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Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling.

Publication ,  Journal Article
Shukla, AK; Xiao, K; Lefkowitz, RJ
Published in: Trends Biochem Sci
September 2011

β-Arrestins, originally discovered to desensitize activated seven transmembrane receptors (7TMRs; also known as G-protein-coupled receptors, GPCRs), are now well established mediators of receptor endocytosis, ubiquitylation and G protein-independent signaling. Recent global analyses of β-arrestin interactions and β-arrestin-dependent phosphorylation events have uncovered several previously unanticipated roles of β-arrestins in a range of cellular signaling events. These findings strongly suggest that the functional roles of β-arrestins are much broader than currently understood. Biophysical studies aimed at understanding multiple active conformations of the 7TMRs and the β-arrestins have begun to unravel the mechanistic basis for the diverse functional capabilities of β-arrestins in cellular signaling.

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Published In

Trends Biochem Sci

DOI

ISSN

0968-0004

Publication Date

September 2011

Volume

36

Issue

9

Start / End Page

457 / 469

Location

England

Related Subject Headings

  • beta-Arrestins
  • Ubiquitination
  • Species Specificity
  • Signal Transduction
  • Receptors, G-Protein-Coupled
  • Protein Transport
  • Protein Conformation
  • Phosphorylation
  • Phosphoproteins
  • Membrane Proteins
 

Citation

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Shukla, A. K., Xiao, K., & Lefkowitz, R. J. (2011). Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling. Trends Biochem Sci, 36(9), 457–469. https://doi.org/10.1016/j.tibs.2011.06.003
Shukla, Arun K., Kunhong Xiao, and Robert J. Lefkowitz. “Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling.Trends Biochem Sci 36, no. 9 (September 2011): 457–69. https://doi.org/10.1016/j.tibs.2011.06.003.
Shukla AK, Xiao K, Lefkowitz RJ. Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling. Trends Biochem Sci. 2011 Sep;36(9):457–69.
Shukla, Arun K., et al. “Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling.Trends Biochem Sci, vol. 36, no. 9, Sept. 2011, pp. 457–69. Pubmed, doi:10.1016/j.tibs.2011.06.003.
Shukla AK, Xiao K, Lefkowitz RJ. Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling. Trends Biochem Sci. 2011 Sep;36(9):457–469.
Journal cover image

Published In

Trends Biochem Sci

DOI

ISSN

0968-0004

Publication Date

September 2011

Volume

36

Issue

9

Start / End Page

457 / 469

Location

England

Related Subject Headings

  • beta-Arrestins
  • Ubiquitination
  • Species Specificity
  • Signal Transduction
  • Receptors, G-Protein-Coupled
  • Protein Transport
  • Protein Conformation
  • Phosphorylation
  • Phosphoproteins
  • Membrane Proteins