Phenotypic characterization of human cytolytic T lymphocytes in mixed lymphocyte culture.
Publication
, Journal Article
Moretta, A; Mingari, MC; Haynes, BF; Sekaly, RP; Moretta, L; Fauci, AS
Published in: J Exp Med
January 1, 1981
Mixed lymphocyte reaction (MLR)-activated T cells were analyzed according to the expression of various cell surface markers by the specific cytotoxic T lymphocytes (CTL) generated in the MLR. CTL were found exclusively in a population of MLR-activated T cells that lacked detectable Fc gamma R but that expressed a surface antigen recognized by the 4F2 monoclonal antibody. In contrast, CTL were found in both the Ia-positive and Ia-negative cells after MLR activation. Thus, the specific CTL generated in the allogeneic MLR can be identified and isolated by virtue of the expression of a particular cell surface marker.
Duke Scholars
Published In
J Exp Med
DOI
ISSN
0022-1007
Publication Date
January 1, 1981
Volume
153
Issue
1
Start / End Page
213 / 218
Location
United States
Related Subject Headings
- T-Lymphocytes
- Receptors, Fc
- Phenotype
- Lymphocyte Culture Test, Mixed
- Immunology
- Immunity, Cellular
- Humans
- Histocompatibility Antigens Class II
- Cytotoxicity, Immunologic
- Antigens, Surface
Citation
APA
Chicago
ICMJE
MLA
NLM
Moretta, A., Mingari, M. C., Haynes, B. F., Sekaly, R. P., Moretta, L., & Fauci, A. S. (1981). Phenotypic characterization of human cytolytic T lymphocytes in mixed lymphocyte culture. J Exp Med, 153(1), 213–218. https://doi.org/10.1084/jem.153.1.213
Moretta, A., M. C. Mingari, B. F. Haynes, R. P. Sekaly, L. Moretta, and A. S. Fauci. “Phenotypic characterization of human cytolytic T lymphocytes in mixed lymphocyte culture.” J Exp Med 153, no. 1 (January 1, 1981): 213–18. https://doi.org/10.1084/jem.153.1.213.
Moretta A, Mingari MC, Haynes BF, Sekaly RP, Moretta L, Fauci AS. Phenotypic characterization of human cytolytic T lymphocytes in mixed lymphocyte culture. J Exp Med. 1981 Jan 1;153(1):213–8.
Moretta, A., et al. “Phenotypic characterization of human cytolytic T lymphocytes in mixed lymphocyte culture.” J Exp Med, vol. 153, no. 1, Jan. 1981, pp. 213–18. Pubmed, doi:10.1084/jem.153.1.213.
Moretta A, Mingari MC, Haynes BF, Sekaly RP, Moretta L, Fauci AS. Phenotypic characterization of human cytolytic T lymphocytes in mixed lymphocyte culture. J Exp Med. 1981 Jan 1;153(1):213–218.
Published In
J Exp Med
DOI
ISSN
0022-1007
Publication Date
January 1, 1981
Volume
153
Issue
1
Start / End Page
213 / 218
Location
United States
Related Subject Headings
- T-Lymphocytes
- Receptors, Fc
- Phenotype
- Lymphocyte Culture Test, Mixed
- Immunology
- Immunity, Cellular
- Humans
- Histocompatibility Antigens Class II
- Cytotoxicity, Immunologic
- Antigens, Surface