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Drosophila, genetic screens, and cardiac function.

Publication ,  Journal Article
Wolf, MJ; Rockman, HA
Published in: Circ Res
September 16, 2011

The fruit fly, Drosophila melanogaster, has been used to study genetics, development, and signaling for nearly a century, but only over the past few decades has this tremendous resource been the focus of cardiovascular research. Fly genetics offers sophisticated transgenic systems, molecularly defined genomic deficiencies, genome-wide transgenic RNAi lines, and numerous curated mutants to perform genetic screens. As a genetically tractable model, the fly facilitates gene discovery and can complement mammalian models of disease. The circulatory system in the fly comprises well-defined sets of cardiomyocytes, and methodological advances have permitted accurate characterization of cardiac morphology and function. Thus, fly genetics and genomics offer new approaches for gene discovery of adult cardiac phenotypes to identify evolutionarily conserved molecular signals that drive cardiovascular disease.

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Published In

Circ Res

DOI

EISSN

1524-4571

Publication Date

September 16, 2011

Volume

109

Issue

7

Start / End Page

794 / 806

Location

United States

Related Subject Headings

  • Phenotype
  • Morphogenesis
  • Humans
  • Genetic Testing
  • Genetic Predisposition to Disease
  • Genetic Engineering
  • Gene Expression Regulation, Developmental
  • Drosophila melanogaster
  • Drosophila Proteins
  • Cardiovascular System & Hematology
 

Citation

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Wolf, M. J., & Rockman, H. A. (2011). Drosophila, genetic screens, and cardiac function. Circ Res, 109(7), 794–806. https://doi.org/10.1161/CIRCRESAHA.111.244897
Wolf, Matthew J., and Howard A. Rockman. “Drosophila, genetic screens, and cardiac function.Circ Res 109, no. 7 (September 16, 2011): 794–806. https://doi.org/10.1161/CIRCRESAHA.111.244897.
Wolf MJ, Rockman HA. Drosophila, genetic screens, and cardiac function. Circ Res. 2011 Sep 16;109(7):794–806.
Wolf, Matthew J., and Howard A. Rockman. “Drosophila, genetic screens, and cardiac function.Circ Res, vol. 109, no. 7, Sept. 2011, pp. 794–806. Pubmed, doi:10.1161/CIRCRESAHA.111.244897.
Wolf MJ, Rockman HA. Drosophila, genetic screens, and cardiac function. Circ Res. 2011 Sep 16;109(7):794–806.

Published In

Circ Res

DOI

EISSN

1524-4571

Publication Date

September 16, 2011

Volume

109

Issue

7

Start / End Page

794 / 806

Location

United States

Related Subject Headings

  • Phenotype
  • Morphogenesis
  • Humans
  • Genetic Testing
  • Genetic Predisposition to Disease
  • Genetic Engineering
  • Gene Expression Regulation, Developmental
  • Drosophila melanogaster
  • Drosophila Proteins
  • Cardiovascular System & Hematology