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Effect of BRCA1 and BRCA2 on the association between breast cancer risk and family history.

Publication ,  Journal Article
Claus, EB; Schildkraut, J; Iversen, ES; Berry, D; Parmigiani, G
Published in: J Natl Cancer Inst
December 2, 1998

BACKGROUND: The discovery of BRCA1 and BRCA2 has led to a reassessment of the association between family history of breast/ovarian cancer and breast cancer risk after controlling for carrier status for mutations in the BRCA1 and BRCA2 genes. We examined whether family history of breast cancer remains a predictive risk factor for this disease after carrier status for BRCA1 and/or BRCA2 mutations is taken into consideration. METHODS: The data are from 4730 case subjects with breast cancer and 4688 control subjects enrolled in the Cancer and Steroid Hormone Study. The probability of being a BRCA1 and/or BRCA2 gene carrier was calculated for each woman. Among predicted noncarriers, logistic regression was used to assess the relationship (odds ratios and 95% confidence intervals [CIs]) between case or control status and family history of breast or ovarian cancer. Estimates of age-specific breast cancer risk are presented by predicted carrier status. RESULTS: Among predicted noncarriers, case subjects were 2.06 times (95% CI = 1.69-2.50) and 1.24 times (95% CI = 1.17-1.32) more likely to report a first-degree or second-degree family history of breast cancer, respectively, than were control subjects. Case subjects were 1.99 times (95% CI = 1.63-2.44), 1.66 times (95% CI = 1.18-2.38), and 2.23 times (95% CI = 0.21-24.65) more likely to report an affected mother, sister, or both, respectively, than were control subjects. A family history of ovarian cancer was not statistically significantly associated with breast cancer risk. Noncarriers were predicted to have a lifetime risk of 9% of developing breast cancer compared with a 63% risk for carriers. CONCLUSIONS: Among women with a moderate family history of breast cancer, i.e., predicted noncarriers of BRCA1 and/or BRCA2 mutations, family history remains a factor in predicting breast cancer risk. In families with breast and ovarian cancers, the aggregation of these two cancers appears to be explained by BRCA1/BRCA2 mutation-carrier probability.

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Published In

J Natl Cancer Inst

DOI

ISSN

0027-8874

Publication Date

December 2, 1998

Volume

90

Issue

23

Start / End Page

1824 / 1829

Location

United States

Related Subject Headings

  • Risk Factors
  • Risk
  • Predictive Value of Tests
  • Oncology & Carcinogenesis
  • Odds Ratio
  • Mutation
  • Middle Aged
  • Logistic Models
  • Humans
  • Heterozygote
 

Citation

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Chicago
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MLA
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Claus, E. B., Schildkraut, J., Iversen, E. S., Berry, D., & Parmigiani, G. (1998). Effect of BRCA1 and BRCA2 on the association between breast cancer risk and family history. J Natl Cancer Inst, 90(23), 1824–1829. https://doi.org/10.1093/jnci/90.23.1824
Claus, E. B., J. Schildkraut, E. S. Iversen, D. Berry, and G. Parmigiani. “Effect of BRCA1 and BRCA2 on the association between breast cancer risk and family history.J Natl Cancer Inst 90, no. 23 (December 2, 1998): 1824–29. https://doi.org/10.1093/jnci/90.23.1824.
Claus EB, Schildkraut J, Iversen ES, Berry D, Parmigiani G. Effect of BRCA1 and BRCA2 on the association between breast cancer risk and family history. J Natl Cancer Inst. 1998 Dec 2;90(23):1824–9.
Claus, E. B., et al. “Effect of BRCA1 and BRCA2 on the association between breast cancer risk and family history.J Natl Cancer Inst, vol. 90, no. 23, Dec. 1998, pp. 1824–29. Pubmed, doi:10.1093/jnci/90.23.1824.
Claus EB, Schildkraut J, Iversen ES, Berry D, Parmigiani G. Effect of BRCA1 and BRCA2 on the association between breast cancer risk and family history. J Natl Cancer Inst. 1998 Dec 2;90(23):1824–1829.
Journal cover image

Published In

J Natl Cancer Inst

DOI

ISSN

0027-8874

Publication Date

December 2, 1998

Volume

90

Issue

23

Start / End Page

1824 / 1829

Location

United States

Related Subject Headings

  • Risk Factors
  • Risk
  • Predictive Value of Tests
  • Oncology & Carcinogenesis
  • Odds Ratio
  • Mutation
  • Middle Aged
  • Logistic Models
  • Humans
  • Heterozygote