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Measurement of spontaneous signal fluctuations in fMRI: adult age differences in intrinsic functional connectivity.

Publication ,  Journal Article
Chen, N-K; Chou, Y-H; Song, AW; Madden, DJ
Published in: Brain Struct Funct
October 2009

Functional connectivity (FC) reflects the coherence of spontaneous, low-frequency fluctuations in functional magnetic resonance imaging (fMRI) data. We report a behavior-based connectivity analysis method, in which whole-brain data are used to identify behaviorally relevant, intrinsic FC networks. Nineteen younger adults (20-28 years) and 19 healthy, older adults (63-78 years) were assessed with fMRI and diffusion tensor imaging (DTI). Results indicated that FC involving a distributed network of brain regions, particularly the inferior frontal gyri, exhibited age-related change in the correlation with perceptual-motor speed (choice reaction time; RT). No relation between FC and RT was evident for younger adults, whereas older adults exhibited a significant age-related slowing of perceptual-motor speed, which was mediated by decreasing FC. Older adults' FC values were in turn associated positively with white matter integrity (from DTI) within the genu of the corpus callosum. The developed FC analysis illustrates the value of identifying connectivity by combining structural, functional, and behavioral data.

Duke Scholars

Published In

Brain Struct Funct

DOI

EISSN

1863-2661

Publication Date

October 2009

Volume

213

Issue

6

Start / End Page

571 / 585

Location

Germany

Related Subject Headings

  • Perception
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Image Processing, Computer-Assisted
  • Humans
  • Frontal Lobe
  • Female
  • Diffusion Tensor Imaging
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Chen, N.-K., Chou, Y.-H., Song, A. W., & Madden, D. J. (2009). Measurement of spontaneous signal fluctuations in fMRI: adult age differences in intrinsic functional connectivity. Brain Struct Funct, 213(6), 571–585. https://doi.org/10.1007/s00429-009-0218-4
Chen, Nan-kuei, Ying-hui Chou, Allen W. Song, and David J. Madden. “Measurement of spontaneous signal fluctuations in fMRI: adult age differences in intrinsic functional connectivity.Brain Struct Funct 213, no. 6 (October 2009): 571–85. https://doi.org/10.1007/s00429-009-0218-4.
Chen N-K, Chou Y-H, Song AW, Madden DJ. Measurement of spontaneous signal fluctuations in fMRI: adult age differences in intrinsic functional connectivity. Brain Struct Funct. 2009 Oct;213(6):571–85.
Chen, Nan-kuei, et al. “Measurement of spontaneous signal fluctuations in fMRI: adult age differences in intrinsic functional connectivity.Brain Struct Funct, vol. 213, no. 6, Oct. 2009, pp. 571–85. Pubmed, doi:10.1007/s00429-009-0218-4.
Chen N-K, Chou Y-H, Song AW, Madden DJ. Measurement of spontaneous signal fluctuations in fMRI: adult age differences in intrinsic functional connectivity. Brain Struct Funct. 2009 Oct;213(6):571–585.
Journal cover image

Published In

Brain Struct Funct

DOI

EISSN

1863-2661

Publication Date

October 2009

Volume

213

Issue

6

Start / End Page

571 / 585

Location

Germany

Related Subject Headings

  • Perception
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Image Processing, Computer-Assisted
  • Humans
  • Frontal Lobe
  • Female
  • Diffusion Tensor Imaging