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The coagulation cascade in cirrhosis.

Publication ,  Journal Article
Monroe, DM; Hoffman, M
Published in: Clin Liver Dis
February 2009

The coagulation "cascade" model accurately represents the mechanisms of the prothrombin time and activated partial thromboplastin time tests. However, these tests and the "cascade" model do not accurately reflect the risk of hemorrhage or thrombosis in vivo. In hepatic insufficiency, a balanced reduction in the levels of most of pro- and anticoagulant proteins produced in the liver does not impair thrombin generation until levels are quite low. However, the ability of the coagulation system to tolerate or recover from an insult is markedly impaired in liver disease. This allows the coagulation system to be more easily tipped into a state favoring either hemorrhage or thrombosis.

Duke Scholars

Published In

Clin Liver Dis

DOI

EISSN

1557-8224

Publication Date

February 2009

Volume

13

Issue

1

Start / End Page

1 / 9

Location

United States

Related Subject Headings

  • Thrombosis
  • Thromboplastin
  • Thrombin
  • Prothrombin Time
  • Models, Biological
  • Liver Failure
  • Liver Cirrhosis
  • Humans
  • Hemostasis
  • Hemorrhage
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Monroe, D. M., & Hoffman, M. (2009). The coagulation cascade in cirrhosis. Clin Liver Dis, 13(1), 1–9. https://doi.org/10.1016/j.cld.2008.09.014
Monroe, Dougald M., and Maureane Hoffman. “The coagulation cascade in cirrhosis.Clin Liver Dis 13, no. 1 (February 2009): 1–9. https://doi.org/10.1016/j.cld.2008.09.014.
Monroe DM, Hoffman M. The coagulation cascade in cirrhosis. Clin Liver Dis. 2009 Feb;13(1):1–9.
Monroe, Dougald M., and Maureane Hoffman. “The coagulation cascade in cirrhosis.Clin Liver Dis, vol. 13, no. 1, Feb. 2009, pp. 1–9. Pubmed, doi:10.1016/j.cld.2008.09.014.
Monroe DM, Hoffman M. The coagulation cascade in cirrhosis. Clin Liver Dis. 2009 Feb;13(1):1–9.
Journal cover image

Published In

Clin Liver Dis

DOI

EISSN

1557-8224

Publication Date

February 2009

Volume

13

Issue

1

Start / End Page

1 / 9

Location

United States

Related Subject Headings

  • Thrombosis
  • Thromboplastin
  • Thrombin
  • Prothrombin Time
  • Models, Biological
  • Liver Failure
  • Liver Cirrhosis
  • Humans
  • Hemostasis
  • Hemorrhage