Challa, M. Bodman, and D. L. Epstein. “Induction of the TGF-beta-1 gene promoter in the trabecular meshwork after mechanical stress: potential implications in glaucoma pathophysiology.” In Investigative Ophthalmology & Visual Science, 45:U188–U188. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2004.
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  - Challa, P., P. Gonzalez, P. B. Liton, M. Caballero, and D. L. Epstein. “Gene expression profile in a novel cell type in primary cultures of human trabecular meshwork.” In Investigative Ophthalmology & Visual Science, 44:U131–U131. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2003.
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  - Challa, P., P. Gonzalez, R. R. Allingham, D. L. Epstein, and C. B. Rickman. “Identification of genes differentially expressed in individuals with pseudoexfoliation syndrome.” In Investigative Ophthalmology & Visual Science, 43:U1157–U1157. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2002.
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  - Gonzalez, P., P. Challa, M. Caballero, and D. L. Epstein. “Generation of gene arrays from human trabecular meshwork cDNA libraries.” In Investigative Ophthalmology & Visual Science, 43:U1137–U1137. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2002.
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  - Greenman, H. S., L. W. Herndon, D. L. Epstein, S. S. Stinnett, and P. Challa. “The effects of drying on central corneal thickness.” In Investigative Ophthalmology & Visual Science, 43:U53–U53. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2002.
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  - Hu, G., P. Challa, T. Kim, and A. Carlson. “Nomogram-guided adjustment of IOP measurement following LASIK for myopia, based on the amount of refractive correction.” In Investigative Ophthalmology & Visual Science, 43:U483–U483. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2002.
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  - Li, J., P. P. Lee, S. Buckley, S. S. Stinnett, R. R. Allingham, and P. Challa. “Attitudes toward genetic testing for glaucoma: A survey of patients.” In Investigative Ophthalmology & Visual Science, 43:U236–U236. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2002.
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  - Miele, D. L., L. Herndon, P. Lee, S. Stinnett, S. Asrani, R. R. Allingham, and P. C. Challa. “Early clinical experience with the ahmed glaucoma bi-plate.” In Investigative Ophthalmology & Visual Science, 43:U234–U234. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2002.
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  - LaRocque, K. R., R. R. Allingham, M. A. Hauser, L. W. Herndon, B. W. Broomer, M. A. Pericak-Vance, and P. Challa. “Novel myocilin mutations in West African individuals with primary open angle glaucoma.” In American Journal of Human Genetics, 69:563–563. UNIV CHICAGO PRESS, 2001.
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  - Challa, P., M. A. Hauser, L. W. Herndon, B. W. Broomer, M. A. Pericak-Vance, and R. R. Allingham. “Novel myocilin mutations in individuals with POAG from West Africa.” In Investigative Ophthalmology & Visual Science, 42:S562–S562. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2001.
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  - Cohen, S. L., P. P. Lee, L. W. Herndon, P. Challa, O. Overbury, and R. R. Allingham. “The Pressure Attenuation Index (PAI) predicts ocular hypertension progression to open angle glaucoma.” In Investigative Ophthalmology & Visual Science, 42:S20–S20. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2001.
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  - Herndon, L. W., B. Ababio-Danso, J. O. Boateng, P. Challa, B. Broomer, P. Ridenhour, and R. R. Allingham. “Types of glaucoma in a Ghanaian clinic.” In Investigative Ophthalmology & Visual Science, 42:S155–S155. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2001.
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  - Challa, P., G. K. Klintworth, B. Seo, M. Bembe, E. Rampersaud, T. Parrish, J. Gilbert, M. A. Pericak-Vance, J. M. Vance, and R. R. Allingham. “Phenotypic characteristics of hereditary benign intraepithelial dyskeratosis (HBID).” In American Journal of Human Genetics, 67:135–135. UNIV CHICAGO PRESS, 2000.
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  - Vance, J. M., R. R. Allingham, B. Seo, E. Rampersaud, M. L. Bembe, P. Challa, T. Parrish, J. R. Gilbert, M. A. Pericak-Vance, and G. K. Klintworth. “A small duplication of the terminal region of chromosome 4q35 is associated with hereditary benign intraepithelial dyskeratosis.” In American Journal of Human Genetics, 67:20–20. UNIV CHICAGO PRESS, 2000.
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  - Challa, P., M. A. Hauser, M. A. Pericak-Vance, and R. R. Allingham. “Genetic mapping of a syndrome of early-onset lens dislocation.” In Investigative Ophthalmology & Visual Science, 41:S32–S32. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2000.
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  - O’Neal, K. D., T. A. Cox, P. Challa, L. W. Herndon, R. R. Allinham, and P. P. Lee. “Who comes to community eye screenings? A survey.” In Investigative Ophthalmology & Visual Science, 41:S591–S591. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2000.
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  - Challa, P., N. S. Wagle, S. F. Freedman, M. T. McDonald, and R. R. Allingham. “A novel inherited syndrome of early lens dislocation.” In Investigative Ophthalmology & Visual Science, 40:S888–S888. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 1999.
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  - Challa, P., J. R. Guy, C. D. Dickel, and W. H. Hauswirth. “Variations in phenotypic expression of the 11778 mutation in a family with Leber's hereditary optic neuropathy.” In Investigative Ophthalmology & Visual Science, 38:3709–3709. LIPPINCOTT-RAVEN PUBL, 1997.
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