Antinuclear antibodies in healthy people: the tip of autoimmunity's iceberg?
Publication
, Journal Article
Pisetsky, DS
Published in: Arthritis Res Ther
April 21, 2011
Antinuclear antibodies (ANAs) are venerable biomarkers for assessing the diagnosis and prognosis of patients with autoimmunity. While closely associated with diseases such as systemic lupus erythematosus, ANA expression occurs commonly in healthy people. The basis for this expression is unknown, although it may reflect features of the assays for antibody detection or intrinsic immunological disturbances in otherwise normal individuals. Like autoimmunity itself, ANA expression is more common among women than men, pointing to an important determinant of these responses. Future research will clarify the mechanisms of ANA expression and the utility of current assays as antecedent and screening biomarkers.
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Published In
Arthritis Res Ther
DOI
EISSN
1478-6362
Publication Date
April 21, 2011
Volume
13
Issue
2
Start / End Page
109
Location
England
Related Subject Headings
- Male
- Lupus Erythematosus, Systemic
- Humans
- Gene Expression Profiling
- Female
- Arthritis & Rheumatology
- Antibodies, Antinuclear
- 3204 Immunology
- 3202 Clinical sciences
- 1117 Public Health and Health Services
Citation
APA
Chicago
ICMJE
MLA
NLM
Pisetsky, D. S. (2011). Antinuclear antibodies in healthy people: the tip of autoimmunity's iceberg? Arthritis Res Ther, 13(2), 109. https://doi.org/10.1186/ar3282
Pisetsky, David S. “Antinuclear antibodies in healthy people: the tip of autoimmunity's iceberg?” Arthritis Res Ther 13, no. 2 (April 21, 2011): 109. https://doi.org/10.1186/ar3282.
Pisetsky DS. Antinuclear antibodies in healthy people: the tip of autoimmunity's iceberg? Arthritis Res Ther. 2011 Apr 21;13(2):109.
Pisetsky, David S. “Antinuclear antibodies in healthy people: the tip of autoimmunity's iceberg?” Arthritis Res Ther, vol. 13, no. 2, Apr. 2011, p. 109. Pubmed, doi:10.1186/ar3282.
Pisetsky DS. Antinuclear antibodies in healthy people: the tip of autoimmunity's iceberg? Arthritis Res Ther. 2011 Apr 21;13(2):109.
Published In
Arthritis Res Ther
DOI
EISSN
1478-6362
Publication Date
April 21, 2011
Volume
13
Issue
2
Start / End Page
109
Location
England
Related Subject Headings
- Male
- Lupus Erythematosus, Systemic
- Humans
- Gene Expression Profiling
- Female
- Arthritis & Rheumatology
- Antibodies, Antinuclear
- 3204 Immunology
- 3202 Clinical sciences
- 1117 Public Health and Health Services