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A user's guide to the encyclopedia of DNA elements (ENCODE).

Publication ,  Journal Article
ENCODE Project Consortium,
Published in: PLoS Biol
April 2011

The mission of the Encyclopedia of DNA Elements (ENCODE) Project is to enable the scientific and medical communities to interpret the human genome sequence and apply it to understand human biology and improve health. The ENCODE Consortium is integrating multiple technologies and approaches in a collective effort to discover and define the functional elements encoded in the human genome, including genes, transcripts, and transcriptional regulatory regions, together with their attendant chromatin states and DNA methylation patterns. In the process, standards to ensure high-quality data have been implemented, and novel algorithms have been developed to facilitate analysis. Data and derived results are made available through a freely accessible database. Here we provide an overview of the project and the resources it is generating and illustrate the application of ENCODE data to interpret the human genome.

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Published In

PLoS Biol

DOI

EISSN

1545-7885

Publication Date

April 2011

Volume

9

Issue

4

Start / End Page

e1001046

Location

United States

Related Subject Headings

  • RNA-Binding Proteins
  • RNA, Messenger
  • Quality Control
  • Models, Genetic
  • Internet
  • Humans
  • Genome, Human
  • Gene Expression Regulation
  • Gene Components
  • Developmental Biology
 

Citation

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ENCODE Project Consortium, . (2011). A user's guide to the encyclopedia of DNA elements (ENCODE). PLoS Biol, 9(4), e1001046. https://doi.org/10.1371/journal.pbio.1001046
ENCODE Project Consortium, G. E. “A user's guide to the encyclopedia of DNA elements (ENCODE).PLoS Biol 9, no. 4 (April 2011): e1001046. https://doi.org/10.1371/journal.pbio.1001046.
ENCODE Project Consortium. A user's guide to the encyclopedia of DNA elements (ENCODE). PLoS Biol. 2011 Apr;9(4):e1001046.
ENCODE Project Consortium, G. E. “A user's guide to the encyclopedia of DNA elements (ENCODE).PLoS Biol, vol. 9, no. 4, Apr. 2011, p. e1001046. Pubmed, doi:10.1371/journal.pbio.1001046.
ENCODE Project Consortium. A user's guide to the encyclopedia of DNA elements (ENCODE). PLoS Biol. 2011 Apr;9(4):e1001046.
Journal cover image

Published In

PLoS Biol

DOI

EISSN

1545-7885

Publication Date

April 2011

Volume

9

Issue

4

Start / End Page

e1001046

Location

United States

Related Subject Headings

  • RNA-Binding Proteins
  • RNA, Messenger
  • Quality Control
  • Models, Genetic
  • Internet
  • Humans
  • Genome, Human
  • Gene Expression Regulation
  • Gene Components
  • Developmental Biology