
Pulmonary vasodilator responses to RP 52891 are mediated by activation of a glibenclamide-sensitive K+ATP channel.
Pulmonary vasodilator responses to the K+ATP channel opener, RP 52891, were investigated in the intact-chest cat under constant flow conditions. When pulmonary vascular tone was increased with U46619, intralobar injections of RP 52891 caused dose-related decreases in lobar arterial and systemic arterial pressures without altering left atrial pressure. RP 52891 was more potent than pinacidil but less potent than cromakalim in dilating the pulmonary vascular bed. Pulmonary vasodilator responses to RP 52891, cromakalim and pinacidil, but not to acetylcholine, nitroprusside or isoproterenol, were blocked by glibenclamide. These data demonstrate that RP 52891 has potent pulmonary vasodilator activity in the cat and suggest that responses are due to opening of a glibenclamide-sensitive K+ATP channel.
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Related Subject Headings
- Vasodilator Agents
- Vasodilation
- Pyrroles
- Pyrans
- Pulmonary Circulation
- Prostaglandin Endoperoxides, Synthetic
- Potassium Channels
- Pinacidil
- Picolines
- Pharmacology & Pharmacy
Citation

Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Vasodilator Agents
- Vasodilation
- Pyrroles
- Pyrans
- Pulmonary Circulation
- Prostaglandin Endoperoxides, Synthetic
- Potassium Channels
- Pinacidil
- Picolines
- Pharmacology & Pharmacy