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Experimental detection of iron overload in liver through neutron stimulated emission spectroscopy.

Publication ,  Journal Article
Kapadia, AJ; Tourassi, GD; Sharma, AC; Crowell, AS; Kiser, MR; Howell, CR
Published in: Physics in medicine and biology
May 2008

Iron overload disorders have been the focus of several quantification studies involving non-invasive imaging modalities. Neutron spectroscopic techniques have demonstrated great potential in detecting iron concentrations within biological tissue. We are developing a neutron spectroscopic technique called neutron stimulated emission computed tomography (NSECT), which has the potential to diagnose iron overload in the liver at clinically acceptable patient dose levels through a non-invasive scan. The technique uses inelastic scatter interactions between atomic nuclei in the sample and incoming fast neutrons to non-invasively determine the concentration of elements in the sample. This paper discusses a non-tomographic application of NSECT investigating the feasibility of detecting elevated iron concentrations in the liver. A model of iron overload in the human body was created using bovine liver tissue housed inside a human torso phantom and was scanned with a 5 MeV pulsed beam using single-position spectroscopy. Spectra were reconstructed and analyzed with algorithms designed specifically for NSECT. Results from spectroscopic quantification indicate that NSECT can currently detect liver iron concentrations of 6 mg g(-1) or higher and has the potential to detect lower concentrations by optimizing the acquisition geometry to scan a larger volume of tissue. The experiment described in this paper has two important outcomes: (i) it demonstrates that NSECT has the potential to detect clinically relevant concentrations of iron in the human body through a non-invasive scan and (ii) it provides a comparative standard to guide the design of iron overload phantoms for future NSECT liver iron quantification studies.

Duke Scholars

Published In

Physics in medicine and biology

DOI

EISSN

1361-6560

ISSN

0031-9155

Publication Date

May 2008

Volume

53

Issue

10

Start / End Page

2633 / 2649

Related Subject Headings

  • Tomography, Emission-Computed
  • Sensitivity and Specificity
  • Radiation Dosage
  • Phantoms, Imaging
  • Nuclear Medicine & Medical Imaging
  • Neutrons
  • Liver
  • Iron Overload
  • Iron
  • Image Processing, Computer-Assisted
 

Citation

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Kapadia, A. J., Tourassi, G. D., Sharma, A. C., Crowell, A. S., Kiser, M. R., & Howell, C. R. (2008). Experimental detection of iron overload in liver through neutron stimulated emission spectroscopy. Physics in Medicine and Biology, 53(10), 2633–2649. https://doi.org/10.1088/0031-9155/53/10/013
Kapadia, A. J., G. D. Tourassi, A. C. Sharma, A. S. Crowell, M. R. Kiser, and C. R. Howell. “Experimental detection of iron overload in liver through neutron stimulated emission spectroscopy.Physics in Medicine and Biology 53, no. 10 (May 2008): 2633–49. https://doi.org/10.1088/0031-9155/53/10/013.
Kapadia AJ, Tourassi GD, Sharma AC, Crowell AS, Kiser MR, Howell CR. Experimental detection of iron overload in liver through neutron stimulated emission spectroscopy. Physics in medicine and biology. 2008 May;53(10):2633–49.
Kapadia, A. J., et al. “Experimental detection of iron overload in liver through neutron stimulated emission spectroscopy.Physics in Medicine and Biology, vol. 53, no. 10, May 2008, pp. 2633–49. Epmc, doi:10.1088/0031-9155/53/10/013.
Kapadia AJ, Tourassi GD, Sharma AC, Crowell AS, Kiser MR, Howell CR. Experimental detection of iron overload in liver through neutron stimulated emission spectroscopy. Physics in medicine and biology. 2008 May;53(10):2633–2649.
Journal cover image

Published In

Physics in medicine and biology

DOI

EISSN

1361-6560

ISSN

0031-9155

Publication Date

May 2008

Volume

53

Issue

10

Start / End Page

2633 / 2649

Related Subject Headings

  • Tomography, Emission-Computed
  • Sensitivity and Specificity
  • Radiation Dosage
  • Phantoms, Imaging
  • Nuclear Medicine & Medical Imaging
  • Neutrons
  • Liver
  • Iron Overload
  • Iron
  • Image Processing, Computer-Assisted