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Mosaic vaccines elicit CD8+ T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys.

Publication ,  Journal Article
Santra, S; Liao, H-X; Zhang, R; Muldoon, M; Watson, S; Fischer, W; Theiler, J; Szinger, J; Balachandran, H; Buzby, A; Quinn, D; Parks, RJ ...
Published in: Nat Med
March 2010

An effective HIV vaccine must elicit immune responses that recognize genetically diverse viruses. It must generate CD8+ T lymphocytes that control HIV replication and CD4+ T lymphocytes that provide help for the generation and maintenance of both cellular and humoral immune responses against the virus. Creating immunogens that can elicit cellular immune responses against the genetically varied circulating isolates of HIV presents a key challenge for creating an HIV vaccine. Polyvalent mosaic immunogens derived by in silico recombination of natural strains of HIV are designed to induce cellular immune responses that recognize genetically diverse circulating virus isolates. Here we immunized rhesus monkeys by plasmid DNA prime and recombinant vaccinia virus boost with vaccine constructs expressing either consensus or polyvalent mosaic proteins. As compared to consensus immunogens, the mosaic immunogens elicited CD8+ T lymphocyte responses to more epitopes of each viral protein than did the consensus immunogens and to more variant sequences of CD8+ T lymphocyte epitopes. This increased breadth and depth of epitope recognition may contribute both to protection against infection by genetically diverse viruses and to the control of variant viruses that emerge as they mutate away from recognition by cytotoxic T lymphocytes.

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Published In

Nat Med

DOI

EISSN

1546-170X

Publication Date

March 2010

Volume

16

Issue

3

Start / End Page

324 / 328

Location

United States

Related Subject Headings

  • nef Gene Products, Human Immunodeficiency Virus
  • gag Gene Products, Human Immunodeficiency Virus
  • Vaccines, Synthetic
  • Macaca mulatta
  • Lymphocyte Count
  • Lymphocyte Activation
  • Immunology
  • Immunity, Cellular
  • HIV Infections
  • HIV Antigens
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Santra, S., Liao, H.-X., Zhang, R., Muldoon, M., Watson, S., Fischer, W., … Letvin, N. L. (2010). Mosaic vaccines elicit CD8+ T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys. Nat Med, 16(3), 324–328. https://doi.org/10.1038/nm.2108
Santra, Sampa, Hua-Xin Liao, Ruijin Zhang, Mark Muldoon, Sydeaka Watson, Will Fischer, James Theiler, et al. “Mosaic vaccines elicit CD8+ T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys.Nat Med 16, no. 3 (March 2010): 324–28. https://doi.org/10.1038/nm.2108.
Santra S, Liao H-X, Zhang R, Muldoon M, Watson S, Fischer W, et al. Mosaic vaccines elicit CD8+ T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys. Nat Med. 2010 Mar;16(3):324–8.
Santra, Sampa, et al. “Mosaic vaccines elicit CD8+ T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys.Nat Med, vol. 16, no. 3, Mar. 2010, pp. 324–28. Pubmed, doi:10.1038/nm.2108.
Santra S, Liao H-X, Zhang R, Muldoon M, Watson S, Fischer W, Theiler J, Szinger J, Balachandran H, Buzby A, Quinn D, Parks RJ, Tsao C-Y, Carville A, Mansfield KG, Pavlakis GN, Felber BK, Haynes BF, Korber BT, Letvin NL. Mosaic vaccines elicit CD8+ T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys. Nat Med. 2010 Mar;16(3):324–328.

Published In

Nat Med

DOI

EISSN

1546-170X

Publication Date

March 2010

Volume

16

Issue

3

Start / End Page

324 / 328

Location

United States

Related Subject Headings

  • nef Gene Products, Human Immunodeficiency Virus
  • gag Gene Products, Human Immunodeficiency Virus
  • Vaccines, Synthetic
  • Macaca mulatta
  • Lymphocyte Count
  • Lymphocyte Activation
  • Immunology
  • Immunity, Cellular
  • HIV Infections
  • HIV Antigens