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The role of proteolytic cellular systems in trabecular meshwork homeostasis.

Publication ,  Journal Article
Liton, PB; Gonzalez, P; Epstein, DL
Published in: Exp Eye Res
April 2009

The molecular mechanisms contributing to the progressive malfunction of the trabecular meshwork (TM)/Schlemm's canal (SC) conventional outflow pathway during aging and in Primary Open Angle Glaucoma (POAG) are still poorly understood. Progressive accumulation of damaged and cross-linked proteins is a hallmark of aging tissues and has been proposed to play a major role in the tissue abnormalities associated with organismal aging and many age-related diseases. Such progressive accumulation of damaged proteins with age is believed to result from both, increased oxidative stress that results in faster rates of protein damage, as well as from a functional decline in the cellular proteolytic machinery that eliminates misfolded and damaged proteins. Here, we review the reported data that supports the occurrence of oxidative damage and the alterations in the intracellular proteolytic systems in the TM in aging and POAG. Finally, we discuss how the functional decline of the cellular proteolytic machinery in the TM might lead to the observed physiologic alterations of the outflow pathway in glaucoma.

Duke Scholars

Published In

Exp Eye Res

DOI

EISSN

1096-0007

Publication Date

April 2009

Volume

88

Issue

4

Start / End Page

724 / 728

Location

England

Related Subject Headings

  • Trabecular Meshwork
  • Proteasome Endopeptidase Complex
  • Oxidative Stress
  • Ophthalmology & Optometry
  • Lysosomes
  • Humans
  • Homeostasis
  • Glaucoma, Open-Angle
  • Eye Proteins
  • Calpain
 

Citation

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Liton, P. B., Gonzalez, P., & Epstein, D. L. (2009). The role of proteolytic cellular systems in trabecular meshwork homeostasis. Exp Eye Res, 88(4), 724–728. https://doi.org/10.1016/j.exer.2008.11.002
Liton, Paloma B., Pedro Gonzalez, and David L. Epstein. “The role of proteolytic cellular systems in trabecular meshwork homeostasis.Exp Eye Res 88, no. 4 (April 2009): 724–28. https://doi.org/10.1016/j.exer.2008.11.002.
Liton PB, Gonzalez P, Epstein DL. The role of proteolytic cellular systems in trabecular meshwork homeostasis. Exp Eye Res. 2009 Apr;88(4):724–8.
Liton, Paloma B., et al. “The role of proteolytic cellular systems in trabecular meshwork homeostasis.Exp Eye Res, vol. 88, no. 4, Apr. 2009, pp. 724–28. Pubmed, doi:10.1016/j.exer.2008.11.002.
Liton PB, Gonzalez P, Epstein DL. The role of proteolytic cellular systems in trabecular meshwork homeostasis. Exp Eye Res. 2009 Apr;88(4):724–728.
Journal cover image

Published In

Exp Eye Res

DOI

EISSN

1096-0007

Publication Date

April 2009

Volume

88

Issue

4

Start / End Page

724 / 728

Location

England

Related Subject Headings

  • Trabecular Meshwork
  • Proteasome Endopeptidase Complex
  • Oxidative Stress
  • Ophthalmology & Optometry
  • Lysosomes
  • Humans
  • Homeostasis
  • Glaucoma, Open-Angle
  • Eye Proteins
  • Calpain