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LTP in the mouse nucleus accumbens is developmentally regulated.

Publication ,  Journal Article
Schramm, NL; Egli, RE; Winder, DG
Published in: Synapse (New York, N.Y.)
September 2002

Glutamatergic transmission in the nucleus accumbens (NAc) has been shown to be important for behavioral adaptations in response to drugs of abuse. NMDA-receptor dependent long-term potentiation (LTP) of glutamatergic synaptic transmission has been hypothesized to underlie many lasting alterations in behavior. Thus, we examined LTP in NAc core and find that it is developmentally regulated. Specifically, tetanus-evoked, NMDA receptor-dependent LTP is observed in the NAc of "adolescent" (3-week-old) mice more frequently than in adult (6-20-week-old) mice. In contrast, cAMP-dependent enhancement of transmission is not developmentally regulated. Removal of extracellular Mg(2+) restores LTP in adult NAc core, suggesting developmental regulation of induction processes rather than maintenance mechanisms. These findings are discussed in the context of behavioral changes elicited in response to drugs of abuse, which differ in adolescent vs. adult rodents and humans.

Duke Scholars

Published In

Synapse (New York, N.Y.)

DOI

EISSN

1098-2396

ISSN

0887-4476

Publication Date

September 2002

Volume

45

Issue

4

Start / End Page

213 / 219

Related Subject Headings

  • Synapses
  • Substance-Related Disorders
  • Receptors, N-Methyl-D-Aspartate
  • Organ Culture Techniques
  • Nucleus Accumbens
  • Neurology & Neurosurgery
  • Mice, Inbred C57BL
  • Mice
  • Membrane Potentials
  • Male
 

Citation

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MLA
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Schramm, N. L., Egli, R. E., & Winder, D. G. (2002). LTP in the mouse nucleus accumbens is developmentally regulated. Synapse (New York, N.Y.), 45(4), 213–219. https://doi.org/10.1002/syn.10104
Schramm, Nicole L., Regula E. Egli, and Danny G. Winder. “LTP in the mouse nucleus accumbens is developmentally regulated.Synapse (New York, N.Y.) 45, no. 4 (September 2002): 213–19. https://doi.org/10.1002/syn.10104.
Schramm NL, Egli RE, Winder DG. LTP in the mouse nucleus accumbens is developmentally regulated. Synapse (New York, NY). 2002 Sep;45(4):213–9.
Schramm, Nicole L., et al. “LTP in the mouse nucleus accumbens is developmentally regulated.Synapse (New York, N.Y.), vol. 45, no. 4, Sept. 2002, pp. 213–19. Epmc, doi:10.1002/syn.10104.
Schramm NL, Egli RE, Winder DG. LTP in the mouse nucleus accumbens is developmentally regulated. Synapse (New York, NY). 2002 Sep;45(4):213–219.
Journal cover image

Published In

Synapse (New York, N.Y.)

DOI

EISSN

1098-2396

ISSN

0887-4476

Publication Date

September 2002

Volume

45

Issue

4

Start / End Page

213 / 219

Related Subject Headings

  • Synapses
  • Substance-Related Disorders
  • Receptors, N-Methyl-D-Aspartate
  • Organ Culture Techniques
  • Nucleus Accumbens
  • Neurology & Neurosurgery
  • Mice, Inbred C57BL
  • Mice
  • Membrane Potentials
  • Male