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Modeling the physics of FtsZ assembly and force generation.

Publication ,  Journal Article
Erickson, HP
Published in: Proc Natl Acad Sci U S A
June 9, 2009

The tubulin homolog FtsZ is the major cytoskeletal protein in bacterial cytokinesis. It can generate a constriction force on the bacterial membrane or inside tubular liposomes. Several models have recently been proposed for how this force might be generated. These fall into 2 categories. The first is based on a conformational change from a straight to a curved protofilament. The simplest "hydrolyze and bend" model proposes a 22 degrees bend at every interface containing a GDP. New evidence suggests another curved conformation with a 2.5 degrees bend at every interface and that the relation of curvature to GTP hydrolysis is more complicated than previously thought. However, FtsZ protofilaments do appear to be mechanically rigid enough to bend membranes. A second category of models is based on lateral bonding between protofilaments, postulating that a contraction could be generated when protofilaments slide to increase the number of lateral bonds. Unfortunately these lateral bond models have ignored the contribution of subunit entropy when adding bond energies; if included, the mechanism is seen to be invalid. Finally, I address recent models that try to explain how protofilaments 1-subunit-thick show a cooperative assembly.

Duke Scholars

Published In

Proc Natl Acad Sci U S A

DOI

EISSN

1091-6490

Publication Date

June 9, 2009

Volume

106

Issue

23

Start / End Page

9238 / 9243

Location

United States

Related Subject Headings

  • Tubulin
  • Models, Biological
  • Guanosine Triphosphate
  • Escherichia coli
  • Cytoskeletal Proteins
  • Bacterial Proteins
 

Citation

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Erickson, H. P. (2009). Modeling the physics of FtsZ assembly and force generation. Proc Natl Acad Sci U S A, 106(23), 9238–9243. https://doi.org/10.1073/pnas.0902258106
Erickson, Harold P. “Modeling the physics of FtsZ assembly and force generation.Proc Natl Acad Sci U S A 106, no. 23 (June 9, 2009): 9238–43. https://doi.org/10.1073/pnas.0902258106.
Erickson HP. Modeling the physics of FtsZ assembly and force generation. Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9238–43.
Erickson, Harold P. “Modeling the physics of FtsZ assembly and force generation.Proc Natl Acad Sci U S A, vol. 106, no. 23, June 2009, pp. 9238–43. Pubmed, doi:10.1073/pnas.0902258106.
Erickson HP. Modeling the physics of FtsZ assembly and force generation. Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9238–9243.
Journal cover image

Published In

Proc Natl Acad Sci U S A

DOI

EISSN

1091-6490

Publication Date

June 9, 2009

Volume

106

Issue

23

Start / End Page

9238 / 9243

Location

United States

Related Subject Headings

  • Tubulin
  • Models, Biological
  • Guanosine Triphosphate
  • Escherichia coli
  • Cytoskeletal Proteins
  • Bacterial Proteins