Skip to main content

Emotional learning during dissociative states in borderline personality disorder.

Publication ,  Journal Article
Ebner-Priemer, UW; Mauchnik, J; Kleindienst, N; Schmahl, C; Peper, M; Rosenthal, MZ; Flor, H; Bohus, M
Published in: J Psychiatry Neurosci
May 2009

BACKGROUND: Neurobiological findings and clinical data suggest that dissociative experience inhibits conditioning processes, but experimental studies are lacking. The aim of our study was to determine whether high states of dissociative experience would specifically alter emotional learning, but not declarative knowledge. METHODS: We used an aversive differential delay conditioning procedure in 33 unmedicated patients with borderline personality disorder (BPD) and 35 healthy controls. RESULTS: Patients with BPD who had high state dissociative experiences (BPD D+) showed diminished acquisition of differential aversive delay conditioning with respect to emotional learning compared with those who did not experience dissociative symptoms (BPD D-) and healthy controls (skin conductance response; interaction dissociation x quadratic time x type, p = 0.009). Specifically, the control group and the BPD D- subgroup showed an increase in valence and arousal to the conditioned stimulus (CS+) during the conditioning procedure (all p < 0.012) and demonstrated differential skin conductance responses in the acquisition and extinction phases. In contrast, the BPD D+ subgroup showed no increase in valence and arousal to CS+ or differential response regarding skin conductance. We examined general psychopathology, trauma history, perceptual differences and posttraumatic stress disorder as confounding factors, but we found no evidence of bias. LIMITATIONS: Subdividing the BPD group reduced power. In addition, because our sample included only women, the generalizability of our results is constrained. Furthermore, we performed no separate analysis of the influence of different aspects of dissociation on the learning process. CONCLUSION: Emotional, amygdala-based learning processes seem to be inhibited during state dissociative experience. State dissociative experience may alter acquisition and extinction processes and should be closely monitored in exposure-based psychotherapy.

Duke Scholars

Published In

J Psychiatry Neurosci

EISSN

1488-2434

Publication Date

May 2009

Volume

34

Issue

3

Start / End Page

214 / 222

Location

Canada

Related Subject Headings

  • Surveys and Questionnaires
  • Stress Disorders, Post-Traumatic
  • Psychiatry
  • Psychiatric Status Rating Scales
  • Perception
  • Memory
  • Learning
  • Humans
  • Habituation, Psychophysiologic
  • Galvanic Skin Response
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ebner-Priemer, U. W., Mauchnik, J., Kleindienst, N., Schmahl, C., Peper, M., Rosenthal, M. Z., … Bohus, M. (2009). Emotional learning during dissociative states in borderline personality disorder. J Psychiatry Neurosci, 34(3), 214–222.
Ebner-Priemer, Ulrich W., Jana Mauchnik, Nikolaus Kleindienst, Christian Schmahl, Martin Peper, M Zachary Rosenthal, Herta Flor, and Martin Bohus. “Emotional learning during dissociative states in borderline personality disorder.J Psychiatry Neurosci 34, no. 3 (May 2009): 214–22.
Ebner-Priemer UW, Mauchnik J, Kleindienst N, Schmahl C, Peper M, Rosenthal MZ, et al. Emotional learning during dissociative states in borderline personality disorder. J Psychiatry Neurosci. 2009 May;34(3):214–22.
Ebner-Priemer, Ulrich W., et al. “Emotional learning during dissociative states in borderline personality disorder.J Psychiatry Neurosci, vol. 34, no. 3, May 2009, pp. 214–22.
Ebner-Priemer UW, Mauchnik J, Kleindienst N, Schmahl C, Peper M, Rosenthal MZ, Flor H, Bohus M. Emotional learning during dissociative states in borderline personality disorder. J Psychiatry Neurosci. 2009 May;34(3):214–222.

Published In

J Psychiatry Neurosci

EISSN

1488-2434

Publication Date

May 2009

Volume

34

Issue

3

Start / End Page

214 / 222

Location

Canada

Related Subject Headings

  • Surveys and Questionnaires
  • Stress Disorders, Post-Traumatic
  • Psychiatry
  • Psychiatric Status Rating Scales
  • Perception
  • Memory
  • Learning
  • Humans
  • Habituation, Psychophysiologic
  • Galvanic Skin Response