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Genetic dissection of the mouse CNS using magnetic resonance microscopy.

Publication ,  Journal Article
Badea, A; Johnson, GA; Williams, RW
Published in: Curr Opin Neurol
August 2009

PURPOSE OF REVIEW: Advances in magnetic resonance microscopy (MRM) make it practical to map gene variants responsible for structural variation in brains of many species, including mice and humans. We review results of a systematic genetic analysis of MRM data using as a case study a family of well characterized lines of mice. RECENT ADVANCES: MRM has matured to the point that we can generate high contrast, high-resolution images even for species as small as a mouse, with a brain merely 1/3000th the size of humans. We generated 21.5-micron data sets for a diverse panel of BXD mouse strains to gauge the extent of genetic variation, and as a prelude to comprehensive genetic and genomic analyses. Here we review MRM capabilities and image segmentation methods; heritability of brain variation; covariation of the sizes of brain regions; and correlations between MRM and classical histological data sets. SUMMARY: The combination of high throughput MRM and genomics will improve our understanding of the genetic basis of structure-function correlations. Sophisticated mouse models will be critical in converting correlations into mechanisms and in determining genetic and epigenetic causes of differences in disease susceptibility.

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Published In

Curr Opin Neurol

DOI

EISSN

1473-6551

Publication Date

August 2009

Volume

22

Issue

4

Start / End Page

379 / 386

Location

England

Related Subject Headings

  • Neurology & Neurosurgery
  • Models, Animal
  • Microscopy
  • Mice
  • Magnetic Resonance Imaging
  • Genomics
  • Brain Mapping
  • Brain
  • Animals
  • 3209 Neurosciences
 

Citation

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ICMJE
MLA
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Badea, A., Johnson, G. A., & Williams, R. W. (2009). Genetic dissection of the mouse CNS using magnetic resonance microscopy. Curr Opin Neurol, 22(4), 379–386. https://doi.org/10.1097/WCO.0b013e32832d9b86
Badea, Alexandra, G Allan Johnson, and Robert W. Williams. “Genetic dissection of the mouse CNS using magnetic resonance microscopy.Curr Opin Neurol 22, no. 4 (August 2009): 379–86. https://doi.org/10.1097/WCO.0b013e32832d9b86.
Badea A, Johnson GA, Williams RW. Genetic dissection of the mouse CNS using magnetic resonance microscopy. Curr Opin Neurol. 2009 Aug;22(4):379–86.
Badea, Alexandra, et al. “Genetic dissection of the mouse CNS using magnetic resonance microscopy.Curr Opin Neurol, vol. 22, no. 4, Aug. 2009, pp. 379–86. Pubmed, doi:10.1097/WCO.0b013e32832d9b86.
Badea A, Johnson GA, Williams RW. Genetic dissection of the mouse CNS using magnetic resonance microscopy. Curr Opin Neurol. 2009 Aug;22(4):379–386.

Published In

Curr Opin Neurol

DOI

EISSN

1473-6551

Publication Date

August 2009

Volume

22

Issue

4

Start / End Page

379 / 386

Location

England

Related Subject Headings

  • Neurology & Neurosurgery
  • Models, Animal
  • Microscopy
  • Mice
  • Magnetic Resonance Imaging
  • Genomics
  • Brain Mapping
  • Brain
  • Animals
  • 3209 Neurosciences