Scholars@Duke
Pratap Challa

Pratap Challa

Professor of Ophthalmology
Ophthalmology, Glaucoma
chall001@mc.duke.edu
Box 3802 Med Ctr, Durham, NC 27710
Wadsworth Bldg, Durham, NC 27710

Overview

As a physician-scientist investigator, Dr. Challa has a special research interest in the genetic basis of inherited eye diseases. He has active projects investigating the genetics of Pseudoexfoliation associated glaucoma and the cellular basis for glaucoma development. He also studies ocular drug delivery and is involved in developing long-term delivery devices for glaucoma medications. He also investigates novel compounds that may eventually be used for treating glaucoma. In addition to basic science research, he also has clinical research interests including evaluating the effectiveness of new glaucoma therapies.

Current Appointments & Affiliations

Professor of Ophthalmology · 2022 - Present Ophthalmology, Glaucoma, Ophthalmology

Recent Publications

Special Commentary: Reporting Clinical Endpoints in Studies of Minimally Invasive Glaucoma Surgery.

Journal Article Ophthalmology · February 2025 Minimally invasive glaucoma surgery (MIGS) refers to a group of procedures generally characterized by an ab interno approach, minimal trauma to ocular tissue, moderate efficacy, an excellent safety profile, and rapid recovery. The number of MIGS procedures ... Full text Cite

Reply.

Journal Article Ophthalmology · February 2025 Full text Cite

Dysregulation of septin cytoskeletal organization in the trabecular meshwork contributes to ocular hypertension.

Journal Article JCI Insight · December 6, 2024 Ocular hypertension, believed to result partly from increased contractile activity, cell adhesive interactions, and stiffness within the trabecular meshwork (TM), is a major risk factor for glaucoma, a leading cause of blindness. However, the identity of m ... Full text Link to item Cite
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Recent Grants

Role of Glypicans in Aqueous Humor Outflow, IOP and Glaucoma

ResearchCo Investigator · Awarded by National Institutes of Health · 2024 - 2028

Assessment of intravitreal implant degradation over time

ResearchPrincipal Investigator · Awarded by Alcon Research · 2024 - 2026

Role of Septin Cytoskeleton in Trabecular Meshwork, IOP and Glaucoma

ResearchCo-Principal Investigator · Awarded by BrightFocus Foundation · 2023 - 2025

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Education, Training & Certifications

University of Florida · 1993 M.D.