
A whole-genome association study of major determinants for host control of HIV-1.
Understanding why some people establish and maintain effective control of HIV-1 and others do not is a priority in the effort to develop new treatments for HIV/AIDS. Using a whole-genome association strategy, we identified polymorphisms that explain nearly 15% of the variation among individuals in viral load during the asymptomatic set-point period of infection. One of these is found within an endogenous retroviral element and is associated with major histocompatibility allele human leukocyte antigen (HLA)-B*5701, whereas a second is located near the HLA-C gene. An additional analysis of the time to HIV disease progression implicated two genes, one of which encodes an RNA polymerase I subunit. These findings emphasize the importance of studying human genetic variation as a guide to combating infectious agents.
Duke Scholars
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Related Subject Headings
- Viral Load
- Regression Analysis
- RNA, Untranslated
- RNA, Long Noncoding
- Polymorphism, Single Nucleotide
- Male
- Major Histocompatibility Complex
- Immediate-Early Proteins
- Humans
- Haplotypes
Citation

Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Viral Load
- Regression Analysis
- RNA, Untranslated
- RNA, Long Noncoding
- Polymorphism, Single Nucleotide
- Male
- Major Histocompatibility Complex
- Immediate-Early Proteins
- Humans
- Haplotypes