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Comparison of multiple vaccine vectors in a single heterologous prime-boost trial.

Publication ,  Journal Article
Barefoot, B; Thornburg, NJ; Barouch, DH; Yu, J-S; Sample, C; Johnston, RE; Liao, HX; Kepler, TB; Haynes, BF; Ramsburg, E
Published in: Vaccine
November 11, 2008

The prevention of infectious disease via prophylactic immunization is a mainstay of global public health efforts. Vaccine design would be facilitated by a better understanding of the type and durability of immune responses generated by different vaccine vectors. We report here the results of a comparative immunogenicity trial of six different vaccine vectors expressing the same insert antigen, cowpox virus B5 (CPXV-B5). Of those vectors tested, recombinant adenovirus (rAd5) was the most immunogenic, inducing the highest titer anti-B5 antibodies and conferring protection from sublethal vaccinia virus challenge in mice after a single immunization. We tested select heterologous prime-boost combinations and identified recombinant vesicular stomatitis virus (rVSV) and recombinant Venezuelan equine encephalitis virus replicons (VRP) as the most synergistic regimen. Comparative data such as those presented here are critical to efforts to generate protective vaccines for emerging infectious diseases as well as for biothreat agents.

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Published In

Vaccine

DOI

ISSN

0264-410X

Publication Date

November 11, 2008

Volume

26

Issue

48

Start / End Page

6108 / 6118

Location

Netherlands

Related Subject Headings

  • Virology
  • Vaccinia virus
  • Vaccines, Synthetic
  • Vaccines
  • Plasmids
  • Mycobacterium smegmatis
  • Mice, Inbred C57BL
  • Mice
  • Injections, Intramuscular
  • Immunization, Secondary
 

Citation

APA
Chicago
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Barefoot, B., Thornburg, N. J., Barouch, D. H., Yu, J.-S., Sample, C., Johnston, R. E., … Ramsburg, E. (2008). Comparison of multiple vaccine vectors in a single heterologous prime-boost trial. Vaccine, 26(48), 6108–6118. https://doi.org/10.1016/j.vaccine.2008.09.007
Barefoot, Brice, Natalie J. Thornburg, Daniel H. Barouch, Jae-Sung Yu, Christopher Sample, Robert E. Johnston, Hua Xin Liao, Thomas B. Kepler, Barton F. Haynes, and Elizabeth Ramsburg. “Comparison of multiple vaccine vectors in a single heterologous prime-boost trial.Vaccine 26, no. 48 (November 11, 2008): 6108–18. https://doi.org/10.1016/j.vaccine.2008.09.007.
Barefoot B, Thornburg NJ, Barouch DH, Yu J-S, Sample C, Johnston RE, et al. Comparison of multiple vaccine vectors in a single heterologous prime-boost trial. Vaccine. 2008 Nov 11;26(48):6108–18.
Barefoot, Brice, et al. “Comparison of multiple vaccine vectors in a single heterologous prime-boost trial.Vaccine, vol. 26, no. 48, Nov. 2008, pp. 6108–18. Pubmed, doi:10.1016/j.vaccine.2008.09.007.
Barefoot B, Thornburg NJ, Barouch DH, Yu J-S, Sample C, Johnston RE, Liao HX, Kepler TB, Haynes BF, Ramsburg E. Comparison of multiple vaccine vectors in a single heterologous prime-boost trial. Vaccine. 2008 Nov 11;26(48):6108–6118.
Journal cover image

Published In

Vaccine

DOI

ISSN

0264-410X

Publication Date

November 11, 2008

Volume

26

Issue

48

Start / End Page

6108 / 6118

Location

Netherlands

Related Subject Headings

  • Virology
  • Vaccinia virus
  • Vaccines, Synthetic
  • Vaccines
  • Plasmids
  • Mycobacterium smegmatis
  • Mice, Inbred C57BL
  • Mice
  • Injections, Intramuscular
  • Immunization, Secondary