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Cocaine self-administration reduces excitatory responses in the mouse nucleus accumbens shell.

Publication ,  Journal Article
Schramm-Sapyta, NL; Olsen, CM; Winder, DG
Published in: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
July 2006

Drugs of abuse affect behavior by altering neuronal communication within the brain. Previous research examining the effects of intraperitoneally administered cocaine has revealed that cocaine alters excitatory glutamatergic signaling, both directly through regulation of synaptic function, and indirectly through regulation of cellular excitability in areas of the drug reward circuitry such as the nucleus accumbens (NAcc) and ventral tegmental area. We have now extended these findings by testing the hypothesis that self-administration of cocaine might elicit similar alterations in excitatory signaling in the NAcc shell. We observed that cocaine self-administration reduces synaptically evoked excitatory responses recorded extracellularly in the NAcc shell compared to saline self-administration. This alteration was not accompanied by alterations in paired pulse ratio of synaptically evoked responses or in potentiation of these responses by application of the adenylyl cyclase activator forskolin. This reduction in glutamatergic signaling may be one mechanism by which cocaine exerts its long-term behavioral effects.

Duke Scholars

Published In

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

DOI

EISSN

1740-634X

ISSN

0893-133X

Publication Date

July 2006

Volume

31

Issue

7

Start / End Page

1444 / 1451

Related Subject Headings

  • Time Factors
  • Self Administration
  • Psychiatry
  • Nucleus Accumbens
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Glutamic Acid
  • Excitatory Amino Acid Agonists
  • Evoked Potentials
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Schramm-Sapyta, N. L., Olsen, C. M., & Winder, D. G. (2006). Cocaine self-administration reduces excitatory responses in the mouse nucleus accumbens shell. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 31(7), 1444–1451. https://doi.org/10.1038/sj.npp.1300918
Schramm-Sapyta, Nicole L., Christopher M. Olsen, and Danny G. Winder. “Cocaine self-administration reduces excitatory responses in the mouse nucleus accumbens shell.Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology 31, no. 7 (July 2006): 1444–51. https://doi.org/10.1038/sj.npp.1300918.
Schramm-Sapyta NL, Olsen CM, Winder DG. Cocaine self-administration reduces excitatory responses in the mouse nucleus accumbens shell. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2006 Jul;31(7):1444–51.
Schramm-Sapyta, Nicole L., et al. “Cocaine self-administration reduces excitatory responses in the mouse nucleus accumbens shell.Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, vol. 31, no. 7, July 2006, pp. 1444–51. Epmc, doi:10.1038/sj.npp.1300918.
Schramm-Sapyta NL, Olsen CM, Winder DG. Cocaine self-administration reduces excitatory responses in the mouse nucleus accumbens shell. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2006 Jul;31(7):1444–1451.

Published In

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

DOI

EISSN

1740-634X

ISSN

0893-133X

Publication Date

July 2006

Volume

31

Issue

7

Start / End Page

1444 / 1451

Related Subject Headings

  • Time Factors
  • Self Administration
  • Psychiatry
  • Nucleus Accumbens
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Glutamic Acid
  • Excitatory Amino Acid Agonists
  • Evoked Potentials