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Suppression of adaptive immune responses during primary SIV infection of sabaeus African green monkeys delays partial containment of viremia but does not induce disease.

Publication ,  Journal Article
Zahn, RC; Rett, MD; Li, M; Tang, H; Korioth-Schmitz, B; Balachandran, H; White, R; Pryputniewicz, S; Letvin, NL; Kaur, A; Montefiori, DC ...
Published in: Blood
April 15, 2010

One of the most puzzling observations in HIV research is the lack of pathogenicity in most nonhuman primate species that are natural hosts of simian immunodeficiency virus (SIV) infection. Despite this, natural hosts experience a level of viremia similar to humans infected with HIV or macaques infected with SIV. To determine the role of adaptive immune responses in viral containment and lack of disease, we delayed the generation of cellular and humoral immune responses by administering anti-CD8- and anti-CD20 lymphocyte-depleting antibodies to sabaeus African green monkeys (Chlorocebus sabaeus) before challenge with SIV(sab9315BR). In vivo lymphocyte depletion during primary infection resulted in a brief elevation of viremia but not in disease. Based on the magnitude and timing of SIV-specific CD8(+) T-cell responses in the lymphocyte-depleted animals, CD8(+) T-cell responses appear to contribute to viral containment in natural hosts. We found no evidence for a contribution of humoral immune responses in viral containment. These studies indicate that natural hosts have developed mechanisms in addition to classic adaptive immune responses to cope with this lentiviral infection. Thus, adaptive immune responses in natural hosts appear to be less critical for viral containment than in HIV infection.

Duke Scholars

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Published In

Blood

DOI

EISSN

1528-0020

Publication Date

April 15, 2010

Volume

115

Issue

15

Start / End Page

3070 / 3078

Location

United States

Related Subject Headings

  • Viremia
  • Time Factors
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • Rituximab
  • Lymphoid Tissue
  • Lymphocyte Depletion
  • Ki-67 Antigen
  • Interferon-gamma
 

Citation

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Zahn, R. C., Rett, M. D., Li, M., Tang, H., Korioth-Schmitz, B., Balachandran, H., … Schmitz, J. E. (2010). Suppression of adaptive immune responses during primary SIV infection of sabaeus African green monkeys delays partial containment of viremia but does not induce disease. Blood, 115(15), 3070–3078. https://doi.org/10.1182/blood-2009-10-245225
Zahn, Roland C., Melisa D. Rett, Ming Li, Haili Tang, Birgit Korioth-Schmitz, Harikrishnan Balachandran, Robert White, et al. “Suppression of adaptive immune responses during primary SIV infection of sabaeus African green monkeys delays partial containment of viremia but does not induce disease.Blood 115, no. 15 (April 15, 2010): 3070–78. https://doi.org/10.1182/blood-2009-10-245225.
Zahn, Roland C., et al. “Suppression of adaptive immune responses during primary SIV infection of sabaeus African green monkeys delays partial containment of viremia but does not induce disease.Blood, vol. 115, no. 15, Apr. 2010, pp. 3070–78. Pubmed, doi:10.1182/blood-2009-10-245225.
Zahn RC, Rett MD, Li M, Tang H, Korioth-Schmitz B, Balachandran H, White R, Pryputniewicz S, Letvin NL, Kaur A, Montefiori DC, Carville A, Hirsch VM, Allan JS, Schmitz JE. Suppression of adaptive immune responses during primary SIV infection of sabaeus African green monkeys delays partial containment of viremia but does not induce disease. Blood. 2010 Apr 15;115(15):3070–3078.

Published In

Blood

DOI

EISSN

1528-0020

Publication Date

April 15, 2010

Volume

115

Issue

15

Start / End Page

3070 / 3078

Location

United States

Related Subject Headings

  • Viremia
  • Time Factors
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • Rituximab
  • Lymphoid Tissue
  • Lymphocyte Depletion
  • Ki-67 Antigen
  • Interferon-gamma