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Development of fatal acute liver failure in HIV-HBV coinfected patients.

Publication ,  Journal Article
Anderson, AM; Mosunjac, MB; Palmore, MP; Osborn, MK; Muir, AJ
Published in: World J Gastroenterol
August 28, 2010

Coinfection with hepatitis B virus (HBV) is not uncommon in human immunodeficiency virus (HIV)-infected individuals and patients with HIV-HBV coinfection are at high risk for progression of liver disease. Current guidelines regarding the treatment of HIV infection recommend that patients who are coinfected with HIV and HBV receive highly active antiretroviral therapy (HAART) with activity against hepatitis B. While HIV-HBV coinfected patients often experience liver enzyme elevations after starting antiretroviral therapy, acute liver failure (ALF) is rare and typically occurs with older antiretroviral agents with known potential for hepatotoxicity. We describe two cases of fatal ALF in the setting of HIV-HBV coinfection after initiation of HAART. These cases occurred despite treatment with antiretrovirals that have activity against HBV and highlight the challenges in distinguishing drug hepatotoxicity and HBV immune reconstitution inflammatory syndrome. HIV-HBV coinfected patients should be monitored closely when initiating HAART, even when treatment includes agents that have activity against HBV.

Duke Scholars

Published In

World J Gastroenterol

DOI

EISSN

2219-2840

Publication Date

August 28, 2010

Volume

16

Issue

32

Start / End Page

4107 / 4111

Location

United States

Related Subject Headings

  • Male
  • Liver Failure, Acute
  • Liver
  • Humans
  • Hepatitis B virus
  • Hepatitis B
  • HIV Infections
  • HIV
  • Gastroenterology & Hepatology
  • Fatal Outcome
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Anderson, A. M., Mosunjac, M. B., Palmore, M. P., Osborn, M. K., & Muir, A. J. (2010). Development of fatal acute liver failure in HIV-HBV coinfected patients. World J Gastroenterol, 16(32), 4107–4111. https://doi.org/10.3748/wjg.v16.i32.4107
Anderson, Albert M., Marina B. Mosunjac, Melody P. Palmore, Melissa K. Osborn, and Andrew J. Muir. “Development of fatal acute liver failure in HIV-HBV coinfected patients.World J Gastroenterol 16, no. 32 (August 28, 2010): 4107–11. https://doi.org/10.3748/wjg.v16.i32.4107.
Anderson AM, Mosunjac MB, Palmore MP, Osborn MK, Muir AJ. Development of fatal acute liver failure in HIV-HBV coinfected patients. World J Gastroenterol. 2010 Aug 28;16(32):4107–11.
Anderson, Albert M., et al. “Development of fatal acute liver failure in HIV-HBV coinfected patients.World J Gastroenterol, vol. 16, no. 32, Aug. 2010, pp. 4107–11. Pubmed, doi:10.3748/wjg.v16.i32.4107.
Anderson AM, Mosunjac MB, Palmore MP, Osborn MK, Muir AJ. Development of fatal acute liver failure in HIV-HBV coinfected patients. World J Gastroenterol. 2010 Aug 28;16(32):4107–4111.

Published In

World J Gastroenterol

DOI

EISSN

2219-2840

Publication Date

August 28, 2010

Volume

16

Issue

32

Start / End Page

4107 / 4111

Location

United States

Related Subject Headings

  • Male
  • Liver Failure, Acute
  • Liver
  • Humans
  • Hepatitis B virus
  • Hepatitis B
  • HIV Infections
  • HIV
  • Gastroenterology & Hepatology
  • Fatal Outcome