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FtsZ in bacterial cytokinesis: cytoskeleton and force generator all in one.

Publication ,  Journal Article
Erickson, HP; Anderson, DE; Osawa, M
Published in: Microbiol Mol Biol Rev
December 2010

FtsZ, a bacterial homolog of tubulin, is well established as forming the cytoskeletal framework for the cytokinetic ring. Recent work has shown that purified FtsZ, in the absence of any other division proteins, can assemble Z rings when incorporated inside tubular liposomes. Moreover, these artificial Z rings can generate a constriction force, demonstrating that FtsZ is its own force generator. Here we review light microscope observations of how Z rings assemble in bacteria. Assembly begins with long-pitch helices that condense into the Z ring. Once formed, the Z ring can transition to short-pitch helices that are suggestive of its structure. FtsZ assembles in vitro into short protofilaments that are ∼30 subunits long. We present models for how these protofilaments might be further assembled into the Z ring. We discuss recent experiments on assembly dynamics of FtsZ in vitro, with particular attention to how two regulatory proteins, SulA and MinC, inhibit assembly. Recent efforts to develop antibacterial drugs that target FtsZ are reviewed. Finally, we discuss evidence of how FtsZ generates a constriction force: by protofilament bending into a curved conformation.

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Published In

Microbiol Mol Biol Rev

DOI

EISSN

1098-5557

Publication Date

December 2010

Volume

74

Issue

4

Start / End Page

504 / 528

Location

United States

Related Subject Headings

  • Microbiology
  • Cytoskeleton
  • Cytoskeletal Proteins
  • Cytokinesis
  • Bacterial Proteins
  • Bacteria
  • 3107 Microbiology
  • 11 Medical and Health Sciences
  • 10 Technology
  • 06 Biological Sciences
 

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Erickson, H. P., Anderson, D. E., & Osawa, M. (2010). FtsZ in bacterial cytokinesis: cytoskeleton and force generator all in one. Microbiol Mol Biol Rev, 74(4), 504–528. https://doi.org/10.1128/MMBR.00021-10
Erickson, Harold P., David E. Anderson, and Masaki Osawa. “FtsZ in bacterial cytokinesis: cytoskeleton and force generator all in one.Microbiol Mol Biol Rev 74, no. 4 (December 2010): 504–28. https://doi.org/10.1128/MMBR.00021-10.
Erickson HP, Anderson DE, Osawa M. FtsZ in bacterial cytokinesis: cytoskeleton and force generator all in one. Microbiol Mol Biol Rev. 2010 Dec;74(4):504–28.
Erickson, Harold P., et al. “FtsZ in bacterial cytokinesis: cytoskeleton and force generator all in one.Microbiol Mol Biol Rev, vol. 74, no. 4, Dec. 2010, pp. 504–28. Pubmed, doi:10.1128/MMBR.00021-10.
Erickson HP, Anderson DE, Osawa M. FtsZ in bacterial cytokinesis: cytoskeleton and force generator all in one. Microbiol Mol Biol Rev. 2010 Dec;74(4):504–528.

Published In

Microbiol Mol Biol Rev

DOI

EISSN

1098-5557

Publication Date

December 2010

Volume

74

Issue

4

Start / End Page

504 / 528

Location

United States

Related Subject Headings

  • Microbiology
  • Cytoskeleton
  • Cytoskeletal Proteins
  • Cytokinesis
  • Bacterial Proteins
  • Bacteria
  • 3107 Microbiology
  • 11 Medical and Health Sciences
  • 10 Technology
  • 06 Biological Sciences