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Remote sites of structural atrophy predict later amyloid formation in a mouse model of Alzheimer's disease.

Publication ,  Journal Article
Badea, A; Johnson, GA; Jankowsky, JL
Published in: Neuroimage
April 1, 2010

Magnetic resonance (MR) imaging can provide a longitudinal view of neurological disease through repeated imaging of patients at successive stages of impairment. Until recently, the difficulty of manual delineation has limited volumetric analyses of MR data sets to a few select regions and a small number of subjects. Increased throughput offered by faster imaging methods, automated segmentation, and deformation-based morphometry have recently been applied to overcome this limitation with mouse models of neurological conditions. We use automated analyses to produce an unbiased view of volumetric changes in a transgenic mouse model for Alzheimer's disease (AD) at two points in the progression of disease: immediately before and shortly after the onset of amyloid formation. In addition to the cortex and hippocampus, where atrophy has been well documented in AD patients, we identify volumetric losses in the pons and substantia nigra where neurodegeneration has not been carefully examined. We find that deficits in cortical volume precede amyloid formation in this mouse model, similar to presymptomatic atrophy seen in patients with familial AD. Unexpectedly, volumetric losses identified by MR outside of the forebrain predict locations of future amyloid formation, such as the inferior colliculus and spinal nuclei, which develop pathology at very late stages of disease. Our work provides proof-of-principle that MR microscopy can expand our view of AD by offering a complete and unbiased examination of volumetric changes that guide us in revisiting the canonical neuropathology.

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Published In

Neuroimage

DOI

EISSN

1095-9572

Publication Date

April 1, 2010

Volume

50

Issue

2

Start / End Page

416 / 427

Location

United States

Related Subject Headings

  • Plaque, Amyloid
  • Neurology & Neurosurgery
  • Mice, Transgenic
  • Mice
  • Male
  • Magnetic Resonance Imaging
  • Image Interpretation, Computer-Assisted
  • Female
  • Disease Models, Animal
  • Brain
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Badea, A., Johnson, G. A., & Jankowsky, J. L. (2010). Remote sites of structural atrophy predict later amyloid formation in a mouse model of Alzheimer's disease. Neuroimage, 50(2), 416–427. https://doi.org/10.1016/j.neuroimage.2009.12.070
Badea, Alexandra, G Allan Johnson, and Joanna L. Jankowsky. “Remote sites of structural atrophy predict later amyloid formation in a mouse model of Alzheimer's disease.Neuroimage 50, no. 2 (April 1, 2010): 416–27. https://doi.org/10.1016/j.neuroimage.2009.12.070.
Badea A, Johnson GA, Jankowsky JL. Remote sites of structural atrophy predict later amyloid formation in a mouse model of Alzheimer's disease. Neuroimage. 2010 Apr 1;50(2):416–27.
Badea, Alexandra, et al. “Remote sites of structural atrophy predict later amyloid formation in a mouse model of Alzheimer's disease.Neuroimage, vol. 50, no. 2, Apr. 2010, pp. 416–27. Pubmed, doi:10.1016/j.neuroimage.2009.12.070.
Badea A, Johnson GA, Jankowsky JL. Remote sites of structural atrophy predict later amyloid formation in a mouse model of Alzheimer's disease. Neuroimage. 2010 Apr 1;50(2):416–427.
Journal cover image

Published In

Neuroimage

DOI

EISSN

1095-9572

Publication Date

April 1, 2010

Volume

50

Issue

2

Start / End Page

416 / 427

Location

United States

Related Subject Headings

  • Plaque, Amyloid
  • Neurology & Neurosurgery
  • Mice, Transgenic
  • Mice
  • Male
  • Magnetic Resonance Imaging
  • Image Interpretation, Computer-Assisted
  • Female
  • Disease Models, Animal
  • Brain