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Effects of FOXO genotypes on longevity: a biodemographic analysis.

Publication ,  Journal Article
Zeng, Y; Cheng, L; Chen, H; Cao, H; Hauser, ER; Liu, Y; Xiao, Z; Tan, Q; Tian, X-L; Vaupel, JW
Published in: J Gerontol A Biol Sci Med Sci
December 2010

Based on data from 760 centenarians and 1060 middle-age controls (all Han Chinese), this article contributes biodemographic insights and syntheses concerning the magnitude of effects of the FOXO genotypes on longevity. We also estimate independent and joint effects of the genotypes of FOXO1A and FOXO3A genes on long-term survival, considering carrying or not-carrying the minor allele of the single-nucleotide polymorphism of another relevant gene. We found substantial gender differences in the independent effects; positive effects of FOXO3A and negative effects of FOXO1A largely compensate each other if one carries both, although FOXO3A has a stronger impact. Ten-year follow-up cohort analysis shows that at very advanced ages 92-110, adjusted for various confounders, positive effects of FOXO3A on survival remain statistically significant, but no significant effects of FOXO1A alone; G × G interactions between FOXO1A-209 and FOXO3A-310 or FOXO3A-292 decrease survival likelihood by 32%-36% (p < .05); G × E interactions between FOXO1A-209 and regular exercise increase survival likelihood by 31%-32% (p < .05).

Duke Scholars

Published In

J Gerontol A Biol Sci Med Sci

DOI

EISSN

1758-535X

Publication Date

December 2010

Volume

65

Issue

12

Start / End Page

1285 / 1299

Location

United States

Related Subject Headings

  • Survival Analysis
  • Sex Factors
  • Proportional Hazards Models
  • Probability
  • Middle Aged
  • Male
  • Longitudinal Studies
  • Longevity
  • Likelihood Functions
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zeng, Y., Cheng, L., Chen, H., Cao, H., Hauser, E. R., Liu, Y., … Vaupel, J. W. (2010). Effects of FOXO genotypes on longevity: a biodemographic analysis. J Gerontol A Biol Sci Med Sci, 65(12), 1285–1299. https://doi.org/10.1093/gerona/glq156
Zeng, Yi, Lingguo Cheng, Huashuai Chen, Huiqing Cao, Elizabeth R. Hauser, Yuzhi Liu, Zhenyu Xiao, Qihua Tan, Xiao-Li Tian, and James W. Vaupel. “Effects of FOXO genotypes on longevity: a biodemographic analysis.J Gerontol A Biol Sci Med Sci 65, no. 12 (December 2010): 1285–99. https://doi.org/10.1093/gerona/glq156.
Zeng Y, Cheng L, Chen H, Cao H, Hauser ER, Liu Y, et al. Effects of FOXO genotypes on longevity: a biodemographic analysis. J Gerontol A Biol Sci Med Sci. 2010 Dec;65(12):1285–99.
Zeng, Yi, et al. “Effects of FOXO genotypes on longevity: a biodemographic analysis.J Gerontol A Biol Sci Med Sci, vol. 65, no. 12, Dec. 2010, pp. 1285–99. Pubmed, doi:10.1093/gerona/glq156.
Zeng Y, Cheng L, Chen H, Cao H, Hauser ER, Liu Y, Xiao Z, Tan Q, Tian X-L, Vaupel JW. Effects of FOXO genotypes on longevity: a biodemographic analysis. J Gerontol A Biol Sci Med Sci. 2010 Dec;65(12):1285–1299.
Journal cover image

Published In

J Gerontol A Biol Sci Med Sci

DOI

EISSN

1758-535X

Publication Date

December 2010

Volume

65

Issue

12

Start / End Page

1285 / 1299

Location

United States

Related Subject Headings

  • Survival Analysis
  • Sex Factors
  • Proportional Hazards Models
  • Probability
  • Middle Aged
  • Male
  • Longitudinal Studies
  • Longevity
  • Likelihood Functions
  • Humans