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The association between radiographic response and overall survival in men with metastatic castration-resistant prostate cancer receiving chemotherapy.

Publication ,  Journal Article
Sonpavde, G; Pond, GR; Berry, WR; de Wit, R; Eisenberger, MA; Tannock, IF; Armstrong, AJ
Published in: Cancer
September 1, 2011

BACKGROUND: In men with metastatic castration-resistant prostate cancer (CRPC), the association of measurable tumor responses with overall survival (OS) is unknown. The authors retrospectively evaluated the TAX327 phase 3 trial to study this relation. METHODS: Eligible patients for this analysis included those with World Health Organization (WHO)-defined measurable metastatic disease randomized to receive either docetaxel or mitoxantrone. OS was estimated by using the Kaplan-Meier method, and the prognostic relation of WHO-defined radiologic response with OS was performed by using Cox proportional hazards regression. Landmark analyses evaluated survival from baseline and at 2, 3, 4, and 6 months after baseline. RESULTS: Four hundred twelve patients enrolled on the TAX327 trial had measurable tumors. Thirty-seven patients exhibited a complete or partial objective response (CR/PR, 9.0%), 116 had stable disease (SD, 28.2%), 99 had progressive disease (PD, 24%) and 160 (38.8%) did not have a after-baseline objective assessment. Partial responders demonstrated longer median OS (29.0 months) than patients with SD (22.1 months) or those with PD (10.8 months) or those who were not assessed (12.7 months). These results remained after landmark analysis. The authors found a significant association between ≥ 30% prostate-specific antigen (PSA) declines and radiologic response, with ≥ 30% PSA declines occurring in all patients with CR/PR, 79.8% of patients with SD, and 34.4% with PD. Radiologic response remained a significant but modest post-treatment prognostic factor for OS after adjusting for treatment, pain response, and ≥ 30% PSA decline (P = .009). CONCLUSIONS: In men with metastatic CRPC and measurable disease receiving chemotherapy, objective tumor response was prognostic for OS and appeared to complement PSA assessment.

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Published In

Cancer

DOI

EISSN

1097-0142

Publication Date

September 1, 2011

Volume

117

Issue

17

Start / End Page

3963 / 3971

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Treatment Failure
  • Randomized Controlled Trials as Topic
  • Radiography
  • Prostatic Neoplasms
  • Prostate-Specific Antigen
  • Prognosis
  • Oncology & Carcinogenesis
  • Neoplasm Metastasis
  • Middle Aged
 

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Sonpavde, G., Pond, G. R., Berry, W. R., de Wit, R., Eisenberger, M. A., Tannock, I. F., & Armstrong, A. J. (2011). The association between radiographic response and overall survival in men with metastatic castration-resistant prostate cancer receiving chemotherapy. Cancer, 117(17), 3963–3971. https://doi.org/10.1002/cncr.25982
Sonpavde, Guru, Gregory R. Pond, William R. Berry, Ronald de Wit, Mario A. Eisenberger, Ian F. Tannock, and Andrew J. Armstrong. “The association between radiographic response and overall survival in men with metastatic castration-resistant prostate cancer receiving chemotherapy.Cancer 117, no. 17 (September 1, 2011): 3963–71. https://doi.org/10.1002/cncr.25982.
Sonpavde G, Pond GR, Berry WR, de Wit R, Eisenberger MA, Tannock IF, et al. The association between radiographic response and overall survival in men with metastatic castration-resistant prostate cancer receiving chemotherapy. Cancer. 2011 Sep 1;117(17):3963–71.
Sonpavde, Guru, et al. “The association between radiographic response and overall survival in men with metastatic castration-resistant prostate cancer receiving chemotherapy.Cancer, vol. 117, no. 17, Sept. 2011, pp. 3963–71. Pubmed, doi:10.1002/cncr.25982.
Sonpavde G, Pond GR, Berry WR, de Wit R, Eisenberger MA, Tannock IF, Armstrong AJ. The association between radiographic response and overall survival in men with metastatic castration-resistant prostate cancer receiving chemotherapy. Cancer. 2011 Sep 1;117(17):3963–3971.
Journal cover image

Published In

Cancer

DOI

EISSN

1097-0142

Publication Date

September 1, 2011

Volume

117

Issue

17

Start / End Page

3963 / 3971

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Treatment Failure
  • Randomized Controlled Trials as Topic
  • Radiography
  • Prostatic Neoplasms
  • Prostate-Specific Antigen
  • Prognosis
  • Oncology & Carcinogenesis
  • Neoplasm Metastasis
  • Middle Aged