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Intra subject variation and correlation of motor potentials evoked by transcranial magnetic stimulation.

Publication ,  Journal Article
Roy Choudhury, K; Boyle, L; Burke, M; Lombard, W; Ryan, S; McNamara, B
Published in: Ir J Med Sci
December 2011

BACKGROUND: Characterising intra and inter-subject variability of motor-evoked potential (MEP) measurements from transcranial magnetic stimulation (TMS) is key to its development as a diagnostic tool. METHODS: We performed three experiments to elucidate MEP variability within subjects: (i) repeated measurements at different levels of stimulation and muscle activation, (ii) simultaneous measurements at pairs of ipsilateral and contralateral muscles, (iii) simultaneous measurements of contralateral muscles when one is activated. RESULTS: Cube root transformation of MEP data produces approximately constant coefficient of variation with Gaussian distribution and no significant autocorrelation between repeat measurements. After adjustment of intersubject variability, correlation between simultaneous muscle pairs was insignificant (p = 0.36). Highly significant effects were observed due to increase in intensity of stimulation: (0.07, 0.23) mV, p < 0.0001, muscle type: (p < 0.009) and activation of ipsilateral muscle: (0.10, 0.49) mV, p < 0.0001. CONCLUSION: Corticospinal effect is dominated by intersubject variability in simultaneous measurements on normal population.

Duke Scholars

Published In

Ir J Med Sci

DOI

EISSN

1863-4362

Publication Date

December 2011

Volume

180

Issue

4

Start / End Page

873 / 880

Location

Ireland

Related Subject Headings

  • Young Adult
  • Transcranial Magnetic Stimulation
  • Pyramidal Tracts
  • Muscle, Skeletal
  • Humans
  • General & Internal Medicine
  • Evoked Potentials, Motor
  • Electromyography
  • Analysis of Variance
  • Adult
 

Citation

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Roy Choudhury, K., Boyle, L., Burke, M., Lombard, W., Ryan, S., & McNamara, B. (2011). Intra subject variation and correlation of motor potentials evoked by transcranial magnetic stimulation. Ir J Med Sci, 180(4), 873–880. https://doi.org/10.1007/s11845-011-0722-4
Roy Choudhury, K., L. Boyle, M. Burke, W. Lombard, S. Ryan, and B. McNamara. “Intra subject variation and correlation of motor potentials evoked by transcranial magnetic stimulation.Ir J Med Sci 180, no. 4 (December 2011): 873–80. https://doi.org/10.1007/s11845-011-0722-4.
Roy Choudhury K, Boyle L, Burke M, Lombard W, Ryan S, McNamara B. Intra subject variation and correlation of motor potentials evoked by transcranial magnetic stimulation. Ir J Med Sci. 2011 Dec;180(4):873–80.
Roy Choudhury, K., et al. “Intra subject variation and correlation of motor potentials evoked by transcranial magnetic stimulation.Ir J Med Sci, vol. 180, no. 4, Dec. 2011, pp. 873–80. Pubmed, doi:10.1007/s11845-011-0722-4.
Roy Choudhury K, Boyle L, Burke M, Lombard W, Ryan S, McNamara B. Intra subject variation and correlation of motor potentials evoked by transcranial magnetic stimulation. Ir J Med Sci. 2011 Dec;180(4):873–880.
Journal cover image

Published In

Ir J Med Sci

DOI

EISSN

1863-4362

Publication Date

December 2011

Volume

180

Issue

4

Start / End Page

873 / 880

Location

Ireland

Related Subject Headings

  • Young Adult
  • Transcranial Magnetic Stimulation
  • Pyramidal Tracts
  • Muscle, Skeletal
  • Humans
  • General & Internal Medicine
  • Evoked Potentials, Motor
  • Electromyography
  • Analysis of Variance
  • Adult