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Platelet binding and activity of recombinant factor VIIa.

Publication ,  Journal Article
Hoffman, M; Monroe, DM
Published in: Thromb Res
April 2010

Recombinant FVIIa was developed for the purpose of treating hemophiliacs with antibody inhibitors. It was initially assumed to act by enhancing factor X activation by a tissue factor-dependent mechanism. However, the very high levels of FVIIa required for hemostatic effect in vivo seemed inconsistent with this mechanism. After many years of debate, in now appears that platelet surface binding and activity play an important role in the efficacy of FVIIa as a bypassing agent in hemophilia. Platelet binding was initially suggested to be mediated by binding to anionic phospholipid exposed on platelet surfaces upon activation. It now appears that the glycoprotein Ib/IX/V complex also plays a role in FVIIa binding to platelets. However, the characteristics of FVIIa binding to GPIb/IX/V to not seem to fully explain platelet localization of FVIIa to platelets. Thus, there are still unanswered questions in fully understanding the mechanism of hemostatic action of recombinant FVIIa.

Duke Scholars

Published In

Thromb Res

DOI

EISSN

1879-2472

Publication Date

April 2010

Volume

125 Suppl 1

Start / End Page

S16 / S18

Location

United States

Related Subject Headings

  • Thrombin
  • Recombinant Proteins
  • Protein Binding
  • Platelet Activation
  • Phospholipids
  • Models, Biological
  • Lipids
  • Humans
  • Hemostasis
  • Hemophilia A
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hoffman, M., & Monroe, D. M. (2010). Platelet binding and activity of recombinant factor VIIa. Thromb Res, 125 Suppl 1, S16–S18. https://doi.org/10.1016/j.thromres.2010.01.025
Hoffman, Maureane, and Dougald M. Monroe. “Platelet binding and activity of recombinant factor VIIa.Thromb Res 125 Suppl 1 (April 2010): S16–18. https://doi.org/10.1016/j.thromres.2010.01.025.
Hoffman M, Monroe DM. Platelet binding and activity of recombinant factor VIIa. Thromb Res. 2010 Apr;125 Suppl 1:S16–8.
Hoffman, Maureane, and Dougald M. Monroe. “Platelet binding and activity of recombinant factor VIIa.Thromb Res, vol. 125 Suppl 1, Apr. 2010, pp. S16–18. Pubmed, doi:10.1016/j.thromres.2010.01.025.
Hoffman M, Monroe DM. Platelet binding and activity of recombinant factor VIIa. Thromb Res. 2010 Apr;125 Suppl 1:S16–S18.
Journal cover image

Published In

Thromb Res

DOI

EISSN

1879-2472

Publication Date

April 2010

Volume

125 Suppl 1

Start / End Page

S16 / S18

Location

United States

Related Subject Headings

  • Thrombin
  • Recombinant Proteins
  • Protein Binding
  • Platelet Activation
  • Phospholipids
  • Models, Biological
  • Lipids
  • Humans
  • Hemostasis
  • Hemophilia A