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A low-cost, portable, and quantitative spectral imaging system for application to biological tissues.

Publication ,  Journal Article
Fu, HL; Yu, B; Lo, JY; Palmer, GM; Kuech, TF; Ramanujam, N
Published in: Opt Express
June 7, 2010

The ability of diffuse reflectance spectroscopy to extract quantitative biological composition of tissues has been used to discern tissue types in both pre-clinical and clinical cancer studies. Typically, diffuse reflectance spectroscopy systems are designed for single-point measurements. Clinically, an imaging system would provide valuable spatial information on tissue composition. While it is feasible to build a multiplexed fiber-optic probe based spectral imaging system, these systems suffer from drawbacks with respect to cost and size. To address these we developed a compact and low cost system using a broadband light source with an 8-slot filter wheel for illumination and silicon photodiodes for detection. The spectral imaging system was tested on a set of tissue mimicking liquid phantoms which yielded an optical property extraction accuracy of 6.40 +/- 7.78% for the absorption coefficient (micro(a)) and 11.37 +/- 19.62% for the wavelength-averaged reduced scattering coefficient (micro(s)').

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Published In

Opt Express

DOI

EISSN

1094-4087

Publication Date

June 7, 2010

Volume

18

Issue

12

Start / End Page

12630 / 12645

Location

United States

Related Subject Headings

  • Spectrum Analysis
  • Phantoms, Imaging
  • Optics
  • Optical Phenomena
  • Imaging, Three-Dimensional
  • Computer Simulation
  • 5102 Atomic, molecular and optical physics
  • 4009 Electronics, sensors and digital hardware
  • 4006 Communications engineering
  • 1005 Communications Technologies
 

Citation

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Fu, H. L., Yu, B., Lo, J. Y., Palmer, G. M., Kuech, T. F., & Ramanujam, N. (2010). A low-cost, portable, and quantitative spectral imaging system for application to biological tissues. Opt Express, 18(12), 12630–12645. https://doi.org/10.1364/OE.18.012630
Fu, Henry L., Bing Yu, Justin Y. Lo, Greg M. Palmer, Thomas F. Kuech, and Nimmi Ramanujam. “A low-cost, portable, and quantitative spectral imaging system for application to biological tissues.Opt Express 18, no. 12 (June 7, 2010): 12630–45. https://doi.org/10.1364/OE.18.012630.
Fu HL, Yu B, Lo JY, Palmer GM, Kuech TF, Ramanujam N. A low-cost, portable, and quantitative spectral imaging system for application to biological tissues. Opt Express. 2010 Jun 7;18(12):12630–45.
Fu, Henry L., et al. “A low-cost, portable, and quantitative spectral imaging system for application to biological tissues.Opt Express, vol. 18, no. 12, June 2010, pp. 12630–45. Pubmed, doi:10.1364/OE.18.012630.
Fu HL, Yu B, Lo JY, Palmer GM, Kuech TF, Ramanujam N. A low-cost, portable, and quantitative spectral imaging system for application to biological tissues. Opt Express. 2010 Jun 7;18(12):12630–12645.
Journal cover image

Published In

Opt Express

DOI

EISSN

1094-4087

Publication Date

June 7, 2010

Volume

18

Issue

12

Start / End Page

12630 / 12645

Location

United States

Related Subject Headings

  • Spectrum Analysis
  • Phantoms, Imaging
  • Optics
  • Optical Phenomena
  • Imaging, Three-Dimensional
  • Computer Simulation
  • 5102 Atomic, molecular and optical physics
  • 4009 Electronics, sensors and digital hardware
  • 4006 Communications engineering
  • 1005 Communications Technologies