Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel

A longitudinal study of epigenetic variation in twins.

Publication ,  Journal Article
Wong, CCY; Caspi, A; Williams, B; Craig, IW; Houts, R; Ambler, A; Moffitt, TE; Mill, J
Published in: Epigenetics
August 2010

DNA methylation is a key epigenetic mechanism involved in the developmental regulation of gene expression. Alterations in DNA methylation are established contributors to inter-individual phenotypic variation and have been associated with disease susceptibility. The degree to which changes in loci-specific DNA methylation are under the influence of heritable and environmental factors is largely unknown. In this study, we quantitatively measured DNA methylation across the promoter regions of the dopamine receptor 4 gene (DRD4), the serotonin transporter gene (SLC6A4/SERT) and the X-linked monoamine oxidase A gene (MAOA) using DNA sampled at both ages 5 and 10 years in 46 MZ twin-pairs and 45 DZ twin-pairs (total n=182). Our data suggest that DNA methylation differences are apparent already in early childhood, even between genetically identical individuals, and that individual differences in methylation are not stable over time. Our longitudinal-developmental study suggests that environmental influences are important factors accounting for interindividual DNA methylation differences, and that these influences differ across the genome. The observation of dynamic changes in DNA methylation over time highlights the importance of longitudinal research designs for epigenetic research.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Epigenetics

DOI

EISSN

1559-2308

ISSN

1559-2294

Publication Date

August 2010

Volume

5

Issue

6

Start / End Page

516 / 526

Related Subject Headings

  • Twins
  • Serotonin Plasma Membrane Transport Proteins
  • Receptors, Dopamine D4
  • Monoamine Oxidase
  • Male
  • Longitudinal Studies
  • Inheritance Patterns
  • Humans
  • Genomic Instability
  • Genetic Variation
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wong, C. C. Y., Caspi, A., Williams, B., Craig, I. W., Houts, R., Ambler, A., … Mill, J. (2010). A longitudinal study of epigenetic variation in twins. Epigenetics, 5(6), 516–526. https://doi.org/10.4161/epi.5.6.12226
Wong, Chloe Chung Yi, Avshalom Caspi, Benjamin Williams, Ian W. Craig, Renate Houts, Antony Ambler, Terrie E. Moffitt, and Jonathan Mill. “A longitudinal study of epigenetic variation in twins.Epigenetics 5, no. 6 (August 2010): 516–26. https://doi.org/10.4161/epi.5.6.12226.
Wong CCY, Caspi A, Williams B, Craig IW, Houts R, Ambler A, et al. A longitudinal study of epigenetic variation in twins. Epigenetics. 2010 Aug;5(6):516–26.
Wong, Chloe Chung Yi, et al. “A longitudinal study of epigenetic variation in twins.Epigenetics, vol. 5, no. 6, Aug. 2010, pp. 516–26. Epmc, doi:10.4161/epi.5.6.12226.
Wong CCY, Caspi A, Williams B, Craig IW, Houts R, Ambler A, Moffitt TE, Mill J. A longitudinal study of epigenetic variation in twins. Epigenetics. 2010 Aug;5(6):516–526.

Published In

Epigenetics

DOI

EISSN

1559-2308

ISSN

1559-2294

Publication Date

August 2010

Volume

5

Issue

6

Start / End Page

516 / 526

Related Subject Headings

  • Twins
  • Serotonin Plasma Membrane Transport Proteins
  • Receptors, Dopamine D4
  • Monoamine Oxidase
  • Male
  • Longitudinal Studies
  • Inheritance Patterns
  • Humans
  • Genomic Instability
  • Genetic Variation