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Characterization of thymus-derived lymphocyte subsets in acute Epstein-Barr virus-induced infectious mononucleosis.

Publication ,  Journal Article
Haynes, BF; Schooley, RT; Grouse, JE; Payling-Wright, CR; Dolin, R; Fauci, AS
Published in: J Immunol
February 1979

Changes in thymus-derived (T) lymphocyte subpopulation numbers were studied in patients with acute and convalescent Epstein-Barr virus (EBV)-induced infectious mononucleosis (LM). T cell subsets were characterized by the presence of Fc receptors for IgG (TG), for IgM (TM) or by the absence of either receptor (Tnon-M, non-G). We found that in acute IM, total numbers of T and B lymphocytes were elevated (p less than 0.01). Of the T lymphocyte subsets, the total number of Tnon-M, non-G lymphocytes was increased six fold compared to normal subjects (p less than 0.001) and included the majority of the atypical T lymphocytes. The number of total TG and TM lymphocytes was moderately increased (p less than 0.05). In convalescent IM patients, the number of total T cells remained slightly elevated (p less than 0.02) whereas proportions and absolute numbers of B lymphocytes and T cell subsets returned to near normal levels. Thus, acute Epstein-Barr virus-induced IM is associated with a T lymphocytosis which is composed predominantly of atypical T cells which lack detectable Fc receptors for IgG or IgM.

Duke Scholars

Published In

J Immunol

ISSN

0022-1767

Publication Date

February 1979

Volume

122

Issue

2

Start / End Page

699 / 702

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Infectious Mononucleosis
  • Immunology
  • Immunoglobulin M
  • Immunoglobulin G
  • Humans
  • Herpesvirus 4, Human
  • Cell Separation
  • Adult
  • Acute Disease
 

Citation

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MLA
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Haynes, B. F., Schooley, R. T., Grouse, J. E., Payling-Wright, C. R., Dolin, R., & Fauci, A. S. (1979). Characterization of thymus-derived lymphocyte subsets in acute Epstein-Barr virus-induced infectious mononucleosis. J Immunol, 122(2), 699–702.
Haynes, B. F., R. T. Schooley, J. E. Grouse, C. R. Payling-Wright, R. Dolin, and A. S. Fauci. “Characterization of thymus-derived lymphocyte subsets in acute Epstein-Barr virus-induced infectious mononucleosis.J Immunol 122, no. 2 (February 1979): 699–702.
Haynes BF, Schooley RT, Grouse JE, Payling-Wright CR, Dolin R, Fauci AS. Characterization of thymus-derived lymphocyte subsets in acute Epstein-Barr virus-induced infectious mononucleosis. J Immunol. 1979 Feb;122(2):699–702.
Haynes, B. F., et al. “Characterization of thymus-derived lymphocyte subsets in acute Epstein-Barr virus-induced infectious mononucleosis.J Immunol, vol. 122, no. 2, Feb. 1979, pp. 699–702.
Haynes BF, Schooley RT, Grouse JE, Payling-Wright CR, Dolin R, Fauci AS. Characterization of thymus-derived lymphocyte subsets in acute Epstein-Barr virus-induced infectious mononucleosis. J Immunol. 1979 Feb;122(2):699–702.

Published In

J Immunol

ISSN

0022-1767

Publication Date

February 1979

Volume

122

Issue

2

Start / End Page

699 / 702

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Infectious Mononucleosis
  • Immunology
  • Immunoglobulin M
  • Immunoglobulin G
  • Humans
  • Herpesvirus 4, Human
  • Cell Separation
  • Adult
  • Acute Disease