Scholars@Duke publication: Inhaled nitric oxide therapy increases blood nitrite, nitrate, and s-nitrosohemoglobin concentrations in infants with pulmonary hypertension.

Inhaled nitric oxide therapy increases blood nitrite, nitrate, and s-nitrosohemoglobin concentrations in infants with pulmonary hypertension.

Publication , Journal Article

Ibrahim, YI; Ninnis, JR; Hopper, AO; Deming, DD; Zhang, AX; Herring, JL; Sowers, LC; McMahon, TJ; Power, GG; Blood, AB

Published in: J Pediatr

February 2012

OBJECTIVE: To measure the circulating concentrations of nitric oxide (NO) adducts with NO bioactivity after inhaled NO (iNO) therapy in infants with pulmonary hypertension. STUDY DESIGN: In this single center study, 5 sequential blood samples were collected from infants with pulmonary hypertension before, during, and after therapy with iNO (n = 17). Samples were collected from a control group of hospitalized infants without pulmonary hypertension (n = 16) and from healthy adults for comparison (n = 12). RESULTS: After beginning iNO (20 ppm) whole blood nitrite levels increased approximately two-fold within 2 hours (P<.01). Whole blood nitrate levels increased to 4-fold higher than baseline during treatment with 20 ppm iNO (P<.01). S-nitrosohemoglobin increased measurably after beginning iNO (P<.01), whereas iron nitrosyl hemoglobin and total hemoglobin-bound NO-species compounds did not change. CONCLUSION: Treatment of pulmonary hypertensive infants with iNO results in increases in levels of nitrite, nitrate, and S-nitrosohemoglobin in circulating blood. We speculate that these compounds may be carriers of NO bioactivity throughout the body and account for peripheral effects of iNO in the brain, heart, and other organs.

Duke Scholars

Author Timothy Joseph McMahon Medicine, Pulmonary, Allergy, and Critical Care Medicine

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Published In

J Pediatr

DOI

10.1016/j.jpeds.2011.07.040

EISSN

1097-6833

Publication Date

February 2012

Volume

160

Issue

Start / End Page

245 / 251

Location

United States

Related Subject Headings

Vasodilator Agents
Treatment Outcome
Pediatrics
Nitrites
Nitric Oxide
Nitrates
Male
Infant, Newborn
Infant
Hypertension, Pulmonary

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Ibrahim, Y. I., Ninnis, J. R., Hopper, A. O., Deming, D. D., Zhang, A. X., Herring, J. L., … Blood, A. B. (2012). Inhaled nitric oxide therapy increases blood nitrite, nitrate, and s-nitrosohemoglobin concentrations in infants with pulmonary hypertension. J Pediatr, 160(2), 245–251. https://doi.org/10.1016/j.jpeds.2011.07.040

Ibrahim, Yomna I., Janet R. Ninnis, Andrew O. Hopper, Douglas D. Deming, Amy X. Zhang, Jason L. Herring, Lawrence C. Sowers, Timothy J. McMahon, Gordon G. Power, and Arlin B. Blood. “Inhaled nitric oxide therapy increases blood nitrite, nitrate, and s-nitrosohemoglobin concentrations in infants with pulmonary hypertension.” J Pediatr 160, no. 2 (February 2012): 245–51. https://doi.org/10.1016/j.jpeds.2011.07.040.

Ibrahim YI, Ninnis JR, Hopper AO, Deming DD, Zhang AX, Herring JL, et al. Inhaled nitric oxide therapy increases blood nitrite, nitrate, and s-nitrosohemoglobin concentrations in infants with pulmonary hypertension. J Pediatr. 2012 Feb;160(2):245–51.

Ibrahim, Yomna I., et al. “Inhaled nitric oxide therapy increases blood nitrite, nitrate, and s-nitrosohemoglobin concentrations in infants with pulmonary hypertension.” J Pediatr, vol. 160, no. 2, Feb. 2012, pp. 245–51. Pubmed, doi:10.1016/j.jpeds.2011.07.040.

Ibrahim YI, Ninnis JR, Hopper AO, Deming DD, Zhang AX, Herring JL, Sowers LC, McMahon TJ, Power GG, Blood AB. Inhaled nitric oxide therapy increases blood nitrite, nitrate, and s-nitrosohemoglobin concentrations in infants with pulmonary hypertension. J Pediatr. 2012 Feb;160(2):245–251.