A validated chiral HPLC method for the enantiomeric separation of tolterodine tartarate.
Publication
, Journal Article
Kumar, YR; Ramulu, G; Vevakanand, VV; Vaidyanathan, G; Srinivas, K; Kumar, MK; Mukkanti, K; Reddy, MS; Venkatraman, S; Suryanarayana, MV
Published in: J Pharm Biomed Anal
September 3, 2004
An isocratic chiral HPLC method was developed for the separation of tolterodine tartarate enantiomers. The mobile phase consists of n-hexane and isopropyl alcohol in the ratio of 980:20 (v/v) with 1 ml diethylamine and 0.6 ml trifluoroacetic acid. Chiralcel OD-H (250 mm x 4.6mm) column was used at constant room temperature. Flow rate was kept at 0.5 ml/min. This method is capable of detecting the S-isomer up to 0.1 microg/ml. The method was validated in terms of linearity, precision, limit of detection (LOD) and limit of quantification (LOQ).
Duke Scholars
Published In
J Pharm Biomed Anal
DOI
ISSN
0731-7085
Publication Date
September 3, 2004
Volume
35
Issue
5
Start / End Page
1279 / 1285
Location
England
Related Subject Headings
- Tolterodine Tartrate
- Stereoisomerism
- Reproducibility of Results
- Phenylpropanolamine
- Molecular Structure
- Cresols
- Chromatography, High Pressure Liquid
- Benzhydryl Compounds
- Analytical Chemistry
- 3401 Analytical chemistry
Citation
APA
Chicago
ICMJE
MLA
NLM
Kumar, Y. R., Ramulu, G., Vevakanand, V. V., Vaidyanathan, G., Srinivas, K., Kumar, M. K., … Suryanarayana, M. V. (2004). A validated chiral HPLC method for the enantiomeric separation of tolterodine tartarate. J Pharm Biomed Anal, 35(5), 1279–1285. https://doi.org/10.1016/j.jpba.2004.03.026
Kumar, Y Ravindra, G. Ramulu, V. V. Vevakanand, Gopal Vaidyanathan, Keesari Srinivas, M Kishore Kumar, K. Mukkanti, M Satyanarayana Reddy, S. Venkatraman, and M. V. Suryanarayana. “A validated chiral HPLC method for the enantiomeric separation of tolterodine tartarate.” J Pharm Biomed Anal 35, no. 5 (September 3, 2004): 1279–85. https://doi.org/10.1016/j.jpba.2004.03.026.
Kumar YR, Ramulu G, Vevakanand VV, Vaidyanathan G, Srinivas K, Kumar MK, et al. A validated chiral HPLC method for the enantiomeric separation of tolterodine tartarate. J Pharm Biomed Anal. 2004 Sep 3;35(5):1279–85.
Kumar, Y. Ravindra, et al. “A validated chiral HPLC method for the enantiomeric separation of tolterodine tartarate.” J Pharm Biomed Anal, vol. 35, no. 5, Sept. 2004, pp. 1279–85. Pubmed, doi:10.1016/j.jpba.2004.03.026.
Kumar YR, Ramulu G, Vevakanand VV, Vaidyanathan G, Srinivas K, Kumar MK, Mukkanti K, Reddy MS, Venkatraman S, Suryanarayana MV. A validated chiral HPLC method for the enantiomeric separation of tolterodine tartarate. J Pharm Biomed Anal. 2004 Sep 3;35(5):1279–1285.
Published In
J Pharm Biomed Anal
DOI
ISSN
0731-7085
Publication Date
September 3, 2004
Volume
35
Issue
5
Start / End Page
1279 / 1285
Location
England
Related Subject Headings
- Tolterodine Tartrate
- Stereoisomerism
- Reproducibility of Results
- Phenylpropanolamine
- Molecular Structure
- Cresols
- Chromatography, High Pressure Liquid
- Benzhydryl Compounds
- Analytical Chemistry
- 3401 Analytical chemistry