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Reduction of dorsolateral prefrontal cortex gray matter in late-life depression.

Publication ,  Journal Article
Chang, C-C; Yu, S-C; McQuoid, DR; Messer, DF; Taylor, WD; Singh, K; Boyd, BD; Krishnan, KRR; MacFall, JR; Steffens, DC; Payne, ME
Published in: Psychiatry Res
July 30, 2011

Postmortem studies have documented abnormalities in the dorsolateral prefrontal cortex (dlPFC) in depressed subjects. In this study we used magnetic resonance imaging to test for dlPFC volume differences between older depressed and non-depressed individuals. Eighty-eight subjects meeting DSM IV criteria for major depressive disorder and thirty-five control subjects completed clinical evaluations and cranial 3T magnetic resonance imaging. After tissue types were identified using an automated segmentation process, the dlPFC was measured in both hemispheres using manual delineation based on anatomical landmarks. Depressed subjects had significantly lower gray matter in the left and right dorsolateral prefrontal cortex (standardized to cerebral parenchyma) after controlling for age and sex. Our study confirmed the reduction of dorsolateral prefrontal cortex in elderly depressed subjects, especially in the gray matter. These regional abnormalities may be associated with psychopathological changes in late-life depression.

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Published In

Psychiatry Res

DOI

ISSN

0165-1781

Publication Date

July 30, 2011

Volume

193

Issue

1

Start / End Page

1 / 6

Location

Ireland

Related Subject Headings

  • Reproducibility of Results
  • Psychiatry
  • Prefrontal Cortex
  • Middle Aged
  • Mental Status Schedule
  • Male
  • Magnetic Resonance Imaging
  • Linear Models
  • Image Processing, Computer-Assisted
  • Humans
 

Citation

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Chang, C.-C., Yu, S.-C., McQuoid, D. R., Messer, D. F., Taylor, W. D., Singh, K., … Payne, M. E. (2011). Reduction of dorsolateral prefrontal cortex gray matter in late-life depression. Psychiatry Res, 193(1), 1–6. https://doi.org/10.1016/j.pscychresns.2011.01.003
Chang, Cheng-Chen, Shun-Chieh Yu, Douglas R. McQuoid, Denise F. Messer, Warren D. Taylor, Kulpreet Singh, Brian D. Boyd, et al. “Reduction of dorsolateral prefrontal cortex gray matter in late-life depression.Psychiatry Res 193, no. 1 (July 30, 2011): 1–6. https://doi.org/10.1016/j.pscychresns.2011.01.003.
Chang C-C, Yu S-C, McQuoid DR, Messer DF, Taylor WD, Singh K, et al. Reduction of dorsolateral prefrontal cortex gray matter in late-life depression. Psychiatry Res. 2011 Jul 30;193(1):1–6.
Chang, Cheng-Chen, et al. “Reduction of dorsolateral prefrontal cortex gray matter in late-life depression.Psychiatry Res, vol. 193, no. 1, July 2011, pp. 1–6. Pubmed, doi:10.1016/j.pscychresns.2011.01.003.
Chang C-C, Yu S-C, McQuoid DR, Messer DF, Taylor WD, Singh K, Boyd BD, Krishnan KRR, MacFall JR, Steffens DC, Payne ME. Reduction of dorsolateral prefrontal cortex gray matter in late-life depression. Psychiatry Res. 2011 Jul 30;193(1):1–6.
Journal cover image

Published In

Psychiatry Res

DOI

ISSN

0165-1781

Publication Date

July 30, 2011

Volume

193

Issue

1

Start / End Page

1 / 6

Location

Ireland

Related Subject Headings

  • Reproducibility of Results
  • Psychiatry
  • Prefrontal Cortex
  • Middle Aged
  • Mental Status Schedule
  • Male
  • Magnetic Resonance Imaging
  • Linear Models
  • Image Processing, Computer-Assisted
  • Humans