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Changes in pancreatic tryptophan in the rat in response to fasting. The effect of B-cytotoxic agents and variation through the oestrous cycle.

Publication ,  Journal Article
Bender, DA; Armstrong, AJ; Monkhouse, CR; Richardson, JP
Published in: Pflugers Arch
1975

The concentration of tryptophan not incorporated into protein or polypeptides in the pancreas of male rats rose two- to three-fold in response to a 24 hrs period of food deprivation. On refeeding or intra-peritoneal administration of glucose the level of tryptophan in the pancreas fell, while that in the serum rose. The pancrease B-cytotoxic agents alloxan and streptozotocin both abolished this response to fasting, while neutral red (an A-cytotoxic agent) had no effect. It therefore appears that the tryptophan which accumulates in the pancreas during fasting is located mainly in the B-cells of the Islets of Langerhans. In female rats, the concentration of tryptophan in the pancreas was greater at dioestrus than at any other stage of the oestrous cycle. The increase in pancreatic tryptophan was maximal at metoestrus and minimal at oestrus.

Duke Scholars

Published In

Pflugers Arch

DOI

ISSN

0031-6768

Publication Date

1975

Volume

356

Issue

3

Start / End Page

245 / 251

Location

Germany

Related Subject Headings

  • Tryptophan
  • Streptozocin
  • Rats
  • Pregnancy
  • Physiology
  • Pancreas
  • Islets of Langerhans
  • Glucose
  • Female
  • Fasting
 

Citation

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Bender, D. A., Armstrong, A. J., Monkhouse, C. R., & Richardson, J. P. (1975). Changes in pancreatic tryptophan in the rat in response to fasting. The effect of B-cytotoxic agents and variation through the oestrous cycle. Pflugers Arch, 356(3), 245–251. https://doi.org/10.1007/BF00583836
Bender, D. A., A. J. Armstrong, C. R. Monkhouse, and J. P. Richardson. “Changes in pancreatic tryptophan in the rat in response to fasting. The effect of B-cytotoxic agents and variation through the oestrous cycle.Pflugers Arch 356, no. 3 (1975): 245–51. https://doi.org/10.1007/BF00583836.
Bender, D. A., et al. “Changes in pancreatic tryptophan in the rat in response to fasting. The effect of B-cytotoxic agents and variation through the oestrous cycle.Pflugers Arch, vol. 356, no. 3, 1975, pp. 245–51. Pubmed, doi:10.1007/BF00583836.

Published In

Pflugers Arch

DOI

ISSN

0031-6768

Publication Date

1975

Volume

356

Issue

3

Start / End Page

245 / 251

Location

Germany

Related Subject Headings

  • Tryptophan
  • Streptozocin
  • Rats
  • Pregnancy
  • Physiology
  • Pancreas
  • Islets of Langerhans
  • Glucose
  • Female
  • Fasting