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The role of adhesion molecules in epithelial-T-cell interactions in thymus and skin.

Publication ,  Journal Article
Singer, KH; Le, PT; Denning, SM; Whichard, LP; Haynes, BF
Published in: J Invest Dermatol
June 1990

Interaction of T lymphocytes with other cell types is important for normal T-cell development and function. Recently, a number of adhesion molecules important in T-cell interactions with other cell types have been defined. In this paper we review the role of two adhesion pathways, CD2/LFA-3 and LFA-1/ICAM-1, in T-cell interactions with epithelial cells of the thymus and skin. While thymic epithelium-T-cell interactions were mediated by both the LFA-1/ICAM-1 pathway and the CD2/LFA-3 pathway, epidermal-T-cell interactions were mediated primarily by the LFA-1/ICAM-1 pathway. Although ICAM-1 was not expressed in vivo on epidermal keratinocytes in normal skin, ICAM-1 was expressed by epidermal keratinocytes at the site of T-cell infiltration in inflammatory dermatitis. ICAM-1 was expressed in vivo on thymic epithelium. Both LFA-3 and ICAM-1 were expressed on epithelial cells of thymus and skin early on in fetal ontogeny. These antigen-independent adhesion molecules play an important role in the cell-cell interactions associated with T-cell differentiation and function.

Duke Scholars

Published In

J Invest Dermatol

DOI

ISSN

0022-202X

Publication Date

June 1990

Volume

94

Issue

6 Suppl

Start / End Page

85S / 90S

Location

United States

Related Subject Headings

  • Thymus Gland
  • T-Lymphocytes
  • Skin
  • Receptors, Leukocyte-Adhesion
  • Membrane Glycoproteins
  • Major Histocompatibility Complex
  • Lymphocyte Function-Associated Antigen-1
  • Humans
  • Epithelial Cells
  • Epidermis
 

Citation

APA
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ICMJE
MLA
NLM
Singer, K. H., Le, P. T., Denning, S. M., Whichard, L. P., & Haynes, B. F. (1990). The role of adhesion molecules in epithelial-T-cell interactions in thymus and skin. J Invest Dermatol, 94(6 Suppl), 85S-90S. https://doi.org/10.1111/1523-1747.ep12876038
Singer, K. H., P. T. Le, S. M. Denning, L. P. Whichard, and B. F. Haynes. “The role of adhesion molecules in epithelial-T-cell interactions in thymus and skin.J Invest Dermatol 94, no. 6 Suppl (June 1990): 85S-90S. https://doi.org/10.1111/1523-1747.ep12876038.
Singer KH, Le PT, Denning SM, Whichard LP, Haynes BF. The role of adhesion molecules in epithelial-T-cell interactions in thymus and skin. J Invest Dermatol. 1990 Jun;94(6 Suppl):85S-90S.
Singer, K. H., et al. “The role of adhesion molecules in epithelial-T-cell interactions in thymus and skin.J Invest Dermatol, vol. 94, no. 6 Suppl, June 1990, pp. 85S-90S. Pubmed, doi:10.1111/1523-1747.ep12876038.
Singer KH, Le PT, Denning SM, Whichard LP, Haynes BF. The role of adhesion molecules in epithelial-T-cell interactions in thymus and skin. J Invest Dermatol. 1990 Jun;94(6 Suppl):85S-90S.

Published In

J Invest Dermatol

DOI

ISSN

0022-202X

Publication Date

June 1990

Volume

94

Issue

6 Suppl

Start / End Page

85S / 90S

Location

United States

Related Subject Headings

  • Thymus Gland
  • T-Lymphocytes
  • Skin
  • Receptors, Leukocyte-Adhesion
  • Membrane Glycoproteins
  • Major Histocompatibility Complex
  • Lymphocyte Function-Associated Antigen-1
  • Humans
  • Epithelial Cells
  • Epidermis