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Different patterns of immune responses but similar control of a simian-human immunodeficiency virus 89.6P mucosal challenge by modified vaccinia virus Ankara (MVA) and DNA/MVA vaccines.

Publication ,  Journal Article
Amara, RR; Villinger, F; Staprans, SI; Altman, JD; Montefiori, DC; Kozyr, NL; Xu, Y; Wyatt, LS; Earl, PL; Herndon, JG; McClure, HM; Moss, B ...
Published in: J Virol
August 2002

Recently we demonstrated the control of a mucosal challenge with a pathogenic chimera of simian and human immunodeficiency virus (SHIV-89.6P) by priming with a Gag-Pol-Env-expressing DNA and boosting with a Gag-Pol-Env-expressing recombinant modified vaccinia virus Ankara (DNA/MVA) vaccine. Here we evaluate the ability of the MVA component of this vaccine to serve as both a prime and a boost for an AIDS vaccine. The same immunization schedule, MVA dose, and challenge conditions were used as in the prior DNA/MVA vaccine trial. Compared to the DNA/MVA vaccine, the MVA-only vaccine raised less than 1/10 the number of vaccine-specific T cells but 10-fold-higher titers of binding antibody for Env. Postchallenge, the animals vaccinated with MVA alone increased their CD8 cell numbers to levels that were similar to those seen in DNA/MVA-vaccinated animals. However, they underwent a slower emergence and contraction of antiviral CD8 T cells and were slower to generate neutralizing antibodies than the DNA/MVA-vaccinated animals. Despite this, by 5 weeks postchallenge, the MVA-only-vaccinated animals had achieved as good control of the viral infection as the DNA/MVA group, a situation that has held up to the present time in the trial (48 weeks postchallenge). Thus, MVA vaccines, as well as DNA/MVA vaccines, merit further evaluation for their ability to control the current AIDS pandemic.

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Published In

J Virol

DOI

ISSN

0022-538X

Publication Date

August 2002

Volume

76

Issue

15

Start / End Page

7625 / 7631

Location

United States

Related Subject Headings

  • Virology
  • Vaccinia virus
  • Vaccines, DNA
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • RNA, Viral
  • Macaca mulatta
  • Humans
  • HIV Infections
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Amara, R. R., Villinger, F., Staprans, S. I., Altman, J. D., Montefiori, D. C., Kozyr, N. L., … Robinson, H. L. (2002). Different patterns of immune responses but similar control of a simian-human immunodeficiency virus 89.6P mucosal challenge by modified vaccinia virus Ankara (MVA) and DNA/MVA vaccines. J Virol, 76(15), 7625–7631. https://doi.org/10.1128/jvi.76.15.7625-7631.2002
Amara, Rama Rao, Francois Villinger, Silvija I. Staprans, John D. Altman, David C. Montefiori, Natalia L. Kozyr, Yan Xu, et al. “Different patterns of immune responses but similar control of a simian-human immunodeficiency virus 89.6P mucosal challenge by modified vaccinia virus Ankara (MVA) and DNA/MVA vaccines.J Virol 76, no. 15 (August 2002): 7625–31. https://doi.org/10.1128/jvi.76.15.7625-7631.2002.
Amara, Rama Rao, et al. “Different patterns of immune responses but similar control of a simian-human immunodeficiency virus 89.6P mucosal challenge by modified vaccinia virus Ankara (MVA) and DNA/MVA vaccines.J Virol, vol. 76, no. 15, Aug. 2002, pp. 7625–31. Pubmed, doi:10.1128/jvi.76.15.7625-7631.2002.
Amara RR, Villinger F, Staprans SI, Altman JD, Montefiori DC, Kozyr NL, Xu Y, Wyatt LS, Earl PL, Herndon JG, McClure HM, Moss B, Robinson HL. Different patterns of immune responses but similar control of a simian-human immunodeficiency virus 89.6P mucosal challenge by modified vaccinia virus Ankara (MVA) and DNA/MVA vaccines. J Virol. 2002 Aug;76(15):7625–7631.

Published In

J Virol

DOI

ISSN

0022-538X

Publication Date

August 2002

Volume

76

Issue

15

Start / End Page

7625 / 7631

Location

United States

Related Subject Headings

  • Virology
  • Vaccinia virus
  • Vaccines, DNA
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • RNA, Viral
  • Macaca mulatta
  • Humans
  • HIV Infections