The effect of toll-like receptors and toll-like receptor genetics in human disease.
Publication
, Journal Article
Garantziotis, S; Hollingsworth, JW; Zaas, AK; Schwartz, DA
Published in: Annu Rev Med
2008
Toll-like receptors (TLRs) enable innate immune recognition of endogenous and exogenous prototypic ligands. They also orchestrate innate and adaptive immune response to infection, inflammation, and tissue injury. Given their significance in the immune response, it is not surprising that genetic variations of TLRs can affect their function and by extension affect the response of the organism to environmental stimuli. The genetics of TLRs provides important insights in gene-environment interactions in health and disease, and it may enable scientists to assess patients' susceptibility to diseases or predict their response to treatments.
Duke Scholars
Published In
Annu Rev Med
DOI
ISSN
0066-4219
Publication Date
2008
Volume
59
Start / End Page
343 / 359
Location
United States
Related Subject Headings
- Toll-Like Receptors
- Signal Transduction
- Polymorphism, Genetic
- Humans
- General & Internal Medicine
- Disease Susceptibility
- 3202 Clinical sciences
- 1103 Clinical Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Garantziotis, S., Hollingsworth, J. W., Zaas, A. K., & Schwartz, D. A. (2008). The effect of toll-like receptors and toll-like receptor genetics in human disease. Annu Rev Med, 59, 343–359. https://doi.org/10.1146/annurev.med.59.061206.112455
Garantziotis, Stavros, John W. Hollingsworth, Aimee K. Zaas, and David A. Schwartz. “The effect of toll-like receptors and toll-like receptor genetics in human disease.” Annu Rev Med 59 (2008): 343–59. https://doi.org/10.1146/annurev.med.59.061206.112455.
Garantziotis S, Hollingsworth JW, Zaas AK, Schwartz DA. The effect of toll-like receptors and toll-like receptor genetics in human disease. Annu Rev Med. 2008;59:343–59.
Garantziotis, Stavros, et al. “The effect of toll-like receptors and toll-like receptor genetics in human disease.” Annu Rev Med, vol. 59, 2008, pp. 343–59. Pubmed, doi:10.1146/annurev.med.59.061206.112455.
Garantziotis S, Hollingsworth JW, Zaas AK, Schwartz DA. The effect of toll-like receptors and toll-like receptor genetics in human disease. Annu Rev Med. 2008;59:343–359.
Published In
Annu Rev Med
DOI
ISSN
0066-4219
Publication Date
2008
Volume
59
Start / End Page
343 / 359
Location
United States
Related Subject Headings
- Toll-Like Receptors
- Signal Transduction
- Polymorphism, Genetic
- Humans
- General & Internal Medicine
- Disease Susceptibility
- 3202 Clinical sciences
- 1103 Clinical Sciences