Calcineurin inhibition or mutation enhances cell wall inhibitors against Aspergillus fumigatus.
Journal articles
- Journal Article
Steinbach, WJ; Cramer, RA; Perfect, BZ; Henn, C; Nielsen, K; Heitman, J; Perfect, JR
Published in: Antimicrob Agents Chemother
August 2007
Calcineurin mutation or inhibition enhanced the antifungal morphological effect of cell wall inhibitors caspofungin or nikkomycin Z against Aspergillus fumigatus. Quantification of 1,3-beta-d-glucan revealed decreased amounts in the calcineurin A (DeltacnaA) mutant. Calcineurin can be an excellent adjunct therapeutic target in combination with other cell wall inhibitors against A. fumigatus.
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Published In
Antimicrob Agents Chemother
DOI
ISSN
0066-4804
Publication Date
August 2007
Volume
51
Issue
8
Start / End Page
2979 / 2981
Location
United States
Related Subject Headings
- Tacrolimus
- Peptides, Cyclic
- Mutation
- Microbiology
- Microbial Sensitivity Tests
- Lipopeptides
- Humans
- Gene Expression Regulation, Fungal
- Enzyme Inhibitors
- Echinocandins
Citation
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Steinbach, W. J., Cramer, R. A., Perfect, B. Z., Henn, C., Nielsen, K., Heitman, J., & Perfect, J. R. (2007). Calcineurin inhibition or mutation enhances cell wall inhibitors against Aspergillus fumigatus. Antimicrob Agents Chemother, 51(8), 2979–2981. https://doi.org/10.1128/AAC.01394-06
Steinbach, William J., Robert A. Cramer, B Zachary Perfect, Christina Henn, Kirsten Nielsen, Joseph Heitman, and John R. Perfect. “Calcineurin inhibition or mutation enhances cell wall inhibitors against Aspergillus fumigatus.” Antimicrob Agents Chemother 51, no. 8 (August 2007): 2979–81. https://doi.org/10.1128/AAC.01394-06.
Steinbach WJ, Cramer RA, Perfect BZ, Henn C, Nielsen K, Heitman J, et al. Calcineurin inhibition or mutation enhances cell wall inhibitors against Aspergillus fumigatus. Antimicrob Agents Chemother. 2007 Aug;51(8):2979–81.
Steinbach, William J., et al. “Calcineurin inhibition or mutation enhances cell wall inhibitors against Aspergillus fumigatus.” Antimicrob Agents Chemother, vol. 51, no. 8, Aug. 2007, pp. 2979–81. Pubmed, doi:10.1128/AAC.01394-06.
Steinbach WJ, Cramer RA, Perfect BZ, Henn C, Nielsen K, Heitman J, Perfect JR. Calcineurin inhibition or mutation enhances cell wall inhibitors against Aspergillus fumigatus. Antimicrob Agents Chemother. 2007 Aug;51(8):2979–2981.
Published In
Antimicrob Agents Chemother
DOI
ISSN
0066-4804
Publication Date
August 2007
Volume
51
Issue
8
Start / End Page
2979 / 2981
Location
United States
Related Subject Headings
- Tacrolimus
- Peptides, Cyclic
- Mutation
- Microbiology
- Microbial Sensitivity Tests
- Lipopeptides
- Humans
- Gene Expression Regulation, Fungal
- Enzyme Inhibitors
- Echinocandins