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Wegener's granulomatosis: prospective clinical and therapeutic experience with 85 patients for 21 years.

Publication ,  Journal Article
Fauci, AS; Haynes, BF; Katz, P; Wolff, SM
Published in: Ann Intern Med
January 1983

Eighty-five patients with Wegener's granulomatosis were studied for 21 years at the National Institutes of Health. Patients were treated with a protocol consisting of cyclophosphamide, 2 mg/kg body weight d, together with prednisone, 1 mg/kg body weight d, followed by conversion of the prednisone to an alternate-day regimen. Complete remissions were achieved in 79 of 85 patients (93%). The mean duration of remission for living patients was 48.2 (+/- 3.6) months. Twenty-three patients are off all therapy for a mean duration of 35.3 (+/- 6.3) months without therapy. This study provides a prospective experience with Wegener's granulomatosis and shows that long-term remissions can be induced and maintained in an extremely high number of patients by the combination of daily cyclophosphamide and alternate-day prednisone therapy.

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Published In

Ann Intern Med

DOI

ISSN

0003-4819

Publication Date

January 1983

Volume

98

Issue

1

Start / End Page

76 / 85

Location

United States

Related Subject Headings

  • Skin Diseases
  • Respiratory Tract Diseases
  • Prospective Studies
  • Prednisone
  • Nervous System Diseases
  • Muscular Diseases
  • Middle Aged
  • Male
  • Lung Diseases
  • Kidney Diseases
 

Citation

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Fauci, A. S., Haynes, B. F., Katz, P., & Wolff, S. M. (1983). Wegener's granulomatosis: prospective clinical and therapeutic experience with 85 patients for 21 years. Ann Intern Med, 98(1), 76–85. https://doi.org/10.7326/0003-4819-98-1-76
Fauci, A. S., B. F. Haynes, P. Katz, and S. M. Wolff. “Wegener's granulomatosis: prospective clinical and therapeutic experience with 85 patients for 21 years.Ann Intern Med 98, no. 1 (January 1983): 76–85. https://doi.org/10.7326/0003-4819-98-1-76.
Fauci AS, Haynes BF, Katz P, Wolff SM. Wegener's granulomatosis: prospective clinical and therapeutic experience with 85 patients for 21 years. Ann Intern Med. 1983 Jan;98(1):76–85.
Fauci, A. S., et al. “Wegener's granulomatosis: prospective clinical and therapeutic experience with 85 patients for 21 years.Ann Intern Med, vol. 98, no. 1, Jan. 1983, pp. 76–85. Pubmed, doi:10.7326/0003-4819-98-1-76.
Fauci AS, Haynes BF, Katz P, Wolff SM. Wegener's granulomatosis: prospective clinical and therapeutic experience with 85 patients for 21 years. Ann Intern Med. 1983 Jan;98(1):76–85.

Published In

Ann Intern Med

DOI

ISSN

0003-4819

Publication Date

January 1983

Volume

98

Issue

1

Start / End Page

76 / 85

Location

United States

Related Subject Headings

  • Skin Diseases
  • Respiratory Tract Diseases
  • Prospective Studies
  • Prednisone
  • Nervous System Diseases
  • Muscular Diseases
  • Middle Aged
  • Male
  • Lung Diseases
  • Kidney Diseases