Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

Targeting the epigenome in ovarian cancer.

Publication ,  Journal Article
Murphy, SK
Published in: Future Oncol
February 2012

Epithelial ovarian cancer is the leading cause of death from gynecological cancers, largely owing to the development of recurrent intractable disease. Only a small number of distinct genetic mutations are known to contribute to ovarian carcinogenesis. Furthermore, understanding mechanistic genotype-phenotype links is complicated by frequent aneuploidy. Epigenetic deregulation is even more prominent, and ovarian cancers are replete with such aberrations that repress tumor suppressors and activate proto-oncogenes. Epigenetic therapies are emerging as promising agents for resensitizing platinum-resistant ovarian cancers. These drugs may also have the potential to alter epigenetic programming in cancer progenitor cells and provide a strategy for improving therapy of ovarian cancer.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Future Oncol

DOI

EISSN

1744-8301

Publication Date

February 2012

Volume

8

Issue

2

Start / End Page

151 / 164

Location

England

Related Subject Headings

  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Molecular Targeted Therapy
  • Humans
  • Female
  • Epigenesis, Genetic
  • Antineoplastic Agents
  • Animals
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Murphy, S. K. (2012). Targeting the epigenome in ovarian cancer. Future Oncol, 8(2), 151–164. https://doi.org/10.2217/fon.11.152
Murphy, Susan K. “Targeting the epigenome in ovarian cancer.Future Oncol 8, no. 2 (February 2012): 151–64. https://doi.org/10.2217/fon.11.152.
Murphy SK. Targeting the epigenome in ovarian cancer. Future Oncol. 2012 Feb;8(2):151–64.
Murphy, Susan K. “Targeting the epigenome in ovarian cancer.Future Oncol, vol. 8, no. 2, Feb. 2012, pp. 151–64. Pubmed, doi:10.2217/fon.11.152.
Murphy SK. Targeting the epigenome in ovarian cancer. Future Oncol. 2012 Feb;8(2):151–164.
Journal cover image

Published In

Future Oncol

DOI

EISSN

1744-8301

Publication Date

February 2012

Volume

8

Issue

2

Start / End Page

151 / 164

Location

England

Related Subject Headings

  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Molecular Targeted Therapy
  • Humans
  • Female
  • Epigenesis, Genetic
  • Antineoplastic Agents
  • Animals
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis